Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Clr3"”.
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Using S. pombe to Study the Biological Roles of the Histone Deacetylases Sir2 and Clr3 and the DEAD-Box RNA Helicase Ded1
… of the histone deacetylases (HDACs) Sir2 and Clr3 in heterochromatin formation and cancer associated mutations of the DEAD-box RNA helicase DDX3X, homolog of fission yeast Ded1, in translational control. Heterochromatin in fission yeast is characterized by hypoacetylation as well as …
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The Mi-2 Homolog Mit1 Actively Positions Nucleosomes Within Heterochromatin to Suppress Transcription
… contributes to SHREC function independently of Clr3’s histone deacetylase activity on Lys14 of histone H3. We propose that chromatin remodeling by Mit1 cooperates with the Clr3 and other chromatin modifiers to stabilize heterochromatin structure and to prevent access to the transcriptional …
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Molecular and Genetic Analysis of Novel Epigenetic Silencing Factors Dhp1, Lsd1, and Lsd2
… and mutants of histone deacetylases Clr3 and Sir2. We also generate novel lsd1 and lsd2 mutants for these analyses, which reveal a role for these enzymes in epigenetic silencing. In the fourth chapter, we use the novel lsd1 and lsd2 mutant strains to further investigate the role of …
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A multi-proxy approach to investigating the latest Holocene (~4,500 yrs. BP) vegetational history of Catahoula Lake, Louisiana
… input into the lake. Sediment cores, CLR1 and CLR3, were radiocarbon dated and provide pollen and phytolith evidence for dynamic changes in lacustrine hydrology and vegetation during the last ~4,500 years B.P. The transition out of the Hypsithermal period (~4,500 to 3,700 yrs B.P.) is …