Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 585 for “"Clonal"”.
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How Clonal Ants Clone: The Reproductive Biology of the Clonal Raider Ant, Ooceraca Biroi
… in understanding the reproductive biology of the clonal raider ant, <em>Ooceraea biroi</em>. This species has lost the queen caste, and all individuals are, morphologically, worker females that reproduce asexually. Males are produced occasionally, but are considered effectively vestigial because …
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Modeling Clonal Evolution with Branching Processes
Clonal evolution in tumorigenesis assumes a tumor arises from a single ancestor cell followed by a sequence of mutations that increase fitness in clones. Waves of clonal expansions take place with each new mutation contributing to the selection of the cell. Not all mutations affect a clone's growth …
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Clonal Studies of Human B Cells
… to determine the specificity of about 2,300 clonal IgG antibodies produced by the progeny of single transitional and mature B cells. We show that in healthy individuals, half of the self-reactive B cells crossreact with foreign antigen, and that the frequencies of crossreactive B cells …
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The natural history of clonal haematopoiesis
… throughout life, some of which can drive clonal expansion. Such expansions are frequent in the haematopoietic system of healthy individuals and have been termed clonal haematopoiesis (CH). While CH predisposes to myeloid neoplasia and other diseases, we have limited understanding of its …
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Illuminating Clonal Dynamics: Development and Use of a High-Throughput Cellular Barcoding System to Track Clonal Evolution
It is increasingly recognized that tracking the clonal dynamics of large populations is important in understanding aspects of cancer and stem cell biology. Attempts to track the contributions of individual cells to the clonality of large homogenous populations, however, have been constrained by …
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A mathematical framework for clonal data analysis
… and their phenotype can be determined. The clonal data that result from this technique, however, are characterised by familial associations that impede their analysis using classical quantitative tools, necessitating the development of a new mathematical framework where suitable statistics …
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Studies of Clonal Populations of Nk65 Plasmodium Berghei
Made available in DSpace on 2014-12-14T16:11:15Z (GMT). No. of bitstreams: 1 7820904.pdf: 5529905 bytes, checksum: f9ee55555c529e1be3144561415c062c (MD5) Previous issue date: 1978
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Clonal dynamics of haematopoiesis across the human lifespan
… or blood loss; and increased risk of clonal haematopoiesis and blood cancers. The cellular alterations that underpin these age-related phenotypes, which typically manifest in individuals aged over 70, remain elusive. In my thesis I have aimed to investigate whether changes in HSC …
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Modelling the age-dependent dynamics of clonal haematopoiesis
… stem cells, this process, known as clonal haematopoiesis (CH), can often be detected years before the onset of haematological cancer, raising the possibility that individual cancer risk could be inferred from a routine blood sample. While recent studies have begun to quantify CH …
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Clonal Dynamics in Barrett's Oesophagus and Oesophageal Adenocarcinoma
… well studied for IM, little is known about the clonal dynamics in GM and OAC. Clonal dynamics can be explored through longitudinal or multi-sample genomic studies, or experimentally. There is no physiologically relevant in vivo model for BO/OAC, but patient derived 3D organoids may provide an …
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Investigating clonal hematopoiesis in rhesus macaque and human
Introduction <br>Clonal hematopoiesis (CH) describes the expansion of blood cell output from one HSPC linked to an acquired somatic mutation conferring a competitive advantage. While clonality is a feature of hematological malignancies, recent large deep sequencing studies have revealed that …
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Latent feature models and non-invasive clonal reconstruction
… and so a correct analysis must account for the clonal structure of the sample. Several methods to reconstruct tumour clonality from sequencing data have been proposed, spanning methods that either do not consider phylogenetic constraints or posit a perfect phylogeny. Models of the first type are …
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Clonal integration in Ochthochloa compressa under extreme environmental conditions
… multiple studies have indicated the benefit of clonal integration and its role in resisting harsh environmental conditions, many researchers have indicated the need for further studies to understand fully the role of clonal integration and what determines the optimal strategies in various …
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A Study of Clonal Senescence in A Ciliated Protozoan
Made available in DSpace on 2014-12-11T22:22:16Z (GMT). No. of bitstreams: 1 7212112.pdf: 2401718 bytes, checksum: bb7621b6758883d1f101653874d9339e (MD5) Previous issue date: 1971
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The human myeloproliferative disorders: molecular pathogenesis and clonal heterogeneity
… (PV) and idiopathic myelofibrosis (IMF), are clonal premalignant haematopoietic neoplasms associated with activating mutations in signalling pathway molecules and a variable tendency to develop acute myeloid leukaemia (AML). This thesis examined genotype-phenotype associations of JAK2 and MPL …
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Inferring Clonal Dynamics in Blood using Single-Cell Measurements
… follow their progeny over time to ask whether clonally related cells in myeloproliferative neoplasms (MPNs) favor particular blood cell fates. Myeloproliferative neoplasms are clonal disorders driven most frequently by the JAK2-V617F mutation, which arises in a single hematopoietic stem cell …
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Single-cell NAD(H) levels predict clonal lymphocyte expansion dynamics
… tunes discrete metabolic pathways to license clonal lymphocyte dynamics. Herein we identify NAD biosynthesis as a biochemical hub for the TCR affinity-dependent metabolome. Through its’ central anabolic role, NAD biosynthesis governs a quiescence exit checkpoint, pacing proliferation. …
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Clonal proliferation of hepatocytes during chronic hepatitis B virus infection.
… immune response, allowing them to undergo clonal proliferation. Clonal proliferation of altered hepatocytes may be a marker of disease progression and may have a direct role in the development of HCC. Liver tissues from 30 patients were analysed, including patients with early-stage HBV …
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