Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 10 of 10 for “"Clinical Science and Immunology"”.
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Bystander influence of nematode exposure on subsequent herpesvirus infections in vivo
… to promote host control of the infection and also parasite survival in the host. Helminth infections classically induce a potent Th2-biased and regulatory immune imprint. This immune response also influences unrelated inflammatory processes in the host. Studies have shown helminth …
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The role of Interleukin-4 induced gene 1 (IL-4i1) in allergic asthma and atopic dermatitis
… known as allergens. Both allergic asthma and atopic dermatitis (AD) are said to be induced by elevated levels of immunoglobulin E (IgE) and T helper 2 (Th2) immune cells and inflammatory associated cells such as eosinophils, mast, and basophils. Globally, asthma is affecting more than 300 …
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Development of an Autologous Human Dendritic Cell Vaccine against Mycobacterium tuberculosis in Patients with Extensively Drug-Resistant Tuberculosis
… drug-resistant tuberculosis (XDR-TB), and resistance beyond XDR-TB (often untreatable), is an increasing public health concern globally. Drug resistance has outpaced the drug development pipeline. Therefore, alternative immunotherapeutic approaches are urgently needed. In this …
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The characterisation of dendritic cell, microglial, macrophage and T cell responses during mycobacterial infection of the central nervous system
… (TB) remains a global health challenge and a quarter of the global population is infected with latent TB. It is a single infection that causes most deaths and was the number one cause of death in South Africa in 2017. Bacille Calmette-Guerin (BCG) remains the only licensed vaccine for …
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The role of Cysteinyl leukotriene type 1 receptor (CysLTR1) during Listeria monocytogenes infection in mice
… (LM). LM can infect both phagocytic and non-phagocytic cell types and induces its uptake by expressing internalin A and B, then secretes listeriolysin O (LLO), a virulence factor forming pores on the phagosome membrane to escape into the cytosol. Macrophages can phagocytose invading …
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Remodelling of Mycobacterial Peptidoglycan During Cell Division and the Epigenetics of Macrophages during M. tuberculosis infection
… infection with immunological consequences and as such, changes in PG structure are expected to have important implications on disease progression and host responses. Mycobacterial amidases have been shown to have important roles in the remodelling of PG during cell division in M. smegmatis …
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The association between the oral and vaginal microbiome of young South African women
Bacterial vaginosis (BV) and periodontal disease (PD) are conditions characterised by reduction of healthy bacterial communities in the vaginal and oral microbiomes respectively. Both BV and PD are associated with an increased risk of preterm labour and negative birth outcomes, yet it is unknown …
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The role of platelets in the pathogenesis of and immunity to helminth infections
… small, anucleate cells which circulate in blood and are often the first to respond to tissue damage and vascular inflammation caused by pathogens. Here they not only maintain tissue integrity and prevent bleeding, but also initiate and regulate a vast variety of immunologic responses. Little is …
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The role of Cysteinyl leukotriene receptor-1 during experimental helminth infections in murine model
… cysteinyl leukotriene receptor-1 (cysLTR1) and have been reported to drive Th2 immune responses. Initiation and amplification of robust Th2 immune responses is crucial for conferring protective immunity to helminth (Schistosoma mansoni and Nippostrongylus brasiliensis) infection in mice. The …
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The role of Surfacant Protein D in the control of human helminth infections
… D (SP-D) is essential for both homeostasis and as an innate immune opsonin. In the project presented here, we aimed to translate data recently published by our group, which demonstrated that SP-D contributes to protection against murine parasitic nematode infections, to human work. In the …