Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Clinical Trials [methods]"”.
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A Psychosocial Approach to Understanding Causality Assessment in Early Phase Oncology Clinical Trials: A Phenomenological Study
… causality assessment in early phase oncology clinical trials? Methods: Thirty-two qualitative interviews were explicated with the aid of “Naturalistic Decision Making”. Data explication consisted of phenomenological reduction, delineating and clustering meaning units, forming themes, and …
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The effect of patient warming on perioperative cardiovascular outcomes in interventional clinical trials: A systematic review and meta-analysis
… on perioperative cardiovascular outcomes in clinical trials. METHODS: A systematic review with meta-analyses was conducted. Six data bases were searched from inception until 5th July 2021 for studies that prospectively assigned participants to any physical warming strategy and reported on …
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Benchmarking and Implementation of A New Independent Monte Carlo Dose Calculation Quality Assurance Audit to ol For Clinical Trials
… in the National Cancer Institute sponsored clinical trials administer radiation in doses that are clinically comparable to those of other participating institutions. To complement the effort of the RPC, an independent dose calculation tool needs to be developed that will enable a generic …
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Statistical analysis of end-points in cancer clinical trials
The major end-points arising from cancer clinical trials are reviewed. These are: tumour response, treatment morbidity, survival with related data, and quality of life. A survey of tumour response data from 81 published clinical trials found the most common statistical test in use to be a Chi …
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Population pharmacokinetic modelling for dose optimization of esomeprazole to treat early-onset preeclampsia
… Esomeprazole is a proton pump inhibitor with preclinical efficacy data showing it lowers concentrations of soluble fms like tyrosine kinase 1 (sFlt-1) and soluble endoglin (sEng), pathognomonic biomarkers identified in preeclampsia. A randomized controlled trial, Preeclampsia Intervention with …
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Towards a blood-based biomarker for remyelination: Glial cell death and associated byproducts in demyelinating disease
… patients. In both MS and PML, there is a clinical need for relevant fluid biomarkers to predict/monitor disease progression and to assess treatment response, including for novel therapies targeting myelin repair. While several potential remyelinating agents have proceeded to clinical …