Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 346 for “"Co-culture"”.
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Design of a single capillary-parenchymal co-culture bioreactor
Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2002.
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An evaluation of co-culture parameters effecting antibiotic production in soil microbes
… caused by antibiotic resistant bacteria, compounded by a reduction in antibiotic discovery and development, jeopardizes human health. Historically, antibiotics derive from secondary metabolites produced by soil microbes in pure culture, but recent genetic evidence suggests that microbes …
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Probiotic Modulation of Mucosal Immune Responses in an In Vitro Co-Culture Model
Probiotics confer health benefits through many mechanisms including modulation of the gut immune system. Gut mucosal macrophages play a pivotal role in driving mucosal immune responses. The local environment and macrophage subset determine immune response: tolerance, associated with an M2-like, …
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Dual-Chambered Membrane Bioreactor for the Dynamic Co-Culture of Dermal Stratified Tissues
… factors, such as burning agents, and is composed of the epidermis, dermis, and hypodermis layers. When burned, skin cannot regulate temperature or fluid transport, or stop bacterial infection. Due to the importance of the skin barrier, natural healing and grafting treatments aim to …
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Placental co-culture model reveals Listeria monocytogenes utilization of monocytes for vertical transmission
… barrier and infect the fetus, leading to congenital disabilities or death. Extracellular L. monocytogenes infection of the placenta has been well studied; however, the bacteria have not been observed translocating this barrier intracellularly. As an intracellular pathogen, L. monocytogenes …
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Investigating the movement of intestinal intraepithelial lymphocytes using an organoid co-culture system
… is the main site of nutrient absorption. It is continuously exposed to food antigens, and also several bacteria and microorganisms. Intestinal intraepithelial lymphocytes (IELs) are T cells that are interspersed between epithelial cells, above the basement membrane. This makes them one of the …
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Co-Culture of Amphibian Adrenal Cells: A Model of Medullary Control of Corticosteroidogenesis
Chromaffin-adrenocortical cellular interactions have become recognized as an important component of adrenocortical regulation, however, the mechanisms by which chromaffin cells modulate adrenocortical function are not well understood. To study chromaffin-adrenocortical cellular interactions …
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Experimental and Theoretical Study of Carbon Dynamics in an Algal-Bacterial Co-Culture
Microbial communities are an important component of biogeochemical cycles in ecosystems across our planet. Photosynthetic phytoplankton perform carbon fixation, converting carbon dioxide into organic molecules. Some of these organic molecules are released by the phytoplankton and can be …
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Cell Migration on Opposing Rigidity Protein Gradients: Single Cell and Co-culture Studies
Cell migration is a complex physiological process that is important from embryogenesis to senescence. In vivo, the migration of cells is guided by a complex combination of signals and cues. Directed migration is typically observed when one of these cues is presented to cells as a gradient. Several …
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The Effects Of Equine Spermatozoa/Oocyte Co-Culture On Spermatozoal Acrosome Reaction And Viability
The present study was conducted to determine the influence of oocyte and spermatozoal interactions on acrosome reaction and viability of equine spermatozoa during in vitro fertilization. Three ejaculates were collected from three stallions on an every other day basis. Semen was processed and …
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Co-culture of hepatocytes with mesenchymal stem cells for cellular therapy in liver disease
… showed that mesenchymal stem cells (MSCs) could maintain morphology and improve liver-specific metabolism of co-cultured hepatocytes. The present work aimed to optimise the MSCs co-culture system by testing adipose tissue (AT), bone marrow, and umbilical cord-derived MSCs at predefined …
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Systematic Co-Culture of IPSC-CM and IPSC-AN Promote Co-Maturation In Vitro
<p>The cardiac microenvironment is a complex system of multicellular interactions that enables proper heart function. In native heart muscle, sympathetic neurons (SN) and parasympathetic neurons (PSN) modulate the beat rate of cardiomyocytes (CM) to maintain homeostasis. Pluripotent stem cells can …
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Chondrocyte response to in vitro mechanical injury and co-culture with joint capsule tissue
… elucidated, several injury-related factors may contribute to the development of OA. These factors include but are not limited to altered mechanical loading and initiation of a cellular response in cartilage or other joint tissues at the time of the injury. Three in vitro models of joint injury …
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An <i>in vitro</i> human 3D co-culture model to study endothelial-astrocyte interactions
… of research is derived from <i>in vitro</i> eo-culture models in which astrocytes are cultured on a stiff, two-dimensional (2D) surface. Three-dimensional (3D) culture models closely mimic the in lJZVO cellular architecture and they bridge the gap between 2D culture models and animal models. …
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Endothelial cell and mural progenitor cell co-culture to promote angiogenesis in tissue engineered constructs
… The ability to vascularize a tissue engineered construct is one of the major hurdles for tissue engineering because it can take 2 weeks for an implanted construct to become vascularized. To produce prevascularized tissues, the cellular interactions that occur during vascular formation need to be …
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Lipid Production from a Louisiana Native Chlorella vulgaris/Leptolyngbya sp. Co-culture for Biofuel Applications
… to the high lipid productivity and minimum land competition with food crops. In this research, a Louisiana native Chlorella vulgaris/Leptolyngbya sp. co-culture was selected for lipid production. The goal of this work is to improve the lipid productivity and lipid composition of this co-culture …
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Enhanced biohydrogen production and substrate utilization by co-culture fermentation with reduced extracellular electron shuttles
… due to no greenhouse gas (GHG) emission during combustion and the highest conversion efficiency in fuel cells and highest energy content per unit mass compared to carbon-based energy carriers. However, three key challenges for large-scale biohydrogen production are to increase i) the hydrogen …
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Engineering complex liver models for drug screening and infectious diseases: a biomaterials and co-culture perspective
… modeling and drug screening. Micropatterned cocultures (MPCCs) of primary human hepatocytes (PHHs) and supportive stromal cells have been shown to display high hepatic functions for long-term drug and disease studies. However, MPCCs lack liver non-parenchymal cells (NPCs) and the proper …
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Sea-based Integrated Multi-Trophic Aquaculture: Investigation of a fish, bivalve and macroalgal co-culture system.
Sea-based integrated multi-trophic aquaculture (sIMTA) was explored as an amalgam of the processes of polyculture and biofiltration, with the primary objectives of improved aquaculture production efficiency and wastes remediation. The study established a coculture of Atlantic salmon (Salmo salar, …
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