Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"Clinical Microbiology"”.
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Managing for quality in clinical microbiology services.
The technical quality of the work performed in clinical microbiology laboratories is regularly monitored, by external and internal schemes. Among the factors which might affect quality, attitudes of the laboratory staff are rarely considered. In this study, three concepts recognised by occupational …
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A multi-domain process design and improvement framework
… expanded the range of processes available to the clinical microbiology laboratory, however, integrating these new processes into a comprehensive surveillance system presents significant challenges. Many of these new technologies are still in early stages of development, require multidisciplinary …
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From genomes to metagenomes: Big data analysis of microbes related to public health
… individuals. Despite recent developments in clinical microbiology, our understanding of the molecular and ecological mechanisms underlying the pathogen-host-environment interplay, remains incomplete. In this work, we applied cutting-edge laboratory and bioinformatics techniques to profile …
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Molecular methods for the detection of TEM- and SHV-related beta lactamase genes in members of the Enterobacteriaceae
… to antibiotics is a common and important clinical problem. Beta lactam resistance in Gram negative bacilli is mediated predominantly by beta lactamases, enzymes able to hydrolyse the beta lactam ring. The commonest plasmid mediated beta lactamases in the Enterobacteriaceae are those …
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Combatting β-lactamase-mediated antimicrobial resistance: from novel assays for inhibitor discovery to new diagnostics
The clinical utility of β-lactams, the most prescribed antibiotics worldwide, is endangered due to the production of β-lactamase enzymes by pathogenic bacteria. Collectively, these enzymes can inactivate every clinically available β-lactam antibiotic via a hydrolytic mechanism. Thus, infections …
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Human cases of Staphylococcus pseudintermedius with probable transmission between companion animals to humans in Saskatchewan
… if this is due to technological advancements in clinical microbiology, increased pathogenicity for humans or close proximity of humans and animals living together. Reports of this organism being recovered from specimens from humans might suggest an increased prevalence in human infections and/or …
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Implementation of molecular techniques in the diagnosis of legionnaires’ disease and in the investigation of legionella outbreaks
… fresh water sources, consequently typing of both clinical and environmental isolates is crucial to rapidly identify the possible source and prevent further cases. Legionellae are difficult to isolate by culture, moreover as respiratory samples are not available for up to 65% patients, alternative …
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Development of A Molecular Gram-Stain Assay For The Diagnosis of Blood Stream Infections Associated With Sepsis
… differentiate these two groups.</p> <p>Eighteen clinical blood samples from suspected sepsis patients were analyzed using the MGS assay and compared to results obtained from the Memorial Hermann Hospital Clinical Microbiology Laboratory’s blood culture and Gram- strain analysis. There was 100% …
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Molecular Engineering Approaches against Germs, Spores and Biofilm Formation
… for as long as the history of modern day microbiology and materials science themselves. With the rapid advances of molecular engineering in the past few decades, engineers as well as scientists are now equipped with new tools to study and solve these age-old problems. In the wake of these …
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DARK-PIGMENTED, AMOXICILLIN-RESISTANT, BACTERIAL SPECIES IN CHRONIC PERIODONTITIS MICROBIOTA IDENTIFIED WITH MATRIX ASSISTED LASER DESORPTION/IONIZATION TIME-OF-FLIGHT MASS SPECTROMETRY.
