Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Clock gene expression"”.
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Impairment in mitochondrial oxidative phosphorylation alters clock gene expression
… to jet lag, disrupt our normal 24- hour internal clock or circadian rhythm. The molecular mechanisms that link chronic circadian disruption to disease are not well understood. Since light exposure at night is known to decrease melatonin levels, some researchers have hypothesized that a reduction …
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EVALUATING THE CHEMOTHERAPEUTIC EFFECTS OF SR9009 AND ESOMEPRAZOLE ON ORAL SQUAMOUS CELL CARCINOMA USING CIRCADIAN-TAILORED INNOVATIVE THERAPEUTIC APPROACHES
… New potential triggers, including circadian clock disruption that is caused by multiple lifestyle traits such as chronic gastroesophageal reflux and human papillomavirus (HPV) infection are emerging new causal factors that might be responsible for higher population incidence of OSCC among …
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The role of serotonin-2C receptors in the rat circadian system.
… of 5-HT2C receptor agonist administration on clock gene expression were investigated in the rat SCN. Systemic administration of the 5-HT2A/2C agonist DOI to rats during early night induced c-fos, Per1 and Per2 expression in a manner similar to light. This response was time of day dependent …
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Coordination of the Arabidopsis thaliana circadian clock
Individual plant cells have a genetic circuit, the circadian clock, that times key processes to the day-night cycle. These clocks are aligned to the day-night cycle by multiple environmental signals that vary across the plant. Thus, the clock may be set separately in cells creating discrepancies in …
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Circadian Secretion of Glucagon-like Peptide-1
… which have been found to express cell-autonomous clocks that are entrained by food intake, are largely responsible for establishing diurnal metabolic homeostasis. The incretin hormone glucagon-like peptide-1 (GLP-1) enhances glucose-stimulated insulin secretion following nutrient ingestion and has …
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Chronic Circadian Misalignment Disrupts the Circadian Clock and Promotes Metabolic Syndrome
… misalignment of an organism’s internal circadian clock with diurnal, cyclic changes in the external environment, prevalent in professions that require shift work, contributes significantly to Type 2 Diabetes development. Experimentally, only short-term models of circadian disruption have been …
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Cannabinoid CB1R Receptor Mediates Metabolic Syndrome in Models of Circadian and Glucocorticoid Dysregulation
… as regulated by the master circadian (daily) clock in the suprachiasmatic nuclei ( SCN). Signaling in this regard is at least partially responsible for entraining circadian clocks outside of the SCN. Just as shifts in glucocorticoid exposure are associated with metabolic disturbances, …
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Crosstalk Signaling Between Circadian Clock Components and Iron Metabolism
… through diet, yet little is known about how the clock governs iron metabolism. The regulation of iron within the cell is very tightly controlled, as iron is highly reactive in the generation of oxidative stress and the excretion of excess iron is very limited. There are limited findings …
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The Role of Circadian Clock in the Embryonic and Post-Natal Development and Pathophysiology of Oral Tissues and Implications of Natural Treatments in Dental Caries Progression
… potential systemic implications. The circadian clock, an endogenous intracellular mechanism, assumes a pivotal role in orchestrating physiological processes across various bodily organs including bone, teeth, and salivary glands. It is noteworthy that circadian mechanisms may also play a role in …