Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"Clinical progression"”.
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Qualifying the Variability of Surface Topography Indices for Detection of Clinical Progression of Scoliosis
… These ST measurements must be evaluated within a clinical context to determine their feasibility for clinical and research applications. This study quantifies the variability in a set of developed ST indices and estimates a magnitude of clinically important difference based on current clinical …
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Mechanisms of Late-Delayed Radiation-Induced Brain Injury: Insights from Extracellular Matrix and Transcriptional Profiling
… and white matter injury. Although the clinical progression and morphology of late-delayed radiation-induced brain injury (RIBI) are well characterized, the pathogenesis is unclear. The long-term consequences of single high dose irradiation of the adult brain, as may occur following a …
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In vivo pathology markers in tauopathies: prognostic and diagnostic implications
… neuroinflammation plays a role in the onset and progression of these diseases, rather than simply being a response to neuronal injury. PET and MRI allow the in vivo visualisation and quantification of markers of neuropathology and neurodegeneration. However, the value of these in vivo measures at …
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Predicting the risk of progression in patients with thoracic aortic aneurysm
… to identifying biomarkers of aneurysm progression. Despite these challenges, I have created a unique dataset quantifying plasma proteins and PBMC-RNAs in a cohort of 50 AD patients with measurements of growth or clinical progression over 2 years. Analysis of my dataset indicates that: …
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Machine Learning Approaches for Characterizing ALS Disease Progression
… in its onset, pattern of spread, and disease progression. This heterogeneity makes it challenging to identify potential therapeutics and to evaluate their effectiveness in slowing progression. At the same time, a better understanding of the heterogeneity of ALS might help identify …
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The Impact of Genetic Testing in Women with a Diagnosis and Family History of Breast Cancer: A Qualitative Investigation of Patient Experience
… including risk-reducing interventions.<br/>Clinical progression towards early genetic testing to inform treatment for newly diagnosed hereditary breast cancer appears to be acceptable and feasible. The offer of a genetic test at the time of diagnosis is new in the field of cancer genetics, …
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Quantifiable MRI changes in cerebral white matter and their importance to aging, cognition, and Alzheimer's disease
… evidence that WMSA are known to influence the clinical progression of AD, we do not currently view AD as a vascular disease nor do we use WMSA as a clinical indicator of AD. This is because we still do not know whether or not WMSA are a distinct phenomenon in AD, their relationship to …
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Medical Microbiology: Discovery of New Antimicrobial Drugs to Treat Clinically Relevant Antibiotic Resistant Pathogenic Bacteria
… bacterial isolates were obtained from various clinical and environmental samples, including those provided by members of the general public. These isolates were screened for antimicrobial production using various antagonism assays. Draft genomes of 26 selected antagonistic strains were …
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Application of machine learning to the detection and prediction of Parkinson’s disease subtypes
Background: The clinical manifestations of Parkinson’s disease (PD) are characterized by heterogeneity in age at onset, disease duration, rate of progression, and the constellation of motor versus non-motor features. As such, counseling of patients about their prognosis is guarded. Characterization …
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Using genotypic and phenotypic methods to determine the HIV co-receptor phenotype in the clinical setting
… phenotypic assays for co-receptor usage in the clinical setting and investigate approaches for improvement of these assays. Methods: The concordance of recombinant co-receptor phenotyping assays and the predictive ability of genotype-based methods including the ‘11/25’ rule, position specific …
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Molecular Coordination of Skeletal Muscle Capillary Remodeling in Obesity: Implications for Metabolic Homeostasis and Disease
… therapeutic strategies against obesity and its clinical sequalae that now pose a significant public health and economic burden on healthcare systems worldwide. The skeletal muscle capillary network has emerged as a critical determinant of metabolic homeostasis and structural remodelling of this …
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The role of eukaryotic initiation factor 4E (eIF4E) in osteosarcoma metastasis
… disease. Emblematic of the problem is the clinical progression seen in most patients with osteosarcoma, where metastasis to the lung is the most common cause of death. The primary research need in the field is to understand the biology of metastasis in osteosarcoma so as to improve outcomes …
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Aggregation & Localization of a Disease-Associated Prion Protein (PrP) Mutant
… PrP mutant. Whether the GPI anchor affects clinical progression of familial prion disease remains to be determined. Our analysis provides foundational information for the continued study of the role of the GPI anchor in familial prion disease pathogenesis.
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Neuromuscular control adaptation during recovery from injury
… By combining dynamical-systems modeling and clinical experimentation, this work attempts to explore and explain discontinuous changes in neuromuscular control, as well as the possibility of coexisting longitudinal neuromuscular control paths, during recovery from injury. The specific aims are …
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Progression and variation of Progressive Supranuclear Palsy
… over the optimal outcomes in early-phase clinical trials. Natural history studies can facilitate readiness for trials, with better diagnostic schema, validated biomarkers, and information on critical variability in phenotype and stage of disease. In this thesis, I test whether clinical …
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Modeling Alzheimer's Disease in Induced Pluripotent Stem Cells
… this seminal work, the mechanisms underlying the clinical progression of AD is still poorly understood. This gap in our knowledge is due, in large part, to the lack of appropriate AD disease models. Specifically, rodent models of human neurodegenerative disease fail to completely recapitulate …
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Role of the Type III TGF-beta Receptor Cytoplasmic Domain in Breast Cancer Progression
… is an important modulator of breast cancer progression, acting in a tumor suppressing fashion in early carcinogenesis but switching in a poorly understood fashion to a promoter of cancer progression in later stages. Mutations and loss of function of TGF-β components are common across a …
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HIV-Polymyositis progressing to inclusion body myositis: clues to earlier diagnosis
… diagnosed as HIV-associated PM (HIV-PM) clinically and on muscle biopsy, change into a treatment-resistant HIV-IBM clinical phenotype. These cases are referred to as HIV-PM/IBM overlap syndrome. In recent years at Groote Schuur Hospital (GSH), we have also encountered patients with …
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Examining endothelial function in humans in vivo: improving guidelines and exploring novel measures
… disease patients, to further investigate to clinical potential of the CAR test. In Chapter 4 we explored the relation of CAR with cardiovascular risk, followed by assessing the similarity in response to sympathetic stimulation between the carotid artery and coronary arteries. We first …