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Showing 1 to 20 of 113 for “"Clot"”.
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Clot retraction
… general understanding of the mechanism of blood clotting, every aspect of this mechanism has become of practical clinical importance, and no serious effort to clarify the question can be considered wasted. It is peculiar that the last phase of coagulation, the contraction of the clot, which is by …
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In-vitro Clot Formation and Failure
… after traumatic injury is failure of hemostatic clot formation at wound sites. After trauma, approximately 25-30% of severe injured patients display trauma induced coagulopathy (TIC) which is a multifactorial condition that causes poor clot formation and performance. A decreased level of …
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Computational Studies on the Mechanical Properties of Muscle and Blood Clot Elasticity
… for muscle from the protein titin and for blood clots from the protein fibrinogen. These investigations utilize free dynamics MD to verify experimentally observed conformations of proteins, SMD to probe their response to mechanical forces, and adaptive biasing force (ABF) simulations to measure …
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A platelet-mediated paradigm for the targeted delivery of microencapsulated, clot-augmenting biotherapeutics
… to sense and actuate targeted delivery of a clot-augmenting therapeutic to a site of vascular injury. In this system, platelets target microencapsulated drugs through their natural aggregation behavior in the clot formation process and then deliver the drug by physically rupturing the …
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A comparative in vitro analysis of the Mobin-Uddin, Kimray Greenfield and Nitinol blood clot filters
Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 1982.
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High performance lattice boltzmann method yield-stress calculations based on intravital images of clot formation in live mice
… first image-based in-vivo assessment of blood clots viscoelastic nature. Furthermore, the outcome of our work can assist in creating simpler thrombogenesis models that can help improve the understanding of risk factors associated with blood clotting, and ideally help researchers to reduce risks …
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A Mechano-Chemical Computational model of Deep Vein Thrombosis
… Thrombosis (DVT) is the formation of a blood clot in a vein, usually in the body's lower extremities. If untreated, DVT can lead to pulmonary embolism (PE), heart attack and/or stroke, which can be fatal. According to literature, DVT affects 0.2% of people in developed countries and about …
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Viscoelastic haemostatic assays and fibrinogen concentration tests during haemodilution: The effects of fibrinogen and factor XIII
… Haemodilution with human albumin (HA) impaired clot strength (EXTEM MCF, maximal clot formation) less than the synthetic colloids hydroxyethyl starch (HES) or dextran (p<0.001), but equal with crystalloid fluids (normal saline, NA, or Ringer’s acetated solution, RA). Addition of fibrinogen …
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Clotting analysis of blood samples from intensive care unit patients.
… patients. Materials and Methods: Comparative clotting analysis was carried out on whole blood and plasma samples from twelve samples from intensive care unit patients. Nine haemophiliac samples and 14 healthy individual samples were used as controls. Several assays were used to assess …
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The Development of a Reduced Order Model for Prediction of Haemodynamic and Biochemical Changes in a Computational Cerebral Aneurysm Thrombosis Model
… with fibrinogen to produce fibrin and form a clot within the aneurysmal sac. The CFD results were used to build reduced-order models using machine learning algorithms. Multiple polynomial regression and logistic regression machine learning algorithms were used to predict clot size in patients. …
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Design and performance of hemostatic biomaterials for managing hemorrhaging
… being developed that: (1) generate artificial clots independent of the coagulation cascade or (2) interact with blood components to accelerate or otherwise improve coagulation processes. Hemostatic materials designed for internal bleeding can save lives in the battlefield, en route to emergency …
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Use Of Focused Ultrasound For Transcranial Sonothrombolysis
… how sonothrombolysis efficacy and potential clot fragmentation are impacted by varying the FUS intensity</p> <p>The observed, novel in vitro experiences using this new technology are very encouraging. From the four sets of experiments, we have learned that: 1) FUS sonothrombolysis is feasible …
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Thrombotic fingerprints for the enhanced prediction of thrombosis
… embolism, are all derived from unrestricted clotting. The frustrating aspects of these diseases lie not only in the difficulty of their timely diagnosis, but in the selection of appropriate therapy, titration of intervention, and identification of patients at risk. Assays like the INR, PTT, …
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Computational model of thrombosis in cerebral aneurysms for predicting clotting outcomes in flow diverter treated patient-derived geometries validated with novel PIV-based ln vitro clotting flow experiment
… Many thrombosis models include complicated clotting mechanisms, which can be computationally expensive, and present a challenge to comprehensively validate in vitro due in part to the complexity of adequately measuring the ongoing interaction between flow and clot-growth; a key factor in …
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A Quantitative Investigation of Selected Reactions in the Fibrinolytic Cascade
… (TAFI) was unable to prolong lysis of purified clots in the presence of Lys-plasminogen (Lys-Pg), indicating a possible mechanism for fibrinolysis to circumvent prolongation mediated by activated TAFI (TAFIa). Therefore, the effects of TAFIa on Lys-Pg activation and Lys-plasmin (Lys-Pn) …
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Proteases of the neutrophil membrane represent an alternative fibrinolytic pathway to that mediated by plasmin
… the neutrophil membrane might also be capable of clot dissolution. Investigations showed that neutrophil-mediated clot lysis was effected by a membrane-associated serine protease that can be dissociated by SDS-PAGE to bands that migrate to apparent molecular weights of 501 kDa, 398 kDa, 316 kDa, …
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A Minimally Invasive Ultrasound Therapy Based On Time- Reversal Acoustics For The Treatment Of Deep Vein Thrombosis
Deep Vein Thrombosis is a clotting disorder that usually leads to the formation of clots in veins deep within the legs. Deep Vein Thrombosis generally leads to a life threatening condition called pulmonary embolism where the clot breaks away and blocks the arteries of lungs. DVT affects about …
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A Study to Demonstrate the Immediate Destination of an Embolus Formed in the Lumen of a Peripheral Venous Catheter
… a peripheral vessel. The hypothesis stated that clots injected into a peripheral vessel will lodge in the lungs. A subhypothesis was that the clot may lodge anywhere along the circulatory pathway.</p> <p>Indications of need for the study as shown by the review of literature were the following: …
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Resonating Fluidic Circuits: A Novel Technology to Create a Portable Blood Viscoelasticity Measuring Device
… can diagnose coagulopathy by measuring blood clot viscoelasticity are portable, meaning that coagulopathy can only be diagnosed inside a well-resourced hospital. Resonating fluidic circuits are a promising technology to address this clinical need. In addition to being small enough to fit into …
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Treatment of brain cancer and ischaemic stroke utilising High Intensity Focus Ultrasound (HIFU) guide with MRI
… intensity results to higher volume of dissolved clot, but there is a limit of the intensity to be used in order to avoid heating of the clot and the surrounding tissue. The goal in this study was to achieve temperature elevation not exceeding 1ºC (called safe temperature). It was found that the …
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