Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 55 for “"Clinical models"”.
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Executable clinical models for acute care
… best available evidence. An \textit{integrated clinical guidance system} can reduce such medical errors by helping medical staff track and assess patient state more accurately and adapt the care plan according to the best practice guidelines. However, a main prerequisite for developing a …
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Tissue-Engineered Annulus Fibrosus Repair and Nucleus Pulposus Augmentation in Pre-Clinical Models of Intervertebral Disc Degeneration
Intervertebral discs (IVDs) are the cartilaginous structures in the spine that connect adjacent vertebrae, absorb shock from daily activities, and allow for articulation of the spine. Unfortunately, IVDs are prone to degeneration and have little to no capacity for self-repair. IVD degeneration is …
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Machine Learning Methods for Image-based Personalized Cancer Screening
… patient care, the development of equitable clinical AI models and their translation to hospitals remains difficult. From a computational perspective, these tools must deliver consistent performance across diverse populations and adapt to diverse clinical needs, while learning from biased and …
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Targeted therapies in mantle cell lymphoma
… part to its late classification as a separate clinical entity leading to a dearth in available pre-clinical models. The specific objectives of the research described in this thesis were (1) to establish MCL preclinical models of disease and (2) to evaluate deregulated cell signaling pathways in …
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Towards unified biomedical modeling with subgraph mining and factorization algorithms
… subgraph mining and factorization algorithms to clinical narrative text, ICU physiologic time series and computational genomics. These algorithms aims to build clinical models that improve both prediction accuracy and interpretability, by exploring relational information in different biomedical …
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Identifying Molecular Targets and Validating Novel Therapies For Ovarian Cancer
… predicts the beneficial therapeutic effect of clinically relevant targeted therapies and the downstream pathways they may impact in the cancer of interest. Using ovarian cancer as a model to biologically validate our tool, we determined that Bromodomain and Extra-Terminal motif inhibitors …
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HISTONE LYSINE METHYLTRANSFERASE NSD3 GOVERNS TRANSCRIPTIONAL PROGRAMS THAT DRIVE PANCREATIC NEUROENDOCRINE TUMORS (PANNETS)
… for PanNET patients. Additionally, pre-clinical models that more accurately represent disease are an urgent necessity for translational studies.</p> <p>This dissertation directly addresses these challenges by identifying histone lysine methyltransferase (KMT) NSD3 as a critical oncogenic …
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Yap1 Expression Predicts Sensitivity to Dual Akt/P70S6K Inhibition In Ovarian and Uterine Malignancies
… Design: </strong>Orthotopic murine models of ovarian and uterine cancer were utilized to study the effect of MSC2363318A on survival and regression. Moreover, <em>in vitro</em> experiments (MTT, Western blot analysis, plasmid transfection, and reverse phase protein array [RPPA]) were …
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Impact of Tumor Cell Expressed CD38 on Metastasis and Immune Evasion in Breast Cancer
… immunesuppressive molecule associated with worse clinical outcomes in liquid malignancies but relatively understudied in solid tumors such as breast cancers. Hence, we sought to investigate the role of CD38 in hybrid EM-driven metastasis using pre-clinical models of TNBC. We observed that altering …
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Delineating Trauma Mechanisms and Interventions: How Psychological Trauma Difficulties Develop and how they can be Treated Effectively
… the effect size of phase-oriented treatment models. Findings indicated a large effect size in the reduction of PTSD symptoms, which was maintained when compared to control groups and when a complex sub-group was isolated. The findings lend evidence to the efficacy of this treatment approach …
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Validation of AXL as a Therapeutic Target in Pancreatic Cancer
… sequencing of PDA genetically engineered mouse models reveals that AXL is expressed highly in tumor cells that have a mesenchymal-like phenotype and AXL expression correlates with classic markers of mesenchymal tumor cells. This AXL-positive mesenchymal PDA cell population is critical for PDA …
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Real time PCR and fluorescent in situ hybridization in the detection of the physical tsate of human papillomavirus 16 and 18 in paraffin embedded cervical tissue
… of HPV integration is essential in informing clinical models for early intervention and therapies. We therefore sought to determine the feasibility of real time-PCR (RT-PCR) as a molecular tool in detecting the physical state, episomal versus integration of HPV 16 and 18 DNA in cervical …
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The Relationship Between Co-Dependence and Borderline Personality Disorder
… by Dr. E. G. Goldstein in Borderline Disorders: Clinical Models & Techniques (1990). Two self-report, anonymous instruments were used; one was completed by clinicians and the other by persons who self-identify as co-dependent or were so identified by a relative, friend, or counselor.</p> …
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Towards an explicitly theocentric model of forgiveness based on God's two-fold commandment to love
… major theological omissions of the prevailing clinical models of forgiveness---the centrality of God, doctrine of sin, and primacy of Jesus Christ. Then, the theocentric definition of forgiveness is used to address and develop the twelve aspects of forgiveness, looking also at the communal …
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Characterization of the Dunkin Hartley guinea pig as a non-transgenic and multimorbid model of brain aging
… is conducted using genetically engineered pre-clinical models, that express a specific brain aging pathology. Recent discoveries, however, have identified a dynamic whole-body "inflammaging" phenotype that exists with, and likely contributes to, AD/ADRD onset and progression. Currently, we do …
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Characterisation of genetic and epigenetic aberrations in paediatric high grade glioma
… in part due to lack of well-characterised pre-clinical models, is a great challenge in the development of novel therapies. Analysis of paired cell culture/biopsy samples in this study revealed that paediatric HGG short-term cell cultures retain many of the tumour characteristics in vivo. Using …
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Treatment During Abstinence from Methamphetamine in a Rat Model of Methamphetamine Use Disorder
… well as having anti-inflammatory action. In pre-clinical models, phosphodiesterase inhibitors can reduce behaviors associated with the self-administration of drugs of abuse if given directly before tests of relapse-like behavior. However, they have not been examined in the more clinically …
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Archiving the trauma diaspora: Affective artifacts in the higher education arts classroom
… narratives may emerge. Drawing upon cultural and clinical models of trauma, feminist pedagogical ethics, queer theory, and cultural archiving theory to advance the notion of a “trauma diaspora” that becomes known through an affective archive. Through close contextualized reading of classroom …
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Learning from Structured Data with Weak Supervision
… self-supervised learning methods that train models on broad data at scale without pre-defined labels, geometric deep learning that leverages structure and geometry informed by scientific knowledge, and generative AI methods that create action plans for experiments and produce new designs such …
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An integrated decision support model for the sustainable refurbishment of hospitals and healthcare facilities: developing a prototype.
… the diverse built estate, and the ever-evolving clinical models of care. The economic downturn, and strict policy of austerity in the UK, presents limitations and challenges in capital investment. The majority of healthcare facilities which will be used throughout the 21st century, have already …
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