Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 13 of 13 for “"Clonidine"”.
-
ΣΥΓΚΡΙΤΙΚΗ ΟΝΤΟΓΕΝΕΤΙΚΗ ΚΑΙ ΤΟΠΟΓΡΑΦΙΚΗ ΜΕΛΕΤΗ ΤΩΝ Α1, Α2 ΚΑΙ Β ΑΔΡΕΝΕΡΓΙΚΩΝ ΥΠΟΔΟΧΕΩΝ ΣΤΙΣ ΠΕΡΙΟΧΕΣ ΤΟΥ Κ.Ν.Σ. ΚΑΙ ΣΤΗΝ ΚΑΡΔΙΑ ΠΤΗΝΟΥ (GALLUS DOMESTICUS)
3H-WB4101, 3H-CLONIDINE AND 3H-DINYDROALPRENOLOL (3H-DHA) WERE USED FOR THE STUDY OF REGIONAL ONTOGENY AND LOCALIZATION OF A1, A2- AND B-ADRENERGIC RECEPTORS,RESPECTIVELY, IN CHICK BRAIN AND HEART. KINETIC STUDIES PERFORMED AT DIFFERENTEMBRYONIC AND POST- HATCHING AGES HAVE SHOWN ONE HIGH AFFINITY …
-
Central Alpha-Adrenoceptors and Behaviour
… effects. Agonists selective for α2 receptors clonidine, guanfacin and guanabenz, caused marked sedation, inhibited the pinna reflex, and were slightly analgesic. Clonidine also inhibited 5-HT-induced head twitches and haloperidol-induced catalepsy. In general, α1 agonists such as methoxamine, …
-
Pharmacological Reversal of Cognitive Bias in The Chick Anxiety-Depression Continuum Model
… 1 was conducted to ensure that drug treatments, clonidine and imipramine, do not substantially influence cognitive decision making to natural and ambiguous appetitive and aversive stimulus cues in the social treatment condition. Experiment 1 consisted of three socially tested groups (previous …
-
Dual Mechanism Analgesia-Enhancing Agents
… antinociceptive effects of an inactive dose of clonidine in the mouse tail- flick assay. An attempt to determine the underlying mechanism of this potentiating effect was the purpose of the present investigation. The studies focused on an examination of: i) MD-354 in the mouse hot-plate assay, …
-
ΚΑΡΔΙΑΓΓΕΙΑΚΕΣ ΜΕΤΑΒΟΛΕΣ ΑΠΟ ΤΗΝ ΕΝΑΠΟΘΕΣΗ ΝΟΡΕΠΙΝΕΦΡΙΝΗΣ ΚΑΙ ΚΛΟΝΙΔΙΝΗΣ ΣΤΟΝ ΠΥΡΗΝΑ ΤΗΣ ΜΟΝΗΡΟΥΣ ΔΕΣΜΙΔΑΣ ΤΟΥ ΠΡΟΜΗΚΗ ΜΥΕΛΟΥ ΜΗ ΑΝΑΙΣΘΗΤΟΠΟΙΗΜΕΝΩΝ ΕΠΙΜΥΩΝ ΚΑΙ Η ΕΠΙΔΡΑΣΗ ΤΗΣ ΓΕΝΙΚΗΣ ΑΝΑΙΣΘΗΣΙΑΣ ΣΤΙΣ ΜΕΤΑΒΟΛΕΣ ΑΥΤΕΣ
… THE LOCAL APPLICATION OF NOREPINEPHINE AND CLONIDINE TO RATS ANESTHETIZED WITH ETHER, URETHANE OR NEBUTAL, WE SHOWED THAT GENERAL ANESTHESIA MASKEDTHE CARDIOVASCULAR RESPONSES AND THEREFORE WE EXPLAINED OUR DIFFERENCES WITH THE PREVIOUS RESEARCHES.
-
Characterization of a novel recombinant inbred mouse model of high fear
… drug yohimbine and anxiety-relieving drug clonidine was used to determine if high fear mice show similar noradrenergic responses consistent with those seen in PTSD patients and PTSD animal models. The already fearful C3HLRI mice show increased fear and a fear extinction deficit when given …
-
Translational high-dimesional drug interaction discovery and validation using health record databases and pharmacokinetics models
… of omeprazole in the presence of fluconazole and clonidine was 9.35; and increased risk of myopathy was 6.41 (LFDR = 0.002) in FAERS and 18.46 (LFDR = 0.005) in EMR. We demonstrate that combining health record informatics and pharmacokinetic modeling is a powerful translational approach to detect …
-
Analysis of Neural Contributions to Ultradian Oscillations of Blood Pressure and Heart Rate in Dogs
… oscillations following the administration of clonidine, a centrally acting alpha$\sb2$ agonist, suggested that the central nervous system was involved in the genesis of these rhythms. Peripheral ganglionic blockade induced by hexamethonium bromide (10mg/kg/hr) significantly reduced the power …
-
Comparison of Receptor Efficacies on Vascular Smooth Muscle Contraction
… angiotensin II (AT<sub>1 </sub>agonist), clonidine (alpha<sub>2</sub>-adrenergic agonist) and moxondine (alpha<sub>2</sub>- adrenergic /I<sub>1</sub>-imidazoline agonist) on contraction in the rat-tail artery. Functionally, all these agonists cause contraction, but biochemically there are …
-
Factors Associated with Wean Duration Length as a Measure of Iatrogenic Withdrawal Syndrome in the Neonatal Intensive Care Unit: A Retrospective Chart Review
… cumulative doses of hydromorphone, lorazepam, clonidine, methotrimeprazine, and gabapentin were also associated with longer wean duration. Documentation of ethnicity was associated with longer wean duration. In the multiple regression model that included gestational age at birth, birth weight, …
-
Synthesis of Analogues Based on the Opioid Alkaloid Mitragynine
… buprenorphine (mu-partial agonist) and clonidine (alpha2-adrenergic agonist). Considering the negative aspects of the relapsing nature correlated to opioid dependence, it is important to search for new ways to overcome this problem. The scope of this work is to study novel compounds …
-
Stress-induced relapse to cocaine seeking in the rat : contributions of central nervous system corticotropin-releasing factor and noradrenaline
… of three alpha-2 adrenergic receptor agonists (clonidine, lofexidine, and gunabenz), which act to block NE cell firing and release, blocked footshock-induced relapse but were without effect on relapse induced by priming injections of cocaine. Together with results of the first series of …
-
Multidisciplinary management of Complex Regional Pain Syndrom Type 1 in children admitted to Red Cross War Memorial Hospital: A case series describing long-term effects on pain, function and quality of life
… infusion and varying combinations of gabapentin, clonidine and amytriptilline. One child received epidural local anaesthetic infusion. On average, pain scores improved by 67.8% by the time of discharge. At an average long-term follow-up interval of 10.3 months (ranging between 6 to 21 months), the …