Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"Clr-b"”.
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Transcriptional Regulation of Clr-b (Clec2d) in Health and Disease
… NKR-P1B inhibitory receptor. The NKR-P1B-ligand, Clr-b, is broadly expressed by normal healthy cells, yet rapidly downregulated during pathological alterations, resulting in NK cell disinhibition via NKR-P1B. This thesis investigates transcriptional regulation of Clr-b during health and disease. A …
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Modulation of Clr-b Ligand for the Inhibitory NKR-P1B NK Cell Receptor in Response to Transformation and Genotoxic Stress
… recognition of MHC-I. The ligand pair NKR-P1B:Clr-b participates in “missing-self” recognition of tumour and infected cells, but the role of this axis in sensing stressed cells remains unknown. This thesis focuses on the modulation of Clr-b by genotoxic stress and transformation In the first …
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Genetic Investigation of MHC-independent Missing-self Recognition by NK Cells
… recognition, and more specifically, the NKR-P1B:Clr-b receptor-ligand system and its role in bone marrow transplantation. In the first results chapter, we generated hybridoma clones producing monoclonal antibodies against another inhibitory receptor in the Nkrp1 receptor family, NKR-P1G via the …