Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Clinical Sciences and Immunology"”.
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The Role of IL-4 Receptor Alpha signalling on Foxp3 T Regulatory cells in Listeriosis and Tuberculosis
… of self-tolerance, immune homeostasis and regulation of the immune system. Cytokine signalling is a dominant component of environmental signals which controls the function of Forkhead box P3 (Foxp3) regulatory T cells. This thesis addressed the hypothesis that interleukin-4 receptor …
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Astrocyte-mediated immune modulation during mycobacterial infection
… system tuberculosis (CNS-TB) is the severest clinical extra-pulmonary manifestation of tuberculosis (TB) disease and constitutes approximately 1% of global cases. Little is known about the cells that regulate immune responses during CNS-TB infection. Microglia are the prime resident …
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Protein Kinase C - delta (PKC-δ): a critical hub for immunomodulatory functions in macrophages during Mycobacterium tuberculosis infection
Tuberculosis (TB) has reached epidemic levels and emerged as the second deadliest infectious disease globally after CoVID-19. By evolving the ability to evade host defense via intrinsic mechanisms, Mycobacterium tuberculosis (Mtb), the etiological agent of TB has been deleterious to human health …
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Effects of hormonal contraceptives on the female genital tract microbiota in South African adolescents
… Africa are disproportionally affected by HIV and often rely on injectable hormonal contraception (HC) to prevent unintended pregnancies. However, HC might affect HIV-1 risk through changes in the female genital tract (FGT) microbiota. We examined the impact of three different HC methods on the …