Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 268 for “"Clinical Utility"”.
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The clinical utility of multidisciplinary rehabilitation in individuals with Huntington’s Disease
… to underlie the onset and progression of many clinical features of HD. Despite scientific progress, there is still no cure or disease modifying therapy for HD, and available pharmaceutical agents only provide partial relief of motor and psychiatric features. An emerging body of evidence …
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MMPI-2-RF : clinical utility with a traumatic brain injury population
… factors. Therefore, this study examined the clinical utility of the shortened 338-item MMPI-2-RF inventory with a post-acute TBI population as a practical alternative. The MMPI-2-RF requires a fifth-grade reading level and takes 35-50 minutes to administer. The MMPI-2-RF also includes revised …
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Clinical Utility of Advanced Neuroimaging Techniques in the Presurgical Assessment of Patients with Epilepsy
… significant challenge. This study evaluates the clinical utility of three neuroimaging techniques in the pre-surgical assessment at the newly designated District Epilepsy Center, Kingston Health Sciences Center. Additionally, language lateralization indices (LI) are compared when processed …
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Mutational Landscape of Noncoding Ultraconserved Elements in Human Cancers: Functional Relevance and Clinical Utility
… DNA regions (ncUCEs), and their functional and clinical relevance in cancers remain poorly characterized. In this thesis, we perform a systematic analysis of whole-genome sequencing (WGS) data from the International Cancer Genome Consortium (ICGC) and in-house targeted sequencing of 13,736 UCEs …
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Analytical validation and clinical utility of a canine hemoglobin A1c point-of-care assay
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2024-09-16 without embargo terms
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Investigating the Mechanisms and Kinetics of Circulating Tumour DNA Release to Improve its Clinical Utility
… with distinct subtypes, molecular features and clinical behaviours. Significant advances to better define this heterogeneity have revealed new targets and attempted to stratify patients into clinically meaningful groups. Human papillomavirus (HPV)-positive HNSCC has been recognized as a distinct …
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Clinical Utility and Impact of Targeted Nucleic Acid Sequencing in Myeloid Malignancies and Precursor Lesions
… leukemia (AML), with expanding diagnostic and clinical significance. Given the breadth of genetic aberrations required to diagnose these diseases, higher throughput testing is necessary. Targeted next-generation sequencing (NGS) panels offer promise in detecting these molecular features. …
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Investigation of C-Reactive Protein and Leptin as Biomarkers of Obesity with Potential Clinical Utility
<p>Obesity and its subsequent disease states are major health problems in the United States. In many ways, obesity can be considered a “disease state” itself due to the changes it causes on the body. High-intensity exercise also places acute stress the body, putting humans in recovery from exercise …
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Clinical utility of B-type natriuretic peptide (NP) in paediatric cardiac surgery: a systematic review
… use in several patient populations and clinical situations. It is a hormone secreted primarily by ventricular myocytes in response in myocyte stretch or ischaemia.
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Clinical utility of the Wechsler Scales in psychological evaluations to estimate vocational aptitude among learning disabled young adults
… exploration of options. This study examines the utility of traditionally available psychometric data in assisting the clinician make initial, exploratory estimates of vocational aptitude without referring the client for specialized testing. Wechsler Adult Intelligence Scale - Revised [WAIS-R], …
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Brief Adjustment Scale - 6 for Measurement-Based Care: Further Evaluation of Psychometric Properties, Ethnic Samples, and Clinical Utility
… psychometric properties of the BASE-6 in both clinical and nonclinical populations. More specifically, psychometric properties including reliability and validity, generalizability for different race/ethnic samples, and clinical utility within the context of MBC were examined. Three adult …
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Clinical utility of serum amyloid A to differentiate feline disease processes using a newly validated point of care assay
DSpace SAF Submission Ingestion Package generated from Vireo submission #17965 on 2022-11-14 at 17:34:07
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Clinical utility of 3D power doppler ultrasound and maternal biomarkers in the prediction of pre-eclampsia in high-risk pregnancies
… high-risk women.<br/><br/>To determine the added clinical utility and predictive value of these biophysical and biochemical parameters, a prospective longitudinal observational study of high-risk women and low-risk control participants was carried out (PREDICT). Set within the context of a …
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Identification of biomarkers with clinical utility in liquid and tissue biopsies of patients with head and neck squamous cell carcinomas
Los carcinomas escamosos de cabeza y cuello (CECC) comprenden un complejo y heterogéneo grupo de neoplasias que, a su vez, presentan una amplia diversidad de alteraciones genéticas y moleculares. Sin embargo, dichas características ofrecen grandes oportunidades para identificar potenciales …
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Investigation into the elements contributing to the constructs of sense of coherence and hardiness with particular reference to clinical utility
… by the psychological community and used in both clinical and occupational settings. Despite their wide appeal however, there appear to be considerable questions surrounding their validity.<br/><br/>The validity and clinical utility of these 2 questionnaires was examined in relation to personality …
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Investigation of the Clinical Utility of the Spatio-Spectral Dynamics of Sensorimotor ECoG in Response to Different Somatosensory Stimulation Modalities in Human Subjects
… Electrical Stimulation (DCS) is also used in clinical practice for cortical mapping, which might elicit seizures. We hypothesized that automated mapping of the sensorimotor cortex could be achieved with high-density electrocorticogram (ECoG) grids. The recorded neural data interpretation can …
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The clinical utility of tissue polymerase chain reaction, tissue culture, and tissue histology in blood-culture negative infective endocarditis - a South African single hospital experience
… may identify the causative agents, guide further clinical management and improve local IE-related epidemiological data. The clinical utility of additional analysis of explanted tissue in a local South African setting has yet to be described. Objectives. This study aims to assess the clinical …
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