Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"Clinical trials--Design"”.
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The Limb-Leaf Design: A New Way to Explore the Dose Response Curve in Adaptive Seamless Phase II/III Trials
… of our work is adaptive seamless Phase II/III trials and a systematic Limb-Leaf Design is developed. In a case of a nonmonotonic dose response curve where the desired level of effect exists in only a narrow dose range, a simulated comparison between a Limb-Leaf Design and a standard (Thall, …
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The role of antibiotics in preventing infection and its complications in dental surgical procedures
… (DIP). Method: This study utilised two main designs systematic review and meta analysis and a survey of dentists’ practice opinions. Following PRISMA-P© methodology, two systematic reviews of randomised controlled clinical trials were designed and registered on the PROSPERO© database. …
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Further Advances For The Sequential Multiple Assignment Randomized Trial (Smart)
… multiple assignment randomized trial (SMART) designs have been developed these years for studying adaptive interventions. In my Ph.D. study, I mainly investigate how to further improve SMART designs and optimize the interventions for each individual in the trial. My dissertation has focused on …