Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 156 for “"Clinical isolates"”.
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Enzyme Mediated Gentamicin Resistance Among Gram-Negative Clinical Isolates
… the incidence of resistance to gentamicin among clinical isolates (of formerly susceptible bacteria) is on the rise (7-12). Resistance to the aminoglycosides is believed to be due to three basic mechanisms (13,14), The best characterized mechanism is the enzyme-mediated inactivation of antibiotic …
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Characterization of Metronidazole- and Vancomycin-Resistant Clinical Isolates of Clostridium Difficile
… of Metronidazole- and Vancomycin-Resistant Clinical Isolates of <em>Clostridium difficile</em></strong></p> <p>Chioma Odo, MS.</p> <p>Supervisory Professor: Charles Darkoh, Ph.D.</p> <p><strong>ABSTRACT</strong></p> <p>The incidence of <em>C. difficile</em> infections (CDI) has been …
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Phenotypic, Genotypic, and Pathogenic Evaluation of E. coli ST131 Clinical Isolates
Since their identification in 2008, E. coli ST131 isolates have become a major cause of cystitis and pyelonephritis. However, these strains are not known to encode different, or increased numbers of virulence factors compared to other sequence types of pathogenic E. coli. To date, no data in the …
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A Genotypic Comparison of Staphylococcus lugdunensis Clinical Isolates of Diverse Geographic Origin
… be mistaken for Staphylococcus aureus both clinically and phenotypically. To learn more about the persistence and spread of this organism, the epidemiological relatedness of fifty-one Staphylococcus lugdunensis isolates from various geographic regions was assessed using molecular typing …
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Quorum Signaling and Biofilm Antibiotic Resistance Phenotypes of Nontypeable Haemophilus influenzae Clinical Isolates
The genetically and phenotypically diverse bacterium nontypeable <i>Haemophilus influenzae</i> (NTHi) is a leading cause of otitis media (OM). This disease affects children around the world. Treatment is complicated by the ability of the bacteria to form biofilms in which they are more tolerant to …
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Outer Membrane Porin Regulation among Different Sequence Types of Escherichia coli Clinical Isolates
… that the regulation of porin production in clinical isolates of E. coli would involve sRNAs and be dependent upon sequence type, impacting the emergence of carbapenem resistance through levels of porin production. Four main findings resulted from testing this hypothesis. (1) Levels of ompC …
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Analysis of clnical features of cryptococcosis and antifungal susceptibility of clinical isolates in Korea
… and antifungal susceptibility. We analyzed clinical features of cryptococcosis and antifungal susceptiblity of clinical isolates. METHODS: We analyzed retrospetively 43 cases of cryptococcosis diagnosed in Ajou University hospital from 1995 to 2011. For antifungal susceptibility data, 78 …
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The determination and characterisation of beta lactam resistance in clinical isolates of Acinetobacter baumannII
Bibliography leaves 122-136.
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Cellular Dynamics and Disease Outcome of Type 3 Streptococcus pneumoniae Clinical Isolates Differ Between Strains
… was S. pneumoniae. To look further into these clinical isolates, we chose three different type 3 pneumococcal isolates and observed the immune cellular dynamics as well as capsule production, and saw that even with the same serotype immune responses can differ.
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Expression Pattern of Drug-Resistance Genes in Matched Clinical Isolates of Candida albicans at Variable Fluconazole Exposure Times
… in the ergosterol biosynthesis pathway. In some clinical isolates, resistance to FLC is due to overexpression of a) the encoding genes CDR1 and CDR2 for the ABC Transporters, b) the Major Facilitator Transporter encoding gene MDR1, or c) ERG11, the azole target gene. Previous studies have shown …
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A Cloning-Free Recyclable System for CRISPR-Cas9 Mediated Mutant and Reversion Construction in Candida albicans Clinical Isolates
… increasingly evident that genetic diversity in clinical isolates plays an important role in antifungal resistance, virulence, and pathogenicity. These recent discoveries highlight the need for genetic tools that are capable of investigating genes in multiple strain backgrounds. Here we build on …
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An analysis of the interaction of environmental and clinical isolates of Aspergillus fumigatus with vertebrate and invertebrate immune responses
… Assessment of the virulence of A. fumigatus isolates has previously centred on the use of murine models of aspergillosis however in recent years there has been an increasing body of evidence suggesting the use of invertebrates as a viable alternative. The work presented here sought to further …
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Assessment of motility and hemolytic activity in clinical isolates of Acinetobacter baumannii from University of Kentucky hospital, Lexington, KY
… the presence of these two virulent traits in clinical isolates. Forty-eight clinical isolates were recovered from University of Kentucky hospital in Lexington, KY. No hemolytic activity was observed for any of the isolates. Evidence of surface motility was observed in 13 isolates. The brand …
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The immunological role of cell wall components from diverse Mycobacterium tuberculosis clinical isolates in regulating HIV-1 replication in human macrophages
… This work investigated the hypothesis that clinical Mtb strains with single nucleotide polymorphisms (SNP) in lipid-metabolizing genes, required for cell wall lipid biosynthesis, differentially affect HIV-1 replication and human macrophage inflammatory response during Mtb-HIV-1 co-infection …
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Evaluation of Antibiotic Drug Synergisms Against Periodontal Aggregatibacter Actinomycetemcomitans
… over 20 years ago, and only involved subgingival clinical isolates of the organism from periodontitis patients in Europe. Since temporal and geographic changes in antimicrobial susceptibility are documented among periodontitis-associated microorganisms, it is not known whether or not antibiotic …
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Challenging the Paradigm of Clinical Triazole Resistance in Aspergillus fumigatus
… emergence of triazole resistance among both clinical and environmental isolates, and a large proportion of this resistance remains unexplained. In this work, we characterize the contributions of previously identified mechanisms of triazole resistance, including mutations in the …
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The genetic location and regulation of aminoglycoside resistance genes in acinetobacter
The genetic basis of aminoglycoside resistance in clinical isolates of Acinetobacter was investigated. The aadB genes cloned from two clinical isolates, strain CHA and strain SUN, were sequenced. Analysis of the sequencing data indicated that both genes were contained on gene cassettes, which had …
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Gliotoxin Production in Aspergillus fumigatus
… compared the amounts of gliotoxin produced from clinical and environmental isolates of A. fumigatus. We hypothesized that the amount of gliotoxin produced would be higher in the clinical isolates in comparison to the environmental isolates. Cell assay results showed that the clinical isolates …
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