Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Clonal Hematopoiesis"”.
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Investigating clonal hematopoiesis in rhesus macaque and human
Introduction <br>Clonal hematopoiesis (CH) describes the expansion of blood cell output from one HSPC linked to an acquired somatic mutation conferring a competitive advantage. While clonality is a feature of hematological malignancies, recent large deep sequencing studies have revealed that …
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The Effects of TET2-Deficiency on Neutrophil Gene Expression and Function
Background: Clonal hematopoiesis of indeterminate potential (CHIP), a potential precursor to myelodysplastic syndrome (MDS), affects over 10% of adults over 65. Loss-of-function ten-eleven-translocation methylcytosine dioxygenase 2 (TET2) variants are common in CHIP and associate with epigenetic …
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Clinical Utility and Impact of Targeted Nucleic Acid Sequencing in Myeloid Malignancies and Precursor Lesions
… several myeloid precursor lesions, such as clonal hematopoiesis of indeterminate potential (CHIP) and clonal cytopenias of undetermined significance (CCUS), have been linked to the development of myeloid malignancies. We propose that universal implementation of NGS in cases of suspicious or …
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EVALUATION OF THE RISK OF SECONDARY LEUKEMIAS IN CANCER SURVIVORS
… Chemotherapy may also play a role in increasing clonal hematopoiesis (CH), a clinical entity associated with a higher risk of developing hematological malignancies. Moreover, the presence of germline mutations in cancer predisposing genes can increase the risk of t-MNs. Our hypothesis is that …
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Orthogonal Comparison of Nuclear and Mitochondrial Clonal Architectures in Hematologic Malignancies
… hematopoietic differentiation and promote clonal expansion. Understanding how these mutations arise and evolve is essential for improving diagnosis, prognosis, and treatment stratification. Current methods are limited by either restricted genomic coverage (targeted panels) or low throughput …