Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 134 for “"Clinical Pharmacology"”.
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The Clinical Pharmacology of Acetaminophen in Adult Horses
… treated with traditional NSAIDs, there is clinical need for safe, and effective anti-inflammatories and anti-pyretics for administration in these patients. The studies presented in this dissertation explore the pharmacokinetics, efficacy, and safety of acetaminophen in adult horses for use …
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Clinical Pharmacology of MS-275, A Histone Deacetylase Inhibitor
… longer half-life in humans compared to pre-clinical species. PK/PD analysis showed significant correlation between occurrence of DLT and higher systemic exposures. Although there was an increase in the acetylation of histone H3 and H4 over time, preliminary analysis showed no significant …
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Clinical pharmacology of camptothecins: Model based population pharmacokinetic and pharmacodynamic analysis.
Clinical pharmacology of camptothecins: Model based population pharmacokinetic and pharmacodynamic analysis.
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Chirality in clinical pharmacology : studies with ketoprofen / by Peter John Hayball.
Examines aspects of the potential enantioselective pharmacokinetics and pharmacodynamics of ketoprofen in humans, and develops methods for quantifying total (bound plus unbound) and unbound ketoprofen enantiomers in plasma.
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Introducing clinical pharmacology to hepatitis C therapy. Lessons learned from studies on therapeutic drug monitoring and drug-drug interactions
Contains fulltext : 142579.pdf (Publisher’s version ) (Open Access)
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Facilitating Pharmacogenetic Association Studies Using an Extensible Genotype Information Management System
… application in use by the Division of Clinical Pharmacology at Indiana University School of Medicine.
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Lipid sensitivity of the GPR132 receptor
… by the International Union of Basic and Clinical Pharmacology (IUPHAR) as an orphan GPCR, although there have been several reports linking it to activation by lipid molecules.<br/><br/>GPR132 has been linked to the pathologies of inflammation, nociception and cancer. Therefore, an …
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Investigating the Anti-Melanoma Activity of Combinatorial Paclitaxel and MEK Inhibitor
… to α-MSH-SPIONs that can wide the horizons of clinical pharmacology field.
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Determination of total, unbound, and intracellular concentrations of the antiretroviral drugs Efavirenz, Lopinavir, and Ritonavir
… Institute of Allergy and Infectious Diseases' Clinical Pharmacology Quality Assurance group for review and have been approved for use on clinical samples. A proof-of-concept correlation study of intracellular, unbound, and total drug concentrations is described using blood samples from six …
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Application of Advanced Bioanalytical Techniques to Studies of Oxaliplatin Chemotherapy
… for cellular uptake. In an analysis of a clinical pharmacokinetic dataset, linear equations were established for estimating area-under-the-plasma-concentration-versus-time-curve (AUC) from end-of-infusion plasma concentrations of intact oxaliplatin (AUC = 2.231*end-ofinfusion plasma …
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A pharmacometric approach to optimal use of second line drugs for multidrug-resistant tuberculosis
… efficacy and toxicity in MDR-TB. My PhD used clinical pharmacology approaches to improve the understanding of drug exposures, toxicity, and exposure-toxicity relationships during the first 12 weeks of MDR-TB therapy. Aims and methods 1. Using non-compartmental analyses, describe the …
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Subcellular Fractionation Methods for the Quantification of Endogenous Protein in Human Liver Using Targeted Proteomics
… support for expression-activity correlations in clinical pharmacology studies. Different from traditional xenobiotic bioanalysis, human endogenous protein quantifications using targeted proteomics face many challenges, such as high interference from matrix background and the low abundance of …
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Multimodal textbook design : analyzing the construction of the discourses of pharmacology
… study originates from a disagreement over which Pharmacology textbook fourth year medical students should use. The founding argument is that a Pharmacology textbook can be seen as constructing the discourses of the 'prescribing physician' As such, it simultaneously constructs and bears imprints …
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Propoxyphene, Norpropoxyphene, and Proadifen (SKF-525A) Are Mechanism Based Inhibitors of CYP3A4, CYP3A5, and CYP3A in Human Liver Microsomes
The purpose of this study is to determine if propoxyphene and norpropoxyphene are mechanism-based (irreversible) inhibitors of CYP3A, and to determine if propoxyphene and norpropoxyphene are reversible inhibitors of CYP3A. Mechanismbased inhibition is a type of irreversible inhibition that results …
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Population pharmacokinetic modelling for dose optimization of esomeprazole to treat early-onset preeclampsia
… Esomeprazole is a proton pump inhibitor with preclinical efficacy data showing it lowers concentrations of soluble fms like tyrosine kinase 1 (sFlt-1) and soluble endoglin (sEng), pathognomonic biomarkers identified in preeclampsia. A randomized controlled trial, Preeclampsia Intervention with …
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A mixed method study of the factors influencing the validity of medical and medication histories obtained from potential healthy adult clinical trial participants
… and can give a reasonable response. In clinical trials, obtaining an accurate medical and treatment history is also an important factor in establishing whether or not a person is an eligible participant, and thereafter supports the assessment of any change in health during the trial, for …
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Population pharmacokinetic and pharmacodynamic modelling to improve tuberculosis treatment
Tuberculosis continues to claim millions of lives each year despite enormous efforts to control the epidemic over the past century. It remains the leading cause of death worldwide from a curable infectious disease. Tuberculosis is a significant cause of maternal mortality and morbidity, but little …
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Comparison of three levels of ascertainment of antenatal medication use at Gugulethu Midwife Obstetric Unit
… Pregnant women are generally excluded from clinical trials due to ethical reasons. There are therefore minimal data available about the safety of most drugs during pregnancy by the time they come to the market, and post-marketing evaluation of medicine use during pregnancy is required. In …
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Pharmacometrics of dolutegravir and tenofovir: a quantitative approach to characterise drug-drug interactions, pharmacogenetics and optimise treatment
… or artesunate-amodiaquine was not clinically significant, and no dose adjustment is required when these are co-administered. Lastly, we demonstrate that polymorphisms within the UGT1A locus affect dolutegravir exposure among Africans. For tenofovir, we created a joint model that …
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