Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 60 for “"Clinical diagnostics"”.
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Natural language processing for precision clinical diagnostics and treatment
… application of natural language processing to clinical diagnostics and treatment within the palliative care and serious illness field. I explore a variety of natural language processing methods, including deep learning, rule-based, and classic machine learning, and applied to the identication …
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Applications, complexities, and opportunities of metagenomics for clinical diagnostics and viral discovery
… detection of microbial nucleic acids from clinical and environmental samples. However, despite its growing adoption in diagnostic and surveillance settings, substantial variability in analytical workflows and interpretive criteria continues to limit reproducibility and clinical …
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Multiplexed protein biomarker analysis on silicon photonic microring resonators: translation towards clinical diagnostics
… indicators of human physiological states. In clinical practice, they play a strong role in presymptomatic diagnosis of various diseases, as well as evaluation of disease prognosis and aid in treatment decisions making. Due to the importance of biomarkers, much efforts were made towards the …
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Data analysis in respiratory medicine : model selection and classification methods applied to clinical diagnostics
… of <br>data analysis for the advancement of clinical diagnostics in respiratory <br>medicine. <br> <br>Part I first exposes the clinical problem of incomplete forced expiration manoeuvres, an inconvenience that frequently arises when the lung function of patients with impaired respiration is …
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3D printing in Clinical Diagnostics: A Versatile Tool to Develop Testing Devices for the Diagnosis of Infectious Diseases
… on the use of early 3D printed parts to support clinical trials or early commercialization while the final design is still being optimized. This relationship was crucial in support of enhanced health care and general emergency response, as shown during the COVID-19 pandemic. A few examples where …
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Hierarchical selective electrokinetic concentration : the universal next-generation biomolecule enrichment technique for molecular diagnostics
… in complex biological media may greatly advance clinical diagnostics and biotechnology development. Because of the slow mass transport and weak binding kinetics at ultralow concentration of target biomolecules, enrichment of target biomolecules plays an essential role in the detection of …
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Microfluidic and electronic detection of protein biomarkers
… Thus, protein testing is widely utilized in clinical diagnostics. The current workflow for protein testing involves the processing of patient samples that are collected at healthcare facilities. These samples are sent to centralized laboratories and analyzed using sophisticated instruments. …
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Integrated optical fluorescence multi-sensor system
… of water or food samples. Other areas, such as clinical diagnostics or forensic science also have a demand for highly multiplexed analytical systems. This thesis presents a novel 32-analyte integrated optical fluorescence-based multisensor, and its integration to an automated multi-bio-sensing …
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A General Purpose Programmable Microfluidic Platform for Screening and Optimization of Biological Assays
… is a fundamental process in today’s medicine and clinical diagnostics, comprising of several processes ranging from finding new target molecules having the desired therapeutic potential to identifying biomarkers for accurate diagnosis of a spectrum of diseases. Current high throughput screening …
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Nové diagnostické metody v dermatologii: neinvazivní diagnostika nemelanomových nádorů kůže
… understand of NMSC development and to help the clinical diagnostics. Some of the new technologies, especially the high frequency ultrasonography described in the paper have the potential to be used in the daily praxis of NMSC diagnostic. The fluorescence diagnostic brings in our point of view a …
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The Johnson and Johnson journey deploying SmartOps for multi-echelon inventory optimization
… in Johnson and Johnson's Medical Devices and Diagnostics supply chain. The basis for this thesis is an internship project that focused on implementing SmartOps in the Transfusion Medicine and Mainframe Slides businesses within Ortho Clinical Diagnostics, a group within the Medical Devices and …
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Gene expression profiling approach towards enhancement of malaria vaccine development
… (RNASeq) applied to samples collected during clinical trials performed at the CAUCASECO research center in Cali, Colombia. In each case, peripheral blood samples from volunteers and patients enrolled in studies addressing different aspects of immunity against P. vivax malaria were studied, …
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Comparing diene derivatisation methods of dry blood spot samples for vitamin D metabolites quantification by liquid chromatography-tandem mass spectrometry
… a brief introduction of the routinely used clinical diagnostics assay enzyme-linked immunosorbent assay (ELISA) as a reference method and is compared to an LC-MS/MS assay, to ascertain discrepancies and agreement between both methodologies from the same volunteer samples. Chapters 3 and 4 …
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Elastic-anisotropic properties of the porcine superflexor tendon measured by instrumented indentation
… because of the potential for indentation-based clinical diagnostics. Shortage of previous research relating to instrumented indentation of soft tissue in the kPa range, such as tendon, motivated a protocol development phase in our study. Once indents in tendon were repeatedly successful and the …
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CRISPR-integrated Biosensors for Human Health: Novel strategies for pathogen detection and cancer screening
… essential for improving public health, guiding clinical decisions, and ensuring food safety. CRISPR-based biosensors offer a promising solution due to their programmability, sensitivity, and versatility. This dissertation focuses on the development of CRISPR-integrated biosensing platforms for …
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Study and achievement of organic-inorganic innovative materials through electrochemical techniques
… suitable as materials in sensors, biosensors, clinical diagnostics, biological sensing and energy storage and conversion. In this context, to obtain a stable, durable bond with the surface and controllable process, the electroreduction of aryldiazonium salts is a promising alternative to …
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Taste physiological mechanisms and their health implications, analyzed by genetic, epigenetic, and artificial intelligence analyses
… perspectives for personalized nutrition, clinical diagnostics, and therapeutic applications.
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Wearable Lab and BioFab on body : towards closed-loop bio-digital human augmentation
… usually performed in the laboratory for clinical diagnostics and analysis of human health. To illustrate our vision of having a lab on body, we prototyped "Wearable Lab" a bio-digital platform for sensing biochemical and digital data from saliva. Our platform contains digital sensors such …
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Morphological alterations in frontotemporal dementia:
… dementia (FTD). With the aim to improve the clinical diagnostics of FTD, we explored the diagnostic potential of measuring morphological alterations in the white matter by diffusion tensor imaging (DTI)- MRI, compared with the more commonly used assessment of grey matter thickness and volume. …
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Development of a sensitive diagnostic multiplex platform based on digitally encoded microcarriers
… need in biomolecular research and clinical diagnostics to carry out many assays simultaneously in on tube, several microcarrier-based multiplex technologies (suspension arrays) have arisen in the past few years. Simultaneous detection of different target molecules that are present …
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