… involving amoxicillin, which may lead to clinical therapeutic failures in chronic periodontitis therapy. Recent studies using phenotypic methods have identified the in vitro growth of Prevotella intermedia/nigrescens in the presence of therapeutic threshold concentrations of amoxicillin, …
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Identification of The Causative Bacteria In Musculoskeletal Infections Using 16S Rdna - Denaturing Gradient Gel Electrophoresis Analysis
… for pathogen identification. However, these clinical laboratory methods are frequently inadequate for the identification of the causative agents, because a large percentage (25-50%) of confirmed musculoskeletal infections are false negatives in which no pathogen is identified in culture. My …
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Developments in the Mutant Prevention Concentration: A Novel Approach to Antimicrobial Susceptibility/Resistance Issues
… which limits its implementation into clinical microbiology laboratories. In an attempt to simplify the current MPC protocol we developed a modified MPC method, the microbroth dilution method, which requires two fewer days to complete than the current or traditional method. MPC values …
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Human papillomaviruses of skin and genital lesions
Around 5% of all cancer cases worldwide are caused by human papillomavirus (HPV) which has been established as the cause of cervical cancer and genital warts (condylomas). Cutaneous HPV types have been weakly associated with non-melanoma skin lesions such as squamous cell carcinoma (SCC) and …
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The Colonization Strategies of Nontypeable Haemophilus influenzae - Bacterial Colonization Factors and Vaccine Development
Nontypeable Haemophilus influenzae (NTHi) is a remarkably proficient colonizer of the human respiratory tract. The aim of this thesis has been to characterize currently known, and identify novel, bacterial factors involved in the key processes of colonization and pathogenesis, namely adherence to …
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Proteomic comparison of Amoxicillin resistant and susceptible periodontal Provotella Intermedia and Provotella Nigrescens clinical isolation with Matrix-Assisted Laser Disportion Ionization Time-Of-/flight mass spectrometry
… with periodontal health. However, many clinical isolates of P. intermedia and P. nigrescens may exhibit resistance to β-lactam antibiotics prescribed in periodontal therapy via expression of β-lactamase enzymes. Conventional methods of in vitro antibiotic susceptibility testing entail …
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Elucidation of the Molecular Mechanisms That Contribute to Variation in Susceptibility Testing Show the Need for Alternative Detection Methods of KPC-producing Gram-negative Bacteria
… pathogens using current detection methods in the clinical laboratories are the biggest challenges the KPC-producing organisms pose. Although in vitro testing indicates that the KPC β-lactamase can efficiently hydrolyze the carbapenems, multiple studies have reported variability in susceptibility …
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Molecular Mechanisms of Antimicrobial Resistance In Multi-Drug Resistant Enterococci
<p>Antibiotic resistance is a major global public health threat. Enterococci are recalcitrant, nosocomial pathogens that can be intrinsically resistant to valuable antibiotics, like beta-lactams, or evolve resistance to all existing antimicrobials. The LiaFSR system regulates resistance to cell …
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ΚΑΤΑΝΟΜΗ ΒΙΟΤΥΠΩΝ ΚΑΙ ΟΡΟΤΥΠΩΝ ESCHERICHIA COLI ΣΕ ΚΛΙΝΙΚΑ ΥΛΙΚΑ. ΣΥΣΧΕΤΙΣΗ ΦΑΙΝΟΤΥΠΩΝ ΑΝΤΙΣΤΑΣΕΩΣ ΚΑΙ ΟΡΟΤΥΠΩΝ
… THE EXAMINATION OF 249 SAMPLES OF VARIOUS CLINICAL MATERIALS (190 URINE, 29 PUS, 18 VAGINAL DISCHARGE AND 12 VARIOUS), FROM 7 HOSPITALS FOR THE ISOLATION OF E. COLI. THE MICROORGANISMS WERE FURTHER CLASSIFIED TO BIOTYPES AND RESISTANCE PHENOTYPES. FOR THE CLASSIFICATION TO BIOTYPES, 25 …
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Automatizace vyhodnocení diskové difuze pomocí multiplatformní aplikace s integrací expertních vyhodnocovacích pravidel
V této diplomové práci je navržena, implementována a integrována multiplatformní aplikace pro automatizované vyhodnocení diskové difuze (DD) při testování citlivosti na antibiotika (AST). Zpracovací řetězec DD zahrnuje detekci Petriho misek vylepšeným detektorem FCOS s mAP. = 98,76% a mAP. = …
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