Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 22 for “"Clusterin"”.
-
Structure and activity of human clusterin.
Clusterin is a heterodimeric disulfide linked glycoprotein secreted by many epithelia in adult and developing tissues. Clusterin is also induced in response to diverse injury or cell death stimuli. The protein interacts with, and is suggested to have, a relatively non specific affinity for markedly …
-
Clusterin: A Regulator of Glial Biology and Alzheimer’s Disease Pathogenesis
… play significant roles in AD pathogenesis. Clusterin (CLU), also known as apolipoprotein J, is the third most prominent risk gene associated with late-onset AD (LOAD). The precise role of CLU in the brain and in LOAD pathogenesis remains unclear. Multiple pieces of evidence have pointed to …
-
DNA methylation of the clusterin promoter: Associations with Alzheimer’s Disease risk and related phenotypes
… risk. The third most associated AD risk gene is Clusterin (CLU), is also involved in the cholesterol/lipid pathway. CLU has been implicated in both a protective and aggravating role in AD making it a compelling gene for further study. The identification of a fluid-based AD biomarker/s has become …
-
Regulation of the Insulin-like Growth Factor 1-Secretory Clusterin Expression Axis in Genomic Instability and Cell Stress
Secretory clusterin (sCLU) is a pro-survival factor that is up-regulated in human tumors and after exposure to cell stress. Understanding the regulation of sCLU expression in cancer, and after exposure to therapeutic agents, could reveal new therapeutic targets for cancer treatment. A DNA damage …
-
An investigation into the regulation and expression of the tumour suppressor gene clusterin in oral, cervical and nasopharyngeal cancer
Clusterin (CLU) is a multifunctional glycoprotein widely expressed as two isoforms. One isoform, sCLU is secreted, cytoplasmic and anti-apoptotic, the other, nCLU, is nuclear and pro-apoptotic. Seven genes, DKK3, TIMP1, CADM1, AKAP12, KLF4, RNASET2 and CLU were identified to be candidate tumour …
-
Plxna4 and its role in neuronal survival in the developing zebrafish hindbrain
… indicates that the secreted heat shock protein Clusterin is a candidate ligand to mediate apoptosis through Plexina4, as Clusterin is known to promote cell survival, and bind Plxna4. I find that clu is expressed by the floorplate of the embryonic zebrafish hindbrain. Epistasis experiments reveal …
-
A Missing link between lipid metabolism, inflammation and apoptosis: Phospholipase A2-activating protein (PLAA)
… expression of annexin A4 (a PLA2 inhibitor) and clusterin. We demonstrated that extracellular clusterin limited the production of PGE2. We showed that upon TNF-¦Á stimulation, plaa high cells revealed enhanced PLA2 activation, COX-2 expression and PGE2 production. Furthermore, we found that in …
-
Estrogen Receptor-Mediated Gene Expression in Cultured Epithelial Cells of Rat Efferent Ductules
… of endocytosis and the expression of clusterin and estrogen receptor mRNAs. Thus, this in vitro system was suitable for the investigation of estrogen regulations in the efferent ductules and initial segment epididymidis. Differential display PCR analysis demonstrated that …
-
Characterising the early aggregation events of human lysozyme using single-molecule microscopy
… HuL oligomers and the extracellular chaperone clusterin were investigated. Previous studies have shown that clusterin inhibits I59T HuL aggregation by interacting with species formed early in the aggregation pathway. Here, we show that clusterin enhances the population of small high-FRET …
-
Molecular interactions and their impact on life sciences
… of small heat shock proteins, such as clusterin, αB-crystallin and the Brichos chaperone domain, to aggregated forms of amyloid-beta and α-synuclein, protein aggregates that are associated with a wide range of neurodegenerative diseases. The three chaperones are crucial components of …
-
Evidenze molecolari del ruolo antiproliferativo e pro-apoptotico della clusterina in cellule epiteliali prostatiche umane
The Clusterin (CLU) gene produces different forms of protein products which vary in their biological properties and distribution within the cell. Both the extra- and intracellular CLU forms regulate cell proliferation and apoptosis. Dis-regulation of CLU expression occurs in many cancer types, …
-
Molecular regulation of neuronal apoptosis in PC12 cells.
… apoptosis. Within 8 hours of VM26 exposure, clusterin (TRPM-2) and IGFBP2 (Insulin-like growth factor binding protein 2) were both upregulated by 3 and 4 fold respectively. Cathepsin B (RSG-2) and RSG-3 (embigin) exhibited marginal changes in expression, only about 1.2 fold, over the 24 hour …
-
The Role of Glucocorticoid Signaling in Prostate Cancer Health Disparities
… Growth Factor p75 (LEDGF/p75) and Clusterin (CLU). Results revealed a robust pattern of GR-induced upregulation of LEDGF/p75 and CLU in African-American (AA) PCa cells compared to European-American (EA) PCa cells. We also detected increased GR transcript expression in AA PCa …
-
Blood and Lumbar Fluid Biomarker Changes in Patients with HIV-Associated Neurocognitive Impairment Treated with Lithium: Analysis from a Randomised Placebo-Controlled Trial
… α1-antitrypsin, PEDF, CC4, ICAM-1, RANTES, clusterin, and cystatin c. We recruited 61 participants (placebo = 31; lithium = 30). The age baseline mean was 40 (±8.35) years and the median CD4+ T-cell count was 498 (IQR: 389 – 651) cells/μL. Biomarker concentrations between groups did not …
-
Proteomic Characterization of Eggshell Membranes and Their Effect on Poultry Physiology and Immunity
… them are lysozyme, ovotransferrin, ovocleidin, clusterin, ovokeratin ovodefensin and many more. These proteins are not only antimicrobial in nature, but also many, play a vital role in metabolic and developmental processes. A series of experimental trails were done in which chickens by feeding …
-
Microfluidics and chemical kinetics to analyse protein interactions, aggregation, and physicochemical properties
… nucleation stages. These include the chaperones clusterin and brichos, as well as soot and pure carbon nanoparticles. Importantly, the addition of both chaperones to Aβ(1-42) solutions has an additive inhibitory effect on aggregation. My findings will improve the characterization of the …
-
The Role of Exogenous Somatotropin, Ovariectomy and Extracellular Matrix in Bovine Mammary Gland Development
… Col while IGF-BP6 was increased on LM with BI. Clusterin, a ubiquitous non-adhesive ECM protein was not affected by ECM substrate but did increase over time. In conclusion, we propose that the mammary gland is not able to respond to GH at this age and that while OVX did effect the expression of …
-
Investigating the effects of extracellular biomolecules on Aß1-42 oligomer uptake and trafficking by microglia cells
… extracellular biomolecules, namely the chaperone clusterin (Clu) and the antimicrobial enzyme lysozyme, an important component of the innate immune system. Microglia cells are the primary immune cells of the brain and as such, considered to be the first line of defense against intruders. In more …
-
The Development and Implementation of a TMT-SRM Assay for the Validation of Candidate Biomarkers of Alzheimer’s Disease
… disease.<br/>The panel of proteins included clusterin, complement C3, alpha-2- macroglobulin, gelsolin, fibrinogen gamma-chain, serum amyloid p-component and complement factor H. These proteins were previously found to be differentially expressed between plasma of Alzheimer’s disease subjects …
-
Immortalisation, characterisation and differentiation of temperature sensitive cell lines from the Olfactory Neuroepithelium
… induced OP55 cells also expressed mRNA for clusterin - a molecule that has no homology with olfactory receptor transcripts but is involved in differentiation during embryogenesis.
Page 1 of 2