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Showing 1 to 9 of 9 for “"Clodronate"”.
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ISPH fusion proteins, ISPH inhibition, and bisphosphonate mechanism of action
… with CCl2 forming adenosine monophosphate (AMP)-clodronate. Given the high similarity of these metabolites to ATP, it seemed that these molecules might also inhibit kinases. ApppI and AMP-clodronate were screened against a panel of 369 kinases and potent inhibition of some tyrosine kinases by …
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Role of the macrophage in acute kidney injury
… or structural injury. In contrast liposomal clodronate mediated Mφ depletion provided functional and structural protection from injury. Administration of exogenous apoptotic cells also protected renal function if delivered 24h prior to IRI. Immunodeficient SCID mice exhibited a protected …
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Cellular Immunity in Mouse Models of Viral Encephalitis
… cells by intravenous liposome-encapsulated clodronate administration markedly suppressed the influx of leukocytes into the brain including CD8<sup>+</sup>VSV-specific T cells and enhanced morbidity/mortality despite normal viral clearance from the brain. Intracerebroventricular (ICV) …
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Allograft bone in hip revision: the effect of locally applied pharmacological treatment.
… to have the bone graft soaked in either clodronate—a bisphosphonate— or saline. DXA scans were performed postoperatively and at 3 and 12 months to evaluate the effect of the study drug. Radiostereometry (RSA) was performed postoperatively, after 6 weeks, and after 3 and 12 months, to …
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Defining Delivery Pathways of Nanoparticles
… the biggest barrier for targeted delivery. Next, clodronate-liposomes were used to remove the liver macrophages and showed that both nanoparticle tumour delivery and hepatobiliary elimination can be improved. Specifically, nanoparticle tumour delivery can be increased up to 50× and hepatobiliary …
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Impact of Temperature and Microbial Infection on the Honey Bee Hemocytes
… or pesticides impair hemocyte function. Using clodronate liposomes (CLD) to deplete hemocytes, we assessed how immune suppression interacts with these stressors.</p> <p>Methods</p> <p>Newly emerged (5-day-old) and older (15-day-old) bees were assigned to: CLD, control liposomes (LP), PBS, …
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The role of caspase-1 in liver and adipose tissue during metabolic dysregulation in mouse models on NASH
… Deletion of macrophages in the liver by clodronate liposomes suppressed caspase-1 activation and demonstrated a protection from MCD-induced inflammation and fibrogenesis, suggesting that caspase-1 in Kupffer cells plays an important role in NASH pathogenesis. Casp1-/- mice on the high fat …
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PRECLINICAL PET IMAGING FOR TUMOUR CHARACTERIZATION: FOCUS ON HYPOXIA AND INFLAMMATION
… to be safe and effective, i.e. administration of clodronate encapsulated into liposomes. Sham-liposomes were used in control animal cohorts. Using [18F]FDG-PET we detected and monitored peritoneal lesions’ growth, with a good correlation between the real neoplastic lesions extension and that …
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Zum Potential des Bisphosphonat Clodronat bei der zyklischen Therapie der primären Osteoporose
23 Patienten mit primärer Osteoporose erhielten über 1 bzw. 2 Jahre eine zyklische, niedrig dosierte Therapie mit 800 / 1600mg Clodronat p.o. über 30 d / 90 d. Ergebnisse: Unter Clodronat kam es zu einer signifikanten Zunahme der lumbalen Knochendichte ( bis zu 6%), die periphere Knochendichte …