Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 52 for “"Co-crystal"”.
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Co-crystal screening of poorly water-soluble active pharmaceutical ingredients. Application of hot stage microscopy on curcumin-nicotinamide system and construction of ternary phase diagram of fenbufen-nicotinamide-water co-crystal system.
… longa and has been reported to possess pharmacological activities. Unfortunately this compound suffers from poor bioavailability and rapid neutral-alkaline degradation. Co-crystal of curcumin is one option under exploration, motivated by the fact that a number of active pharmaceutical …
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Efavirenz pre-formulation study : selection of a cyclodextrin inclusion complex or co-crystal complex for tabletting
… This study aims to choose a pre-formulation protocol with the best efavirenz derivative in literature between co-crystals and CD inclusion complexes. Upon selection of the efavirenz derivative, the complications of both small scale and large scale laboratory pre-formulation production is …
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Mechanistic Understanding of Co-crystal solubility and dissolution by using a combination of Experimental and Molecular Modelling Techniques
… level of Flufenamic acid and Carbamazepine co-crystals in the presence of polymers. This study has been separated into four sections: (1) Formation of pharmaceutical co-crystals: Three pharmaceutical co-crystals of poorly water soluble active pharmaceutical ingredient (API) of Flufenamic …
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Investigating co-crystallisation of primary amides and carboxylic acids. Comparative analysis of Benzamide, Isonicotinamide and Nicotinamide co-crystal growth with carboxylic acid.
Crystal Engineering is the design of crystalline material using non-covalent synthesis. Co-crystals are multi-component crystals which are constructed from complementary intermolecular interactions, they are also known as supramolecular complexes. Design of such materials utilises the synthon …
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Impact of mixed solvent on co-crystal solubility, ternary diagrams and crystallisation scale-up. Crystallisations of Isonicotinamide ¿Benzoic Acid Co-crystals from Ethanol ¿Water Co-solvent System.
The production of stable solid crystalline material is an important issue in the pharmaceutical industry and the challenge to control the desired active pharmaceutical ingredient (API) with the specific chemical and physical properties has led to more development in the drug industry. Increasing …
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Novel Methods for Co-crystallisation
… research described in this dissertation mainly covers the development of novel technologies for co-crystallisation along with the discovering of plumbagin co-crystal and thermodynamic interrelationship between the co-crystal polymorphs. Co-crystallisation is a fast growing field in the area of …
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Phase behaviour and crystal nucleation in complex multicomponent system
The continuing research and use of co-crystallisation for separation, purification and modification of pharmaceutical materials in multiple industrial sectors can be attributed to the potential for high control of product quality attributes. Nucleation is a key phenomenon in crystallisation that …
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Investigation of a solvent-free continuous process to produce pharmaceutical co-crystals. Understanding and developing solvent-free continuous cocrystallisation (SFCC) through study of co-crystal formation under the application of heat, model shear and twin screw extrusion, including development of a near infrared spectroscopy partial least squares quantification method
This project utilised a novel solvent-free continuous cocrystallisation (SFCC) method to manufacture pharmaceutical co-crystals. The objectives were to optimize the process towards achieving high co-crystal yields and to understand the behaviour of co-crystals under different conditions. Particular …
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Ultrasound Assisted Processing of Solid State Pharmaceuticals. The application of ultrasonic energy in novel solid state pharmaceutical applications, including solvent free co-crystallisation (SFCC) and enhanced compressibility
… of this study was to develop a new method for co-crystal preparation which adhered to green chemistry principles, and provided advantages over conventional methods. A novel, solvent-free, high-power ultrasound (US) technique, for preparing co-crystals from binary systems, was chosen as the …
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The Formation of Pharmaceutical Co-crystals by Spray Drying. An Investigation into the Chemical and Physical Factors Affecting the Production of Pharmaceutical Co-crystals by Fast Evaporation and Spray Drying
Crystal engineering study using spray dryer was performed for scale-up and rapid, continuous crystallisation of co-crystals from solution. The study emphasise on developing co-crystals of two structurally similar compounds, caffeine (CAF) and theophylline (THEO) with various di-carboxylic acids. …
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Directing the Assembly of Multicomponent Organic Crystals. Synthesis, characterisation and structural analysis of multicomponent organic systems formed from dynamic processes.
Directed assembly of molecular solids continues to attract widespread interest with its fundamental application in a wide range of commercial settings where control of the crystalline state of materials corresponds with product performance. These arenas include pharmaceuticals, personal care …
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Crystal engineering approaches to solid-state pharmaceutical systems
Control of a solid drug's physical form is an important stage of drug development, in order to best optimise the physicochemical properties of the drug. It is also important for intellectual property and regulatory considerations. Commonly, optimisation of a solid drug form moves beyond controlling …
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Structural investigations with high pressure techniques and multicomponent systems
This thesis illustrates the use of high pressure crystallography techniques for the discovery and investigation of solid-state forms and probes the relationship between molecular structure and compression of both single and multicomponent systems. As well as investigating a data-driven approach to …
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The association of the secondary DNA-binding site of linker histone H5 in a nucleosome
… site of GH5 was modelled by homology to the co-crystal structure of the E. coli CAP-DNA complex.
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Co-processing of drugs and co-crystal formers and its effect on pharmaceutical dosage-form performance. Co-crystallization of urea/ 2-methoxybenzamide, caffeine/ malonic acid, caffeine/ oxalic acid and theophylline/ malonic acid systems: Solid-state characterization including imaging, thermal, X-ray and Raman spectroscopic techniques with subsequent evaluation of tableting behaviour
… on the solid-state characterization of different co-crystal system as well as the effect of co-crystallization of these systems on pharmaceutical dosage form performance. Urea/ 2-MB, caffeine/ malonic acid, caffeine/ oxalic acid and theophylline/ malonic acid co-crystals were prepared using …
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Design, synthesis, and biological evaluation of Antimycobacterial agents from plant derived Betulinic acid, Oleanolic acid and their derivatives
… treatment of the disease are not effective for complete cure and in most cases, usually come with side effects, as a result of which new set of potent drugs are needed. In a quest to develop potent hit/drug leads for TB, betulinic acid (BA) and oleanolic acid (OA) were isolated respectively from …
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Detection and characterisation of secondary relaxations in solids using thermally stimulated current spectroscopy
Thermally stimulated current (TSC) spectroscopy has been used, in these reported investigations, as an innovative experimental technique for the detection and characterisation of secondary relaxation phenomena in the crystalline state for a number of low-molecular weight organic materials (LOMs), …
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Preparation, characterisation and structural analysis of salts and co-crystals of organic compounds
… factors influencing the formation of a binary compound and the proton transfer within the binary compound have been investigated. The formation of a binary compound, or heteromeric system, over a homomeric system requires the heteromeric system to be more energetically favourable than the …
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Investigations in molecular structure: from scattering to molecular complexes of brominated compounds
… to attempt to monitor the nucleation process in crystallisation, and to investigate structural outcomes of crystallisation processes, with reference to polymorphism and intermolecular interactions. To achieve this, work on the investigation of nucleation and early-stage crystallisation was …
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