Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Clotting Factors"”.
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Engineering rFVIIa-loaded platelets; a novel approach to treating acute bleeding
… as well as platelet transfusion and recombinant clotting factors such as rFVIIa. However, the use of recombinant clotting factors is limited due to cost and adverse side effects resulting from increased thrombosis, such as increased rate of myocardial infarction and cerebrovascular accidents. …
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Self-Assembling Peptide Nanofibers RADA16 and IEIK13 for Rapid Hemostasis
… examining the effects on the activity of several clotting factors as well as effects on clot formation. While some effects on the activity of individual clotting factors were observed, in vitro testing using whole blood showed no significant differences in clot formation. Finally, we developed …
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The Chelating Effect of 5-(p-Acetoxy-Phenyl)-4,6 Dicarbethoxy Cyclohexanedione-1,3 on the Calcium Concentration of Human Blood Serum: Also the Anticoagulant Effect of the Above Compound
… so how much? Serum has been selected because the clotting factors have been removed. |2. Whether or not 5-(p-acetoxy~phenyl)-4,6 dicarbeth-oxycyclohexanedione-1,3 prevents whole blood (dog blood) from coagulating. If so for how long? And in what concentration? |3. To determine whether or not the …
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Disabled-2 regulates platelet heterotypic and homotypic aggregation through sulfatide binding
… one another. Platelet granules contain important clotting factors and regulators of aggregation. Disabled-2 (Dab2) is a negative regulator of platelet aggregation released from platelet α-granules. Dab2 binds to the αIIbβ3 integrin, through the PTB domain, and blocks fibrin binding to the integrin …
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Discovery Of Inactive E* Conformations In Thrombin And Other Vitamin K- Dependent Clotting Proteases
… proteases belonging to Vitamin K-dependent clotting factors is significantly affected by Na+ through an allosteric mechanism. Over the past 30 years, structural and biochemical studies revealed that Na+ enhances the enzymatic properties of these proteases from a low activity, E, to a high …
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Bloodmeal determinants of Zika virus infection of Aedes (Stegomyia) aegypti mosquitoes
The following dissertation aims to ascertain how factors in the blood of viremic mammals influence the infection of Aedes (Stegomyia) spp. mosquitoes with the arboviruses Zika (ZIKV). It has been repeatedly observed in both flaviviruses and alphaviruses that bloodmeals taken from viremic animals …
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An investigation into the understanding of basic genetic inheritance amongst amaXhosa caregivers of patients with Haemophilia
… that are caused by deficiencies in blood clotting factors. The condition predominantly affects males, while females are carriers and usually unaffected. These bleeding disorders have a profound impact on the daily life of the affected individual, on carrier mothers and close family. …
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Exploring Anti-FVIII Antibodies in Haemophilia A - Role in In Vitro Haemostasis and Clinical Disease
… to by-passing agents (Paper I). Moreover, FVIII clotting factors were found to potentiate the in vitro effect of by-passing agents on thrombin formation in plasma from patients with HA exhibiting inhibitors, indicating that further assessment of this treatment strategy in a clinical context is …
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The Requirement for Viable Platelets in the Coagulation of Heparinized Blood
… platelet factor 3 (PF3) is sufficient to promote clotting of unheparinized blood, viable platelets, in addition, are required for clotting of heparinized blood. A possible hypothesis which explains these findings is as follows:</p> <p>In the unheparinized situation, coagulation factors are …
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Recombinant Engineering Strategies for the Production of Therapeutic Coagulation Factor Proteins
… complex human proteins, especially coagulation factors, are highly homologous and consistently employ non-human mammalian cell lines and plasmid-based gene transfer techniques to engineer transgenic cell lines. This resource-intensive strategy must be carried out for each new protein of …
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Contribution of different types of phospholipids in blood coagulation
… become activated and proper interaction of blood clotting proteins with membranes of activated platelets is essential for maintaining a balanced hemostasis. Hemophilia and thrombosis are the two extremes of an imbalanced hemostasis where patients with hemophilia suffer from severe bleeding and …
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Towards atomistic characterization of blood coagulation proteins by NMR spectroscopy
… biomedical importance, and most essential blood-clotting reactions occur preferentially on phospholipid membranes. Understanding the interactions between the proteins and membranes involved in blood clotting is crucial to the continued development of successful treatments for blood coagulation …