Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 261 for “"Clinical significance"”.
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Clinical significance of certain electrolyte disturbances
Typewritten copy
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Antibodies to acetylcholinesterase: their detection and clinical significance
… had occurred since much of the early work. These clinical studies produced data that indicated that anti-acetylcholinesterase antibodies are not prevalent in these disorders, which was not consistent with previous findings.<br/><br/>However, the data generated did reveal that IgG autoantibodies of …
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CatSper: Characterisation in Human Spermatozoa and Clinical Significance
… to cryodamage, which may be of significant clinical relevance, due to the common use of cryopreservation of semen in ART. The present study also describes the novel use of single cell calcium imaging as a sensitive screening tool for calcium defects in healthy volunteer donors, IVF and ICSI …
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Clinical Significance of Rheumatoid Factor in Rheumatoid Arthritis
… This purpose of this study is to evaluate the clinical characteristics and treatments of RA according the presence of RF in Korean. MATERIALS AND METHOD: A retrospective analysis was performed on the records of 109 patients followed at least 2 years at Ajou University Hospital among 230 RA …
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Variants of Uncertain Clinical Significance In Pediatric Microarray: Parent Perspectives
<p>Introduction: Variants of uncertain clinical significance (VUS) are commonly encountered in genomic evaluation, such as microarray testing. Such a result can be unsettling for both laboratory professionals and clinicians. As newer, more detailed genomic technologies integrate into pediatric …
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Hemoglobin Alc: Structure, Biosynthesis and Clinical Significance In Diabetes Mellitus
… has been to increase our understanding of the significance of increased hemoglobin A1C concentrations in diabetics. The studies described here in the diabetic mouse demonstrate increased hemoglobin A1C to be a marker for the diabetic phenotype regardless of the cause of diabetes. The increase …
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Renal Drug Transporters – Clinical Significance and Role in Drug-Drug Interactions
… interactions (DDIs) have become a significant clinical concern as they can adversely impact drug disposition, efficacy, and toxicity. The overall goal of my research project is to understand the clinical significance of renal drug transporters and their role in drug-drug interactions. An …
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Clinical Significance of Homologous Recombination Deficiency Score Testing In Endometrial Cancer
… was queried to determine frequency and clinical significance of alterations in the HR pathway in endometrial cancer. 137 formalin-fixed paraffin-embedded endometrioid adenocarcinoma patient samples were tested for HRD score, microsatellite instability (MSI) and high mutation load (HML) …
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Biological and Clinical Significance of Circulating Tumor Cells in Breast Cancer
… aspects of metastasis biology and finding new clinically relevant biomarkers. On the hypothesis that CTCs possess a distinct profile compared to solid primary and secondary lesions, the transcriptome of experimentally-derived CTCs was compared with those of the primary tumor (PT) and metastases …
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The Clinical Significance of Fungal Allergy in Patients with Atopic Dermatitis
… 아토피피부염의 임상적 중증도는 국제적으로 표준화된 중증도 지표인 standardized clinical scoring system for atopic dermatitis (SCORAD) 지수를 이용하여 평가하였다. 알레르겐 특이 IgE 항체가 3.5kU/L(CAP class 3)이상인 경우, 그 알레르겐에 대해 유의한 알레르기를 보이는 것(감작상태)으로 판정하였다. 아토피피부염 환자들에서 특정 알레르겐에 대한 감작률은 D. farinae 65.0 %, D. pteronyssinus 63.5%, M. furfur 50.9%, C. …
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Immune Infiltrates in Breast Cancer: Clinical Significance from Histopathology to Prognosis
… with better outcomes. However, the prognostic significance of TILs varies by TIL type, with CD8+ (cytotoxic T-cells) generally being associated with better outcomes, and both FOXP3+ (T-regulatory cells) and CD163+ (M2 macrophages) TILs being associated with worse outcomes. However, there is …
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Cone Beam Computerized Tomography Analysis of Haller cell : Prevalence and Clinical Significance.
… respectively.</p> <p>There was no statistically significance between HC, size of HC, size of maxillary sinus ostium with MS. HC and OD showed strong statistically significance.</p> <p><strong>Conclusion</strong> HC prevalence was high. No association of HC between presence, size and MS could …
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The detection and clinical significance of TP53 dysfunction in chronic lymphocytic leukaemia.
… of patients. This project aims to assess the clinical value of the etoposide/nutlin3a functional assay for detecting abnormalities of the p53- dependant DNA damage response which would contra-indicate treatment with DNA damaging drugs in samples referred from around the UK . A total of 472 …
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Clinical Significance of Pattern of Memory Deficits in Amnestic Mild Cognitive Impairment
… CTO. Baseline demographics, characteristics and clinical/radiologic outcomes were compared. Poor prognosis was defined as modified Rankin Scale (mRS) 5 and 6 at 3 months. We evaluated whether MCA plus group would be a ‘stop sign’ of further endovascular treatment for acute CTO by analyzing …
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Pathogenesis and clinical significance of AIDA-I-positive E. coli in diarrhea of pigs
… adhesin in the pathogenesis of diarrhea and the clinical significance of the AIDA-I E. coli virotype are unknown in humans or in animals. First, in order to evaluate the role of AIDA-I adhesin, colostrum deprived newborn pigs were infected with: i) a wild strain PD20 (AIDA-I+/STb+) E. coli; ii) a …
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The clinical significance of the erythrocyte sedimentation rate with special reference to pulmonary tuberculosis
… methods of estimation and interpretation or the clinical value of the test. This thesis will deal only with practical considerations. Theories as to the mechanism of sedimentation will not be discussed.
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