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Showing 1 to 20 of 26 for “"Co-crystallisation"”.
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Novel Methods for Co-crystallisation
… research described in this dissertation mainly covers the development of novel technologies for co-crystallisation along with the discovering of plumbagin co-crystal and thermodynamic interrelationship between the co-crystal polymorphs. Co-crystallisation is a fast growing field in the area of …
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The co-crystallisation of sugars by the supersaturation process
Co-crystallising sugars by the supersaturation process was investigated using sucrose and lactose as the matrix sugars. The components to be cocrystallised with either sucrose or lactose were a variety of mono- and disaccharides along with sweeteners such as saccharin.Analysis of the materials …
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Co-crystallisation of α,ω-dicarboxylic acids with nicotinamide and isonicotinamide
Pharmaceutical co-crystallisation is an alternative and potentially reliable method to manipulate physical properties of API’s via supramolecular synthesis. A number of binary co-crystals were synthesised using different solvents, different stoichiometric ratios (ratio of starting materials) and …
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Investigating co-crystallisation of primary amides and carboxylic acids. Comparative analysis of Benzamide, Isonicotinamide and Nicotinamide co-crystal growth with carboxylic acid.
… is the design of crystalline material using non-covalent synthesis. Co-crystals are multi-component crystals which are constructed from complementary intermolecular interactions, they are also known as supramolecular complexes. Design of such materials utilises the synthon approach, this involves …
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Ultrasound Assisted Processing of Solid State Pharmaceuticals. The application of ultrasonic energy in novel solid state pharmaceutical applications, including solvent free co-crystallisation (SFCC) and enhanced compressibility
… of this study was to develop a new method for co-crystal preparation which adhered to green chemistry principles, and provided advantages over conventional methods. A novel, solvent-free, high-power ultrasound (US) technique, for preparing co-crystals from binary systems, was chosen as the …
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Phase behaviour and crystal nucleation in complex multicomponent system
The continuing research and use of co-crystallisation for separation, purification and modification of pharmaceutical materials in multiple industrial sectors can be attributed to the potential for high control of product quality attributes. Nucleation is a key phenomenon in crystallisation that …
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Applications of ultrasound in pharmaceutical processing and analytics.
… of high power ultrasound in the slurry crystallisation and application of low power ultrasound (3.5 MHz) as process analytical technology (PAT) tool to understand pharmaceutical processing such as hot melt extrusion. The effect of high power ultrasound (20 kHz) on slurry …
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Preparation and applications in confectionery of co-crystalline sugar products and a novel hydrated form of sucrose
… an important role in many food products. The conventional crystallisation of sucrose gives solid, dense cubic crystals that have a limited surface area. On the other hand, co-crystallisation of sucrose is a process where a second ingredient is added to a supersaturated sucrose solution before …
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Polymer and metallodielectric based photonic crystals
The bottom-up colloidal synthesis of photonic crystals has attracted interest over top-down approaches due to their relatively simplicity, the potential to produce large areas, and the low-costs with this approach in fabricating complex 3-dimensional structures. This thesis focuses on the bottom-up …
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Cyclodextrin-based rotaxanes for material science applications
… blocking groups were prepared to complete the set of rotaxanes 1.9, 1.10, 1.17 and 1.18 with 2,6-dimethylaniline and 3,5-dimethylaniline blocking groups, with azobenzene- and stilbene-based axles. Chapter 3 describes the solid-state structures/packing, morphology and crystal growth …
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Cyclodextrin-based rotaxanes for material science applications
… blocking groups were prepared to complete the set of rotaxanes 1.9, 1.10, 1.17 and 1.18 with 2,6-dimethylaniline and 3,5-dimethylaniline blocking groups, with azobenzene- and stilbene-based axles. Chapter 3 describes the solid-state structures/packing, morphology and crystal growth …
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Separation of enantiomers of Baclofen
… were individually used as substrates in co-crystallisation experiments with several resolving agents. Experiments were conducted in the solid state and in solution. The (-) enantiomer of the lactam and the ( +) enantiomer of the glutaramide were found to cocrystallise selectively with …
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Supramolecular derivatives of selected bioactive compounds : a physicochemical study
… to prepare new solid phases of three bioactive compounds: the steroidal anticancer agent 2-methoxyestradiol [polymorphs and cyclodextrin (CD) inclusion complexes], its derivative 2-methoxyestradiol-bis-sulfamate (polymorphs), and the antiretroviral agent, nevirapine (co-crystals). The solubility …
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The Formation of Pharmaceutical Co-crystals by Spray Drying. An Investigation into the Chemical and Physical Factors Affecting the Production of Pharmaceutical Co-crystals by Fast Evaporation and Spray Drying
… dryer was performed for scale-up and rapid, continuous crystallisation of co-crystals from solution. The study emphasise on developing co-crystals of two structurally similar compounds, caffeine (CAF) and theophylline (THEO) with various di-carboxylic acids. The incongruently soluble pair of …
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Molecular interactions in pharmaceutical preformulation and supramolecular complexes. Structural properties governing drug-plasma protein binding and investigation of amino acids co-crystals
… preformulation includes the evaluation of pharmacokinetic, pharmacodynamic and physicochemical properties of the drug molecules that aid the formulation. However, it has a limited role in determining drug dosage optimisation in the formulation. The study of drug-Plasma Protein Binding (PPB), and …
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A structural database for pharmaceutical salt selection
… development to modulate and optimise the physicochemical properties of a drug molecule containing an ionisable functional group. The current approach to salt selection relies on semi-empirical screening of the pharmaceutical molecule in combination with different counterions for the formation …
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Identifying potential binding sites of Nectin 4 for bespoke anti-cancer peptides
… to be over expressed in some of the deadliest/common cancer types of the bladder, pancreas, lung and breast. Nectin 4 has also been reported to play a role in metastasis. Consequently, lending itself to be an attractive drug target for anti-cancer treatment. Bicycle therapeutics has taken …
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Bacterial acid phosphatase and its application to waste remediation and metal recovery
… phosphate (HUP) on Serratia sp. removed \(^{60}\)Co, \(^{137}\)Cs and \(^{90}\)Sr via intercalative ion exchange into the HUP crystal lattice. Due to their non toxic and non radioactive nature, zirconium phosphates offer an alternative to HUP for the decontamination of potable water. Zirconium was …
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Directing the Assembly of Multicomponent Organic Crystals. Synthesis, characterisation and structural analysis of multicomponent organic systems formed from dynamic processes.
Directed assembly of molecular solids continues to attract widespread interest with its fundamental application in a wide range of commercial settings where control of the crystalline state of materials corresponds with product performance. These arenas include pharmaceuticals, personal care …
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Design and Synthesis of Inhibitors of Mycobacterium tuberculosis Menaquinone D (Mtb MenD) as Potential Therapeutics for Tuberculosis (Tb)
… central to mitochondrial energy metabolism in Mycobacterium tuberculosis (Mtb) and other Gram-positive pathogenic bacteria. Menaquinone biosynthesis presents a potential target for therapeutic intervention, as it is not produced in humans. In this work, libraries of novel inhibitor candidates …
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