Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Clinical validity"”.
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Assessment of the clinical validity of ctDNA Analysis for melanoma management
… immune-checkpoint inhibitors has improved the clinical management of melanoma, but durable survival benefit is only seen in a minority of patients. The use of these very expensive systemic therapies on all appropriate patients also poses a high economic burden on health systems across numerous …
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Risk Prediction and Value of Polygenic Risk Scores in Colorectal Cancer Screening
… to improve PRS risk prediction are needed for clinical use, and understanding its added value of guiding CRC screening is needed to inform screening guidelines, clinical adoption, and reimbursement decisions. In Chapter 1, we assessed whether the clinical validity of PRS risk prediction models …
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Scoring Sentences Developmentally: An Analog of Developmental Sentence Scoring
… of the SSD software to determine its clinical validity and reliability. Results of this study suggest that SSD has the potential to compliment other analysis procedures in assessing the language development of young children.
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Advances in the assessment and rehabilitation of older adult fallers
… in differing age groups and to assess its clinical validity. A novel multi-task directed stepping test was designed and piloted to investigate changes in volitional directed stepping when performing complex spatial tasks (Chapter 3). Changes in prioritisation of postural tasks with older …
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Understanding Socio-Cognitive Impairments in Parkinson's Disease: from Behavioural to Neuroimaging Characterisation
… the comprehensive understanding of its intricate clinical presentation remains to be further investigated and more precisely delineated. A substantial body of evidence from existing literature has consistently demonstrated the presence of non-motor symptoms in patients with PD, including deficits …
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Workload tools used in emergency departments: A scoping review
… studies were summarised focusing on the tools validity, reliability and transferability, and then discussed in relation to the current New Zealand emergency department healthcare environment. CONCLUSION No one workload tool was identified as being effectively utilised in international emergency …
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Assessing Genetics Providers' Perspectives of and Experiences with DTC Genetic Testing: Creation of an Educational Module
… for disease susceptibility. Concerns about the clinical validity and utility of DTC genetic testing have arisen as well as potential misinterpretation of results by consumers. Furthermore, several studies have confirmed that healthcare providers are not well-educated about DTC genetic testing …
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Automated Radiotherapy Treatment Planning for Breast Cancer: A Robust to ol for Global Deployment
… reviewed by physicians to determine clinical acceptability. Five automated conventional planning approaches were developed, complemented by an established RapidPlan model for volumetric arc therapy. These included conventional tangents for whole-breast treatment, variations for …
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Health and the Spiritual Self: Development and Application of a Theory and Measure of the Process of Healthy Change
… perform preliminary tests of the reliability and validity of this measure. The third study used quantitative methods with 233 participants to evaluate more robustly the reliability, content and concurrent validity of the original developmental measure and another, behaviourally-orientated …
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Development and evaluation of methodologies for analysis of CTC and ctDNA in patients with ovarian carcinoma
… of tumour biopsies is the gold standard in clinical practice with the purpose of evaluating specific biomarkers to predict therapeutic response. However, this is invasive, and associated complications may occur. Liquid biopsy is a minimally invasive test and has the advantage of allowing …
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Development and validation of risk prediction model for colorectal cancer in patients with gastrointestinal symptoms
… and impact studies (evaluation of the model’s clinical validity and utility). It is of great clinical importance to identify risk factors with substantial predictive value, develop and validate risk prediction models with strong prediction performance, and improve risk prediction models’ …