Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 107 for “"Clinical evidence"”.
-
PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9, ATHEROSCLEROSIS AND EXTRACELLULAR VESICLES ¿ EXPERIMENTAL AND CLINICAL EVIDENCE
… The results of the present study provide evidence that PCSK9 plays an inflammatory role by means of EVs, at least by those derived from smooth muscle cells of vascular origin.
-
SMN DEFICIENCY INDUCES NEUROACTIVE AMINOACIDS DYSMETABOLISM: BRIDGING INSIGHTS FROM PRECLINICAL MODELS TO CLINICAL EVIDENCE IN SMA PATIENTS
… hallmark of SMA. By integrating cross-species evidence, they highlight amino acids as grounded therapeutic candidates for SMN-independent intervention. This work provides a translational framework for developing biomarker-guided combination strategies to improve long-term outcomes in SMA.
-
The evidence basis of diving and hyperbaric medicine - a synthesis of the high level clinical evidence with meta-analysis
… is that treatment is based on little or no good clinical evidence. Aims: The primary objective of this thesis is to make a useful response to that criticism. I planned to collate all the available randomised evidence in the fields of diving and hyperbaric medicine, supply a critical appraisal of …
-
The Enduring Outcomes of Stress During Neurodevelopment Dynamically Impact Food Reward Responsiveness and Valuation: A Meta-Analysis of Pre-Clinical Evidence
… reward-processing pathology in later life. Pre-clinical research using rodent models provide a means for examining the enduring effects of ELS on reward-related behaviours in a causal manner. Evidence from pre-clinical research varies; some studies suggest that ELS reduces behavioural indices of …
-
Βιβλιογραφική ανασκόπηση κλινικών μελετών που εξετάζουν το ρόλο της λιποπρωτεΐνης α (Lpa) στην καρδιαγγειακή νόσο / The role of lipoprotein (a) in cardiovascular disease: a literature review of clinical evidence
Τα αποτελέσματα της λιποπρωτεΐνης (α), (Lp(a), έχουν συσχετιστεί γενικότερα με αυτά της καρδιαγγειακής νόσου (CVD), μεταξύ των γενικών πληθυσμών. Ωστόσο, η σχέση μεταξύ των αποτελεσμάτων της Lp(a) και καρδιαγγειακού κινδύνου λόγω αθηρωμάτωσης (Atherosclerotic Cardiovascular Disease - ASCVD) σε …
-
The path from clinical evidence to use of drugs – Marketing analysis of factors influencing the market performance of drug therapies = A klinikai evidencia útja a gyógyszerhasználatig – A gyógyszerhatóanyag terápiák piaci teljesítményére ható tényezők marketing szemléletű elemzése
A gyógyszeripari kutatás eredményeként egy-egy kielégítetlen orvosi igényre többféle hatásmechanizmus és ezen csoportokon belül több hatóanyag születik válaszként. A gyógyszerkutatás marketing szempontból a hatásmechanizmusok szintjén valóban eltérő megoldásokat kínál az igények kielégítésére, míg …
-
Bioinformatics e Biostatistics applied to research in pediatric genetic disease. Clinical evidence in IFNλ4 polymorphisms associated with HCV infection in patients with beta thalassemia and WGCNA analysis weighted for IFNλ4 genotype rs12979860 to detect RPL9P18 as hub in HCV infected cell.
Genome-wide association studies have identified host genetic variation to be critical for spontaneous clearance and treatment response in patients infected with hepatitis C virus (HCV). We demonstrated the same in patients with thalassemia major infected by genotype 1b of HCV. In the present first …
-
COVID-19 Therapeutics – A landscape analysis using systematic reviews and clinical data
… conduct a critical evaluation of the scientific evidence and present the current landscape for COVID-19 therapeutics. We first discuss efforts to repurpose old drugs and to discover novel drugs against COVID-19. We then evaluate the clinical evidence of the most promising drug candidates that are …
-
Gastric haemorrhage in acute intracranial vascular accidents: submitted for the William Leslie Prize in Medicine
… and melaena in one ; in the seventh case no clinical evidence of bleeding was obtained, but blood was found in the stomach at autopsy.
