Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Clinical Immunology"”.
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Generating immunological signatures of diseases by multiplex analysis of single cells
… populations are highly desired in basic and clinical immunology. Microengraving is a process that uses a dense, elastomeric array of nanowells to generate microarrays of proteins secreted from large numbers of individual live cells. In this thesis, we improved the sensitivity and multiplicity …
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A cross-sectional study of Ig-E mediated food sensitisation and food allergy in an unselected population of South African children aged 12-36 months
… manuscript according to Current Allergy and Clinical Immunology Journal requirements. Results The sample consisted of; 39% black African, 20% Caucasian and 41% mixed race participants, with a median age 26 months (IQR: 22-31). Amongst 121 participants (66% response rate, 92% participation …
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Cellular immune ontogeny and birth transcriptome in HIV-exposed uninfected infants
Background. In some regions of Sub-Saharan Africa, up to 30% of newborns are born to mothers infected with human immunodeficiency virus (HIV). Maternal antiretroviral treatment (ART) has reduced vertical transmission to lower than 1%. Despite the success of prevention of mother-tochild transmission …
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Vaginal microbial diversity of the genital tract of South African adolescent females
Young, reproductive-aged women are at highest risk of acquiring human-immunodeficiency virus (HIV). The Women's Initiative in Sexual Health (WISH) study was designed to investigate potential biological reasons for this high risk in HIV negative, South African adolescent females. Little is known …
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The effects of fibroblast growth factor-2 om human bone marrow cells
Bibliography: leaves 163-191.
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The penetration protease of the cercariae of Schistosoma mansoni
This thesis is concerned with a study of the proteases released by the cercariae of Schistosoma mansoni while penetrating mammalian skin. The proteases present in secretions collected from the preacetabular glands of cercariae were shown to be active against ¹²⁵I-labelled fibrin but not against …
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The role of the cytolytic mediators, granulysin and perforin, in tuberculosis
Protective immunity against mycobacterial infection requires an effective cytolytic response, in addition to an intact Type l (Th1) cytokine pathway. Natural killer (NK) cells and cytolytic T-cells (CTL) are essential components of protective immunity against tuberculosis (TB) and mediate …
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CD4 and CD8 T-cell responses to acellular pertussis and rotavirus vaccination in breast-fed HIV exposed, uninfected infants
Introduction: Vaccination is one of the most efficient ways to prevent infectious diseases, however due to the naivety and regulation of immunity found in infants, induction of vaccine-mediated immunity is challenging. Respiratory and diarrheal diseases are major contributors to infant mortality. …
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In vivo effects of South African traditional medicines against Mycobacterium tuberculosis in experimental mice
Although it is more than 100 years since Robert Koch discovered the tubercle bacillus, and more than 40 years since effective chemotherapy became available, the incidence of tuberculosis is increasing in much of the developing world and has recently re-emerged as a public health problem in …
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Characterization of a polypeptide factor that inhibits the growth of a human breast cancer line in vitro
This thesis concerns a melanoma-derived growth regulatory factor that inhibited proliferation of several malignant human cell lines, and, in particular, a line designated UCT-BR-1, which was derived from a human breast cancer metastasis. The work is presented in four chapters. Chapter 1 provides a …
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Metabarcoding pollen to identify allergenic species of grasses (Poaceae) and ragweed (Ambrosia spp.) across six monitored sites in South Africa
Background and aims Aeroallergens contribute to the global burden of non-communicable diseases, causing allergic conditions such as rhinitis, conjunctivitis, and asthma. Pollen is the second most important contributor, and despite cross-reactivity between allergens, patients often experience …
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Cytotoxic T lymphocyte biology under the microscope
… keeps the researcher in touching distance of clinical translatability and relevance. This thesis is an amalgamation of several projects I have undertaken over the past four years in the Griffiths lab, all aimed at understanding different aspects of CTL biology. Throughout these different …