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Showing 1 to 2 of 2 for “"Clustered DNA damage"”.

  1. Shedding Light on the Biological Effects of Ionising Radiation on DNA Using Advanced Optical Microscopy

    D’Abrantes, SofiaOxford Brookes University2020

    … (IR) stem from its unique ability to produce clustered DNA damage (CDD) and double-strand breaks (DSBs). CDD consists of two or more lesions in close proximity, including DSBs, single-strand breaks and/or base damages. CDD complexity increases with rising linear energy transfer (LET) of …

    oxford-brookes Repository record

  2. Understanding The Repair Mechanisms at Ionizing Radiation-induced Damage in The Human Genome

    Dutta, ArijitThe University of Texas Medical Branch at Galveston2019

    Ionizing radiation (IR) such as X-rays induce damage clusters in the genome that include DNA double-strand breaks (DSB) with unligatable dirty ends, along with more frequent oxidized bases and single-strand breaks (SSB). While nonhomologous end joining and homologous recombination are major DSB …

    utmb Repository record