Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 686 for “"Clinical Trial"”.
-
Bayesian Adaptive Clinical Trial Design
… chemotherapeutic agents, making the conventional trial design paradigm inefficient and dysfunctional. Specifically, the focus of dose-finding trials has shifted from finding the maximum tolerated dose (MTD) to the optimal biological dose (OBD), defined as the dose that optimizes the risk–benefit …
-
Challenges facing clinical trial design in oncology
Background: Clinical trials are designed to help patients to live better and/or longer. Each component considered in the design of the trial has the potential to shape and impact the ultimate result. Interpretation of a trial as positive or negative hinges on the endpoint of interest and the trial …
-
Packaging Design for Remote Clinical Trial Operations
As remote clinical trials continue to revolutionize the old-fashioned clinical trials model and increase patient enrollment, it has become apparent that there is no regulatory framework in place to standardize their utilization. In traditional clinical studies, there is very little independent user …
-
Clinical Trial Enrollment In A Multidisciplinary Prostate Cancer
<p> <p>Purpose: Clinical oncology trials are hampered by low accrual rates. Less than 5% of adult cancer patients are treated on a clinical trial. We aimed to evaluate clinical trial enrollment in our Multidisciplinary Prostate Cancer Clinic and to assess if a clinical trial initiative, introduced …
-
Generating Medical Logic Modules for Clinical Trial Eligibility
Clinical trials are important to the advancement of medical science. They provide the experimental and statistical basis needed to determine the benefit of diagnostic and therapeutic agents and procedures. The more patients enrolled in a clinical trial, the more confidence we can have in the …
-
Predicting Patient Outcomes in the EPOCH Clinical Trial
… (TARE) can improve patient outcomes. The EPOCHclinical trial demonstrated that TARE improved hepatic progressionfree survival (hPFS) in patients with colorectal liver metastases, and computational methods to analyze the multimodal data collected can identify patient subgroups and predict …
-
Novel Bayesian Adaptive Clinical Trial Designs In Early Phases
<p>Early phase, or phase I and phase II, trials are the first step in testing new medicines that have been developed in the lab. The main goal of phase I clinical trials is to establish the recommended dose of new drugs for phase II trials. For the cytotoxic drugs, the goal is to find maximum …
-
Estimation of clinical trial success rates and related parameters
… Using a sample of 185,994 unique entries of clinical-trial data for over 21,143 compounds from January 1st, 2000 to October 31st, 2015, we estimate aggregate success rates and durations of clinical trials. We also compute disaggregated estimates by stratifying across several features …
-
Modeling correlations in clinical trial outcomes using machine learning
… the problem of characterizing the covariance of clinical trial outcomes using drug and trial features. The binary nature of FDA approvals makes drug development risky, but approaches in finance theory could better manage that risk, allowing more high potential drugs to be developed. To apply …
-
A data driven semantic framework for clinical trial eligibility criteria
… matching of potential subjects with appropriate clinical trials. Eligibility criteria for clinical trials are typically specified in free text as inclusion and exclusion criteria for each study. While this is sufficient for a human to guide a recruitment interview, it cannot be reliably parsed to …
-
Influence of clinical research investigator fraud on clinical trial participation
<p>The number of clinical research investigators whom the Food and Drug Administration (FDA) has disqualified or totally restricted has been increasing since 1964. In addition, several public polls and surveys indicate a major dilemma in clinical trial participation and public perceptions of …
-
Deep learning methods for clinical trial design, execution, and analysis
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2025-10-19 without embargo terms
-
Aligning synthetic clinical trial data with human-preferred clinical endpoints
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2026-12-01
-
A clinical trial of TrenDx : an automated trend-detection program
Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 1996.
-
DIFFERENT TECHNIQUES FOR DENTAL IMPLANTS SITE PREPARATION: A CONTROLLED CLINICAL TRIAL
… (Step drilling sequence) could modify the clinical and/or patient-centered variables We included and treated 60 subjects, for a total of 86 implants. We found no evidence of a difference in bone resorption, which increased significantly over time, between the two groups. Regarding the …
-
Behavioural Activation for Depression: a systematic review and controlled clinical trial
… recommended. Promising results from randomised trials has renewed interest in behavioural therapy, which may be suitable for delivery by non-specialist therapists. Aims To deliver a phased research programme to examine the clinical and cost effectiveness of behavioural therapy for depressed …
-
Analysis of clustered competing risks with application to a multicentre clinical trial
… instance, in registry cohorts or multi-centre clinical trials. The Fine and Gray model has been extended to the analysis of clustered time-to-event data, by including random-centre effects or frailties in the sub-distribution hazard. This research focuses on the analysis of clustered competing …
-
Innovative Alzheimer's disease clinical trial design in the coming age of biomarkers
… drugs in recent years, the length of AD clinical trials has tripled and the enrollment has gone up drastically. These investigational disease-modifying drugs address new targets including the amyloid beta and tau protein aggregation pathways in the brain. They have opened up a whole …
-
Remote Clinical Trial Operations: Patient Education for Medical and Wearable Device Use
… healthcare, including enabling remote clinical trials. Yet, there is no regulatory framework in place to standardize their utilization. In traditional clinical studies, user-related error is minimized, as a designated clinician performs all physiological measurements on each subject. …
Page 1 of 35