Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"Clinical Oncology"”.
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Machine Learning Methods for Single Cell RNA-Sequencing Data to Improve Clinical Oncology
… particularly when confronted with data from clinical oncology. This thesis presents the development and application of ML techniques for scRNA-seq data to address key computational challenges, with a focus on challenges in clinical oncology. It covers four key areas: identifying gene …
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Increasing Awareness of Fertility Preservation Options in Cancer Patients & Survivors
… Statistics Review 2010). The American Society of Clinical Oncology recommends that oncologists address fertility issues prior to cancer treatment, offering available preservation options to all patients or refer interested patients to reproductive specialists (Lee et al., 2006). However, patients …
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Precision Medicine in Immunotherapy and Lung Cancer
… to advance the goal of precision therapy in clinical oncology, encompassing tumour-specific and treatment-specific methods. It explores tumour-specific treatment such as platinum chemotherapy or immunotherapy for non-small cell lung cancer, and combines potential biomarkers from simple …
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Re-Designing Cancer Immunotherapy to Enhance Anti-Tumor Immunity
Immunotherapy has transformed the field of oncology. However, clinical challenges of toxicity and low response rate offer opportunities to develop novel, rational strategies to integrate into current clinical oncology treatment. To address these challenges, we designed a novel local mesenchymal …
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Pharmacological determinants of oxaliplatin neurotoxicity in patients undergoing cancer chemotherapy
… associations between neurotoxicity outcomes and clinical and pharmacological variables measured at baseline or during initial treatment in patients undergoing oxaliplatin-based therapy. Calcium and magnesium ions accelerated oxaliplatin degradation in vitro by interacting with the oxalate …
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Clinical Trial Enrollment In A Multidisciplinary Prostate Cancer
<p> <p>Purpose: Clinical oncology trials are hampered by low accrual rates. Less than 5% of adult cancer patients are treated on a clinical trial. We aimed to evaluate clinical trial enrollment in our Multidisciplinary Prostate Cancer Clinic and to assess if a clinical trial initiative, introduced …
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Assessing the impact of tumor evolution on oncology drug development and commercialization
… of developing and commercializing targeted oncology drugs directed at a specific tumor mutation instead of all forms and mutations of a single target. While oncologic drugs targeted to aberrant or overexpressed pro-proliferative proteins have revolutionized cancer treatment, tumors treated …
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Development of supervised and unsupervised pixel-based classification methods for medical image segmentation
… grade and estrogens reception (ER) status, to clinical management of the disease. Until now, histological grading and ER status assessment is based on the visual evaluation of breast tissue specimens under the microscope. More specifically, grading is determined on the visual estimation of …
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Micro- and millifluidic platforms for imaging agent synthesis
… basic understanding of biochemical processes and clinical diagnosis of diseases. One widely used molecular imaging technique is positron emission tomography (PET) that is especially useful for clinical oncology applications. PET has seen remarkable growth recently due to improvements in the …
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Quantifying the pro- and antimutagenic roles of DNA damage and repair
… reliable interpretation and applicability in clinical oncology. Lastly, the cross-species comparison shows that the fundamental laws of mutagenesis are acting similarly across eukaryotic organisms reminding that many mutational processes fuelling tumorigenesis are not exclusive to cancer, but …
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Transitions in Palliative Care: Referral Time and Healthcare Utilization in Advanced Stage Colon, Rectal and Lung Cancer Patients.
… of a chronic illness; American Society for Clinical Oncology (ASCO, 2012) guidelines recommend PCR within 8 weeks of advanced cancer diagnosis.</p> <p>Purpose: The purpose of this study was to examine the relationship among select socio-demographics, participant clinical characteristics, PCC …
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Pyrrolo[2,3-d]pyrimidine Classical Antifolates for Targeted Cancer Chemotherapy- Applications of Bioisosteric and Regioisomeric Substitutions for Improved Tumor-Selectivity and Potency
… is by far the most successful category of clinical oncology, having cured (complete remission (CR), without return) or provided clinical benefit to millions of people. However, since its earliest discovery, the major causes of failure of conventional cancer chemotherapy have been …
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The Use of Oncology Electronic Health Record Databases to Assess the Effectiveness of Breast Cancer Treatment
… well-suited for addressing relevant questions in clinical oncology that pertain to the safety and effectiveness of medications. They complement randomized trials by including frail and complex patients seen in routine care that reflect real-world practice patterns and treatment adherence. …
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Tracking Treatment Response and Resistance to Parp Inhibition (Talazoparib) In Hereditary Pancreatic Cancer.
… trial presented at the American Society for Clinical Oncology (ASCO) conference in 2019, maintenance therapy with Olaparib significantly delayed the progression of metastatic <em>BRCA</em> mutant pancreatic adenocarcinoma (PDAC) compared to placebo (7.4 months vs 3.8 months). Talazoparib, a …
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NEW INSIGHTS INTO PATHOGENESIS AND PROGNOSIS OF CANINE SARCOMAS
… studies and their application in veterinary clinical oncology. The majority of these studies have also been characterized by non-standardized and non-rigorous methods. Given these premises, the aims of this thesis were to identify valuable prognostic factors specific for different canine …
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Stromal-epithelial dynamics in response to fractionated radiotherapy
… to radiation is therefore a prime concern of clinical oncology. Post-operative radiotherapy has commonly been used for early stage breast cancer to treat residual disease. There is continued debate as to what might be the proper dose per fraction as well as the total dose of radiation that …
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Valor diagnóstico y pronóstico de nuevos biomarcadores de infección en pacientes oncológicos con neutropenia febril postquimioterapia.
… recomendaciones de la ASCO (American Society of Clinical Oncology), donde se recomienda el empleo de biomarcadores séricos para completar y mejorar a las actuales escalas clínicas, por lo que creemos de interés el estudio de diferentes biomarcadores. Dentro de los estos, la proteína C reactiva …
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