Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 51 for “"Clinical Testing"”.
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Design, Validation, and Clinical Testing of a Novel Fastening Device for a Scoliosis Brace
… were: Controlled Tension Units (CTU), Robotic Testing Platform. The methods were as follows: The controlled tension units were mounted in a robotic testing platform that was programmed to displace the CTU device at a set speed (or rate of spring displacement) and measure the force response of …
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The performance of cross-linked acellular arterial scaffolds as vascular grafts; pre-clinical testing in direct and isolation loop circulatory models
There is a significant need for small diameter vascular grafts to be used in peripheral vascular surgery; however autologous grafts are not always available, synthetic grafts perform poorly and allografts and xenografts degenerate, dilate and calcify after implantation. We hypothesized that …
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Signal identification for visual electrophysiological recordings. A comparison of signal analysis techniques and their application to clinical electrophysiology of vision.
… signals and can they be applied to improve clinical testing and analysis? Methods: Automated signal identification algorithms were applied to multifocal electroretinogram (mfERG) and visual evoked potential (VEP) recordings. To simulate the types of signal identification problems encountered …
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Surveillance of SARS-CoV-2: From Sewage to the Clinic
… wastewater largely paralleled local increases in clinical cases of COVID-19. These studies highlight the potential of wastewater surveillance to provide early warning of emerging outbreaks – as well as the need for improved modeling and quantitation to understand the relationship between viral …
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Objective Measurement of Peripheral Edema as Symptomatic of Congestive Heart Failure
… tissue properties. Additionally through clinical testing, we identified improvement opportunities to the device design to make it more user friendly.
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The facial inversion effect throughout healthy adult aging : an event-related brain potential study
… research, along with other neuroimaging and clinical testing, has shown that it is possible to detect subtle changes to the central nervous system before the onset of behavioral changes due to dementia. In this research, a sequential imaging oddball paradigm that utilizes upright and inverted …
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InterNAV2.0: Minimally Invasive Robot-Assisted Tumour Ablative Therapies
… as a navigation and control environment for clinical use. The objective of the research described in this thesis is to make significant enhancements and add new features to InterNAV1.0 in order to obtain a fairly general navi gation and control environment suitable for use in animal and …
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Spatial and Temporal Analysis of SARS-CoV-2 in Sewer Network in Reno-Sparks Metropolitan Area
… faced unprecedented challenges in implementing clinical testing to monitor and inform public on the spread of the disease. In the early stages of the pandemic, researchers indicted that the virus is present in wastewater and infected individuals shed the genetic material of SARS-CoV-2 virus in …
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Magnetostatic Modeling for Microfluidic Device Design
… prior to in vitro experimentation, animal testing, and finally clinical testing. To better understand and unleash this technology, COMSOL®, which is a finite element analysis and multiphysics simulation software, has recently been used to model superparamagnetic particles in several …
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Paravalvular sealing pf percutaneous heart valves
… valve replacements (TAVR) can lead to adverse clinical consequences and has been shown to correlate to an increased late mortality and morbidity. Quantification, graduation and testing for PVR has proven challenging and a standardized method for pre-clinical testing is still sought. Commercial …
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Exploring the role of damping in a passive prosthetic knee through modeling, design, and testing
… of dampers was evaluated through field and clinical testing with unilateral transfemoral amputees. The results of the studies showed that not only damping is required to prevent hyper flexion, but the optimal damping range allows achieve a peak knee flexion close to able-bodied. In future …
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Clinically relevant magnetic resonance imaging and spectroscopic imaging development
… SAR considerations, parameter adjustments and clinical testing. The method can deliver 3D Tl or T2 weighted brain image with isotropic Imm3 voxel resolution in approximately 10 minutes. The ability to obtain high spatial resolution in reasonable time periods has wide clinical applications such …
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A novel genomic approach to multiple cancer diagnostics using mutations in blood bound EV RNA: Machine Learning Methods For Biomarker Detection and Protein Mutation Assessment
… counts across genes and samples to offer clinical insight. In an attempt to analyse the complexity of EV RNA mutations on downstream proteins, machine learning was used to develop models capable of assessing the severity of a single amino acid mutation within a protein sequence. Multiple …
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Improving the efficiency of the later stages of the drug development process : survey results from the industry, academia, and the FDA
… pathway includes basic scientific discovery, pre-clinical testing in animals, clinical development in humans, and an application process. The Food and Drug Administration is responsible for the oversight and approval of drugs going through this process. Numerous financial and economic studies have …
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Antifouling and Antithrombogenic Ultrathin Surface Chemistry for Bioanalytical and Biomedical Applications
… acoustic sensor (EMPAS) system - as potential clinical assay alternatives to current screening/diagnostic tests. Biosensing platforms featured dual-functional, binary organosilane surface chemistry on quartz combining high analyte binding capability (for biorecognition) with pronounced …
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Silencing mutant Huntingtin by RNA interference for the treatment of Huntington Disease
… HD mouse models enables focused therapeutic testing to develop potential treatments for HD. RNA interference (RNAi) therapy is a targeted gene silencing approach whereby synthetic RNA constructs are shuttled into the cell by viral vectors and used by the cell’s endogenous RNAi machinery to …
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Identification and Characterization of Potential Novel Targets in Thyroid Carcinoma: Evidence of Non-Oncogene Addiction Unveiling Tumor Cell Vulnerabilities
… a poor prognosis. Target therapies introduced in clinical testing are often unsuccessful; therefore, novel therapeutic strategies are needed. To identify critical nodal points for therapeutic intervention, our laboratory faced the “non-oncogene addiction” (NOA) paradigm, which asserts that the …
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Reproducibility of a continuous-wave Doppler ultrasound system for assessment of ascending aortic blood flow responses during graded exercise testing with healthy individuals
… is modest day-to-day response stability for clinical testing with the Doppler parameter of PkV. Reliability/stability was best in exercise stages which encompass the speed and grade range of 45.0 m•min⁻¹/10%. - 111.7 m•min⁻¹/14%, i.e., those in which all subjects can walk.
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Development, Implementation and Normalization of SARS-CoV-2 Wastewater and Environmental Monitoring
… epidemiological tool, capable of complementing clinical testing and offering community-level data to better inform public health strategies. The COVID-19 pandemic exposed significant gaps in public health surveillance, emphasizing the need for tools that could monitor SARS-CoV-2 viral spread in …
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Multispectral optical imaging for the detection and delineation of oral neoplasia
… work focuses on the design, construction, and clinical testing of a novel multispectral widefield optical imaging device for objective screening and delineation of oral neoplasia. The Multispectral Digital Microscope (MDM) acquires in vivo images of oral tissue in autofluorescence, narrow band …
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