-
The Management of acute lateral ankle sprains: A survey of South African Surgeons and best evidence available
… frequent injury in modern sports with increasing evidence that it is not as innocuous as previously thought. Conservative treatment options include various forms of immobilization such as casts, moonboots and stirrup braces, followed by a rehabilitation period involving different modalities. …
-
Arterial microanastomosis with size mismatch : a trial of two techniques
… an increasingly common finding. Experimental and clinical evidence confirms that patency rates decrease with increasing diameter mismatch, but no good evidence is available to direct the choice of end-to-end microanastomotic technique where a small-to-large discrepancy exists. A programme of …
-
Assessing The Potential Clinical Impact of Variable Biological Effectiveness In Proton Radiotherapy
… medium. This effect is currently quantified in clinical settings by assigning protons a relative biological effectiveness (RBE) value of 1.1 corresponding to 10% increased effectiveness compared to photon radiation. Numerous studies have shown, however, that the RBE value of protons is variable …
-
Herstellung und Charakterisierung von Taubenimmunglobulin Y-spezifischem Hyperimmunserum und Einsatz in der Pacheco-Serodiagnostik
… 18.8% (56/298) of psittacine patients without clinical evidence of Pacheco´s disease or history of contact to diseased birds were tested PsHV-antibody positive. In sera from birds clinical signs indicative for Pacheco´s disease PsHV-antibodies could be detected in 33.3% (10/30). Applied to …
-
A cost-utility and budget impact analysis of long-acting insulin analogues, (determir, glargine and degludec) for the treatment of adults with T1DM in South Africa
… sector context. Methods: A systematic search for clinical evidence was performed to inform the economic evaluation. A cost-utility analysis was carried out utilising Markov modelling. Seven comparators were modelled representing the various insulin types and treatment regimens. For each …
-
Cannabinoid CB1 Receptor Expression and Localization in the Dorsal Horn of Male and Female Human and Rat Spinal Cord Tissue
Preclinical and clinical evidence suggests that cannabis, a potent cannabinoid, has potential analgesic properties. However, there is a gap in the literature in respect to cannabinoid receptor expression and localization in the spinal cord across both sex and species, with almost nothing known in …
-
Risk factors associated with the exposure of neonates to acinetobacters through the ingestion of infant formula in NICUs
… combined with the multidrug resistance of the clinical isolates of this organism poses a real threat to neonates. The understanding of its pathogenicity is still at an elementary stage despite the clinical evidence of nosocomial infections, and the concern of the FAOWHO (2006) regarding …
-
Modeling zero-inflated and overdispersed count data: application to in-hospital mortality data
… ill patients in the intensive care unit (ICU). Clinical evidence shows that hyperchloremia is associated with increased in-hospital mortality. Length of hospital stay (LOS) is often used as an indicator of hospital efficiency, a proxy of resource consumption and is especially important in …
-
Evidence-based claims adjudication: a technology-based learning tool for automobile insurance claims adjusters
My thesis aimed to 1) develop an evidence-based claims adjudication framework for automobile insurance claims adjusters; 2) develop a technology-based learning (TBL) tool to train Aviva Canada claims adjusters about evidence-based claims adjudication and the evidence-based management of neck pain; …
-
THE ASSESSMENT AND DEVELOPMENT OF FOLLISTATIN AS A GENE THERAPY AND ITS POTENTIAL ORTHOPEDIC APPLICATIONS
… patients. However, there is substantial clinical evidence that the upregulation of follistatin results in better muscle growth and strengthening. Moreover, the use of adeno-associated viruses ensures the efficient, specific delivery of the transgenes to the muscle that requires it. …
Page 1 of 6