Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 45 for “"Clinical validation"”.
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Clinical validation of SARS-CoV-2 RT-LAMP in animals
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2025-10-19 without embargo terms
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A Clinical Validation of the Obsessive Compulsive Consequences Scale-Revised
… Two studies were conducted to evaluate the clinical utility of the Obsessive Compulsive Consequences Scale-Revised (OCCS-R) and increase understanding of the relationships between the prognostic factors of motivation, insight, treatment compliance and treatment outcome. Study 1 used maximum …
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A Multiscale Model for Breast-Conservative Therapy: Computational Framework and Clinical Validation
… mathematicians and computer scientists. A clinical protocol that involves patients eligible for BCT was developed in order to validate this multiscale model with clinical data. The results obtained show the performance of the model and our findings based on the data of the first patient who …
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Development of musculoskeletal models for the design and the pre-clinical validation of hip resurfacing prosthesis
… of the implant quality is poorly pre-clinically addressed. Thus revision is the only delayed and reliable end point for assessment. The aim of the present work was to model the musculoskeletal system so as to develop a protocol for predicting failure of hip resurfacing prosthesis. …
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CLINICAL VALIDATION OF 371 MICRO-RNA USE IN SMALL TESTICULAR MASSES AND IN STAGE IIA AND IIB<3CM TESTICULAR GERM CELL TUMORS
… a model of curability of solid tumours. However, clinical management and follow-up of both localized and locally advanced TGTCs is still complex and the risk of treatment delay or, conversely, of overtreatment is high. According to this assumption we focused on two different TGCTs patients …
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Proteomic identification of putative biomarkers of neo-adjuvant chemotherapy resistance in luminal (ER+) breast cancer
… A pilot series of archival samples was used for clinical validation of putative predictive biomarkers.Results:89 differentially expressed proteins (DEPs) were seen in the 4 further AbMA experiments. In the combined dataset (12 experiments from 2 proteomic platforms), 8 DEPs were seen in at least …
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De novo designed protein switches to enable increased specificity of targeted therapeutics
… components required in our original system make clinical validation complicated.Through design of new protein switches and incorporation of de novo proteins designed to directly engage and activate immune cells, we have developed a simplified system for selectively killing cancer cells without …
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Functional In Vivo Screen Identifies Pygo2 As A Putative Gene to Promote Prostate Cancer
… hit for further <em>in vivo</em> functional and clinical validation. Overexpression of PYGO2 could enhance primary tumor growth as well as local invasion to lymph nodes using AR-positive prostate cancer cell line LNCaP. PYGO2 may mediate its pro-tumor function through upregulation of genes …
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Estimating Target Vessel Location on Robot-Assisted CABG using Feature-based CT to US Registration
… has been validated via both an in vitro and a clinical study, and predicted the position of the peri-operative target vessel location with ~ 3.5 mm RMS accuracy in the in vitro study while it yielded ~ 5.0 mm accuracy for the clinical validation. As the desired clinical accuracy imposed by this …
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Assessing Blood-Based Laboratory Diagnostics for Alzheimers’s Disease: A Systems Approach
… alternative, yet they remain underutilized in clinical practice. By conducting a literature review, stakeholder interviews, and a Kano analysis, the thesis identifies and evaluates the key stakeholder needs to support the widespread adoption of these tests, such as the need for demonstrated …
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Correlation and real time classification of physiological streams for critical care monitoring.
… data streams through the development of clinically meaningful alerts using a blend of expert knowledge in the domain and pattern recognition programming based on clinical rules. Its relevance is demonstrated via a real world case study within the context of neonatal intensive care to …
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Fine-tuning CLIP models for peripheral blood cell images retrieval based on morphological descriptions
… refining captioning strategies, and clinical validation.
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Model Validation and Inversion of Active Implantable Medical Devices
The model validation and inversion for active implantable medical devices (AIMD) used for safety evaluations under magnetic resonance imaging (MRI) radio frequency (RF) coil emission were discussed. A mathematical derivation is presented to provide guidance on selecting meaningful pathways for the …
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The Effect of Mebendazole and RAN Mediated Pathways on Human Breast Cancer Cells
… This study presents significant steps toward the clinical validation of Mebendazole as a combination therapy for reducing the invasion and metastasis of breast cancer cells.
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Validation of the Defining Characteristics of Disturbance in Self-esteem in Patients with Anorexia Nervosa
… characteristics should be further researched in clinical validation studies.</p>
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Personalized Biomechanical Heart Modeling for Clinical Applications
… experimental data, and the investigation of clinical applications with patient-specific modeling.<br/><br/>At the 1D level we aimed at reproducing physiological experiments with myocardial fiber contraction. For the 3D validation we performed in co-operation with a clinical partner an …
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Advanced Projection Ultrasound Imaging with CMOS-based Sensor Array: Development, Characterization, and Potential Medical Applications
… geometry. In summary, while awaiting additional clinical validation, the C-scan ultrasound prototypes with the state-of-the-art PE-CMOS sensor arrays can provide veritable value and holds real and imminent promise in medical diagnostic imaging. Potential future uses of C-scan ultrasound include …
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An Exploration of the Role of African Traditional Health Practitioners in Treating Cancer Patients: A Case Study of Mzinti, Mpumalanga Province of South Africa
… in treating cancer patients and the lack of clinical validation of traditional medicine. This study used a qualitative research design and perceptions were gathered through semi-structured interviews and focus group discussions. There were 16 participants who included 7 traditional health …
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