Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 82 for “"Clonal Expansion"”.
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Insulin and TSH signal transduction pathways in human preadipocytes.
… cell lines has been attributed to a blockade of clonal expansion. We demonstrate that rapamycin inhibits the differentiation of human preadipocytes in primary culture, even though these cells do not undergo clonal expansion. Glycerol-3-phosphate-dehydrogenase (GPDH) activity, an indicator of …
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Telomeric Regulation of Chromosomal Instability In Colorectal Cancer
… CIN increased neoplastic cell competition and clonal expansion through accelerated differentiation of neighboring stem cells, resulting in increased number of adenomas and decreased survival in CIN-high <em>Apc<sup>min</sup> </em>mice. Mechanistically, CIN represses EZH2 leading to upregulation …
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Characterising the evolutionary dynamics of hypermutated tumours using single-cell sequencing
… studies of MMRD tumours showed that the clonality rather than the burden of mutations determines the variable responses to ICB observed in the clinic. Given that the clonality of mutations is determined by the evolutionary dynamics and patterns of intra-tumour heterogeneity, it is …
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Typing and genome comparison of Neisseria meningitidis by DNA-microarrays
… several genome alterations occurred before the clonal expansion of the ET-15 clone started. The role that these three genes play in the pathogenicity of the ET-15 clone is unclear. The genome comparisons revealed furthermore that studies of the ET-15 clone displayed approximately two-fold less …
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Molecular Mechanisms of Airway Epithelial Progenitor Cell Maintenance and Repair.
… and in some types of radiotherapy caused clonal expansion of club cells specifically in the most distal branches of the airway epithelium, indicating that the progenitors residing in the terminal bronchioles are radiosensitive. This clonal expansion is due to an increase in p53-dependent …
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Heterogeneity in vascular smooth muscle cell gene expression and its association with clonal proliferation in models of vascular disease
… in mouse models of vascular disease arises from clonal expansion of very few medial cells. The source of these cells and mechanism of their selection are unknown. Hypothesising that VSMCs which expand in disease would be distinctive within the healthy population, single cell RNA sequencing …
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Modelling the age-dependent dynamics of clonal haematopoiesis
… stem cells, this process, known as clonal haematopoiesis (CH), can often be detected years before the onset of haematological cancer, raising the possibility that individual cancer risk could be inferred from a routine blood sample. While recent studies have begun to quantify CH …
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The role of DEAD-box helicase 1 in humoral immune responses
… structures where affinity enhancement and B-cell clonal expansion occurs, following T-cell dependent immunisation. We discovered that GC-specific ablation of DDX1 resulted in reduced GC size with a reduction in antigen-specific B-cells, affinity maturation and clonal expansion, despite sufficient …
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Exploring the mutagenic consequences of inflammation and DNA damage
… as a result of heightened proliferation and clonal expansion. We also used the RaDR mouse model to expand upon studies of DNA repair pathway balance. DNA damage is addressed by a network of pathways, each designed to identify and repair specific types of lesions. One of the most important …
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A genome-wide, single-cell analysis of vascular smooth muscle cell plasticity
… plaques. Previous observations of clonal expansion of a small number of VSMCs in atherosclerosis suggested that VSMCs were functionally heterogeneous. I hypothesised that functional heterogeneity of VSMCs in disease may originate from VSMC heterogeneity in healthy arteries. In the …
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Single-cell approaches reveal functional and molecular heterogeneity in malignant haematopoietic stem cells
… these findings refine the molecules involved in clonal expansion of MPNs, and highlight the power of single cell approaches in deconstructing the functional characteristics and molecular network of normal and malignant stem cells.
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Ecology and population structure of vibrionaceae in the coastal ocean
… consistent with a scenario of stochastic clonal expansion, was especially pronounced in crab and zooplankton samples. Specialization, demonstrated by specific and reproducible association with different particle types in the water column, is more common than specialization within …
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The evolution of the autoantibody response in Graves’ disease
… Our findings raise the possibility that the clonal expansion of B cell populations that acquire autoreactivity in the periphery may be associated with the porin proteins of Y. enterocolitica.
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Evolutionary Genomics of Cystic Fibrosis and Nosocomial Pathogens of the Mycobacterium abscessus species complex
… ii) look for evidence of convergence after the clonal expansion of these lineages to understand how the MABSC was continuing to adapt and spread amongst people with CF and iii) to examine the within host evolution of these pathogens to uncover how these environmental organisms were adapting to …
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Quantitative dynamics of T-cell receptor repertoires and their use for cancer patient stratification
… TCRs that recognise cancer neoantigens undergo clonal expansion in peripheral blood and can be found at detectable clone frequencies. In this work, we explore the uses of quantitative analyses of longitudinal TCR repertoire samples in health and cancer to understand the clonal dynamics of TCR …
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The RNA-Binding protein PTBP1 plays a role in the activation of mouse CD8 T cells
… an antigen, CD8 T cells undergo cell growth, clonal expansion, and acquisition of effector functions. These steps are a result of controlled gene expression changes dependent on transcriptional and post- transcriptional mechanisms. These processes are tightly regulated, but little is known …
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Distribution of mutant cells in human skin : exploration of the fetal-juvenile mutability hypothesis
… initiator and a tumor promoter by favoring the clonal expansion of p53 mutated cells. By utilizing studies of the multiple genetic hit model of oncomutation and inference that preneoplasia appears to be a clonal continuation of juvenile growth in adult tissues from which one stem cell creates an …
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Lung carcinogenesis modeling: Resampling and simulation approach to model fitting, validation, and prediction
… for lung cancer. I propose to use a two-stage clonal expansion (TSCE) model to evaluate the effects of smoking on initiation and promotion of lung carcinogenesis. The TSCE model is traditionally fit to prospective cohort data. A new method has been developed that allows reconstruction of cohort …
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Mechanisms driving the expansion and progression of splicing factor-mutant clonal haematopoiesis
Clonal haematopoiesis (CH) describes the expansion of haematopoietic stem cells (HSCs) and their progeny due to the acquisition of somatic mutations. CH can be detected almost ubiquitously with advancing age and is associated with an increased risk of incident haematological malignancy and several …
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Characterisation of genetic complexity in chronic lymphocytic leukaemia
… the genomic complexity and molecular drivers of clonal expansion and maintenance of CLL using targeted next generation sequencing (NGS) and high resolution single nucleotide polymorphism (SNP) array. NGS analysis of the immunoglobulin variable heavy-chain (IgHV) in 497 pre-treatment CLL patients …
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