Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 66 for “"Co-activator"”.
-
Mechanistic Control of The Coldinduced Augmentation of The Transcriptional Co-Activator PGC-1α
Cold water immersion is commonly used to alleviate the stress and damage that ensues following strenuous exercise. Alongside its purported performance and analgesic benefits recent literature highlights the positive impact it may have towards endurance adaptive responses, particularly on key …
-
The IRAK-1 binding protein SIMPL functions as a p65/RELA co-activator in NF-KB dependent gene expression following tumor necrosis factor-alpha stimulation
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
-
Part I: Steroid Receptor CO-Activator 3 (SRC-3) Expression in Lung Cancer and its Role in Regulating Cancer Cell Survival and Proliferation; Part II: Development of Phosphospecific Peptoid Ligand
PART I: STEROID RECEPTOR CO-ACTIVATOR 3 (SRC-3) EXPRESSION IN LUNG CANCER AND ITS ROLE IN REGULATING CANCER CELL SURVIVAL AND PROLIFERATION Steroid receptor coactivator-3 (SRC-3) is a histone acetyltransferase and nuclear hormone receptor (NHR) coactivator, located on 20q12, which is amplified in …
-
Identifying the Molecular Mechanism of TAZ-Induced Lung Tumorigenesis
The transcriptional co-activator with PDZ-binding domain (TAZ) is a transcriptional co-activator and downstream component of the tumor suppressor Hippo pathway that plays critical roles in organ size control, stem cell self-renewal, tumorigenesis and drug resistance. Recently, TAZ has been …
-
Gain-of-Function Mouse Models to Investigate Biological Roles of Prmt6
… H3R2 (arginine 2 of histone H3) residue, which counteracts the activating H3K4me3 mark. PRMT6 has been shown to behave both as transcriptional co-repressor (i.e. trhrombospondin-1, p21, p53), and co-activator (nuclear receptors). The co-repressor function of PRMT6 is likely the result of H3K4me3 …
-
The Interplay Between PGC-1 and Autophagy During Metabolic Alterations in Skeletal Muscle
PGC-1α is a transcriptional co-activator well established as a potent regulator of oxidative metabolism in skeletal muscle. This co-activator mediates metabolic adaptation to exercise by orchestrating mitochondrial biogenesis. PGC-1α is also integral for the maintenance of muscle mass and function …
-
Structural Studies of Three Factors That Affect the Prokaryotic Transcription Cycle; Microcin J25, LAMBDA Q and T4 GP33
… genes; and Gp33, a T4 phage protein that is a co-activator of T4 phage late gene transcription. We determined that the Microcin J25 peptide (MccJ25) has a lassoed-tail structure using mass spectrometry and NMR. The 21 amino acid MccJ25 peptide is produced from a 58 amino acid pro-peptide, McjA, …
-
Investigating transcription factor dynamics and chromatin environment during Notch response
… a multitude of cell signalling pathways control patterning, cell fate determination and tissue assembly. Notch signalling is one such, highly conserved, pathway in multicellular animals that regulates a large diversity of developmental processes. Its function is crucial for normal …
-
The Regulation and Function of Drosophila Acinus
Autophagy and growth control are two processes critical to organisms that mutually antagonize and regulate on each other. Several well known connections between these processes have been described, but here I describe a new link. Using Drosophila melanogaster as a model system, my thesis research …
-
Regulation of DNA (Cytosine-5) Methyltransferase 1 in the cell cycle and its role(s) in doxorubicin-mediated micronuclei formation
The expression of DNMT1 is critical in coordinating DNMT1 activity with biological processes and therefore must be tightly regulated in the cell cycle. Several studies have shown that DNMT1 expression level is inversely correlated with p21WAF1 protein, but the exact mechanism remained unresolved. …
-
Identifying Novel Interaction Between CDK8 Kinase Module and The Deubiquitinating Enzyme Ubiquitin Specific Protease 7 (USP7)
… thesis explores the role of USP7 in regulating components of gene expression regulators. The gene expression of target genes is fine-tuned by the transcriptional co-activator, the Mediator complex. Our group has determined that Cyclin Dependent Kinase 8 (CDK8) and Mediator Complex Subunit 12 …
-
Functional In Vivo Screen Identifies Pygo2 As A Putative Gene to Promote Prostate Cancer
<p>Poor prognosis of prostate cancer is correlated with rampant chromosomal copy number alterations, highlighting the potential function of genes with copy number gains and losses in driving prostate cancer progression. To identify putative genes promoting prostate cancer, an <em>in vivo</em> …
-
Trim24-Regulated Estrogen Response Is Dependent On Specific Histone Modifications In Breast Cancer Cells
<p>In this dissertation, I discovered that function of TRIM24 as a co-activator</p> <p>of ERα-mediated transcriptional activation is dependent on specific histone</p> <p>modifications in tumorigenic human breast cancer-derived MCF7 cells. In the first</p> <p>part, I proved that TRIM24-PHD finger …
-
Phosphorylation of Glucocorticoid Receptor tau1c Transactivation Domain Enhances Binding to CREB Binding Protein (CBP) TAZ2 and a Microfluidic, High Throughput Protein Crystal Growth Method for Microgravity
The glucocorticoid receptor (GR) N-terminal domain (NTD) contains a transactivation domain (activation function 1; AF-1). Although GR AF-1 is phosphorylated, effects of GR phosphorylation upon AF-1 activity and cofactor recruitment are not clear. Most GR AF-1 activity is confined to an unstructured …
-
Molecular mechanism of action of the glucocorticoid receptor:Role of ligand-dependent receptor phosphorylation and half-life in determination of ligand-specific transcriptional activity. : Contents Pages
Glucocorticoids mediate their effects by binding to the glucocorticoid receptor (GR), resulting in modulation of transcription of target genes via direct binding to DNA or tethering via proteinprotein interactions. A central question is what determines the rank order of ligand-selective …
-
AML1/ETO Downregulates the Transcription Factor PU.1 in Acute Myeloid Leukemia
AML1-ETO is a fusion protein encoded by the translocation t(8;21) and found in 15% of acute myeloid leukemia patients. Here, we report a negative functional impact of AML1-ETO on the transcriptional activity of PU.1, an important transcription factor for normal myeloid differentiation. We have …
-
C/EBPalpha downregualtes c-jun expression
… crucial for the differentiation of granulocytes. Conditional expression of C/EBPa triggers neutrophilic differentiation and C/EBPa can block TPA induced monocytic differentiation of bipotential myeloid cells. In C/EBPa knockout mice, no mature granulocytes are present. A dramatic increase of c-jun …
-
A Cell-Based Model to Study Factors that Drive Diffuse Astrocytoma Development
Secondary gliomas are an incurable form of brain cancer that are diagnosed in people at a median age of 45 years. Next-generation sequencing has found that secondary glioblastomas have a distinct genetic profile from the more common primary glioblastomas, which are diagnosed in people typically …
-
Molecular Consequences of High Taz Expression In Gliomas
<p>Diffuse high grade gliomas are complex and lethal neoplasms of the adult central nervous system that are driven by a range of genetic and epigenetic alterations. Molecular classification of these tumors has identified different transcriptional subtypes, the most notable being Proneural (PN) and …
-
Modulation of GR transcriptional signalling by HIV-1 Vpr insights into regulation by progestins
It has been 30 years since HIV was first discovered, yet the molecular mechanisms whereby the virus mediates its pathogenic effects have not yet been completely elucidated. The glucocorticoid receptor (GR) is a ligand-activated host transcription factor, which mediates anti-inflammatory effects in …
Page 1 of 4