Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 25 for “"Clinical Epidemiology"”.
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Investigating kidney disease clinical epidemiology using routinely collected administrative data and proteomics
… invaluable to better understand kidney disease epidemiology. This thesis explores the detection and characterization of acute kidney injury (AKI), chronic kidney disease (CKD), acute-on-chronic kidney disease (A-on-CKD) and kidney disease progression using rule-based laboratory- and …
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Epidemiology of systemic Candida infections: studies to pursue the molecular and clinical epidemiology
Contains fulltext : mmubn000001_245903178.pdf (Publisher’s version ) (Open Access)
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The use of health economics in the early evaluation of regenerative medicine therapies
… of technologies without clearly defining the clinical problem. In particular, the marginal gain in benefit over alternative treatments is frequently overlooked. A large part of this thesis is therefore concerned with the clinical epidemiology of the conditions at which treatment is targeted. …
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Process of Care and Outcome of Critically Ill Patients with Traumatic Brain Injury
This thesis used clinical epidemiology methods to examine the relationship between process of care and outcome of critically ill patients with traumatic brain injury (TBI). First, I evaluated the association between intracranial pressure (ICP) monitoring use and mortality after severe TBI at the …
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Clinical management of patients with persistent dyspeptic symptoms.
Contains fulltext : 139929.pdf (Publisher’s version ) (Open Access)
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The Effect of Electroshock on the Passage of Bacteria From a Contaminated Transducer Past a Protective Membrane into a Disposable Chamber Dome
<p>Infection related to use of Intra-arterial Hemodynamic Monitoring Devices is a serious complication. In an attempt to decrease the risk of infection presterilized chamber domes were developed to isolate the patient vascular system from the pressure transducer. Users were informed by …
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A study of Door Pulls on Isolation Carts in a General Hospital for Evidence of Contamination
… Following this the specimens were sent to the clinical laboratory where they were innoculated on blood agar plates and in thio- glycolate broth. These were incubated at 37.5° Centigrade for seventy-two hours. Plates were examined daily for any bacterial growth. Any growth seen was restreaked on …
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Secular Trends in Life Expectancy by Diet Status Among Never Smoking Seventh-day Adventists
<p>To evaluate how life expectancy changed by age and secular time from 1960 through 1988, two cohort studies, the Adventist Mortality Study (AMS, 1960-1985, n = 27,530) and the Adventist Health Study (AHS, 1976-1988, n = 34,192) were combined. The life expectancy of omnivores was compared to …
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Do women with unintended births use highly effective postpartum contraception? An analysis of data from the National Survey of Family Growth, 2006-2010
OBJECTIVES: Half of all U. S. pregnancies are unintended, and of these, about 6 out of 10 are carried to term. These are known as “unintended births,” and they are at elevated risk for adverse social, economic and health outcomes. The goal of this study was to examine, using the latest data from …
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Primary Ciliary Dyskinesia: An Epidemiological Exploration. Furthering our understanding of the burden of disease in PCD
… part, due to the heterogeneous and non-specific clinical presentation, and the lack of a gold standard diagnostic test. There are also known limitations with lung function monitoring in PCD, in that spirometry, the most common lung function test, is known to be insensitive to the early stages of …
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A Risk Stratification Model for Adult Patients with Obstructive Sleep Apnea: Development and Evaluation
… guidelines. Studies two and three linked a clinical sleep database to Ontario health administrative databases for the period of 1991 to 2011 to examine the relationship between OSA variables and a composite CV outcome and incident diabetes. For the latter, we assembled a cohort free of …
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Redefining and Reclassifying Acute Traumatic Cervical Incomplete Spinal Cord Injury with Special Reference to Central Cord Syndrome: Implications for an Aging Population
… of the global aging population and the shifting epidemiology of acute spinal cord injury (SCI), there is a critical need to revisit the definition and clinical management of central cord syndrome (CCS). This dissertation investigated the hypothesis that the neurological outcomes of patients with …
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Contamination of Stuffed Cloth Toys on a Pediatric Unit
<p>The purpose of the study was to determine if cloth stuffed toys used by children in the pediatric unit of Loma Linda University Hospital carry microbacterial pathogens that are the same type as those pathogens found in the throat of the child using the toy. A second purpose was to determine how …
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Vitamin D, Calcium and Blood Pressure in the U.S.
<p>Vitamin D and calcium have received increased attention for their potential roles in improving cardiovascular health. The active form of vitamin D, 1,25-hydroxyvitamin D (25[OH]D), may influence blood pressure by increasing gastrointestinal calcium absorption. The objectives of this study were …
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Application of Informatics Tools to Facilitate the Practice of Precision Medicine with Genomic Testing and Clinical Data
… care. Factors such as patient demographics, clinical history, and lab test values have well understood effects on treatment outcomes and influence decision making. However, effective inclusion of biomolecular data such as protein expression and DNA sequencing data within the practice of …
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The Association of Fluid Intake With Total Natural-cause Mortality, Coronary Heart Disease and Fatal Stroke
<p>Hypohydration may be more widespread than realized since it does not always arouse a sense of thirst. When thirst is felt, it is often ignored, or satisfied before euhydration is achieved. There is growing evidence indicating that hypohydration contributes to acute and chronic illnesses, and to …
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Epidemiology, diagnosis and aspects of treatment in persons with serious mental illness and co-occurring substance use disorders
… are associated with a number of demographic and clinical factors, including worse clinical outcomes. Although the clinical profile and negative impact on prognosis has been well characterised in research on dual diagnosis samples from high income countries, little is known in the low- and …
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Genetic Predictors of Metabolic Side Effects of Diuretic Therapy
… in response to HCTZ from two different clinical trials: the Pharmacogenomic Evaluation of Antihypertensive Responses (PEAR) and the Genetic Epidemiology of Responses to Antihypertensive (GERA) studies. Two SNPs (rs12279250 and rs4319515 (r2=0.73)), located at 11p15.1 in the NELL1 gene, …
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Public Health Policy: An Ethical Analysis of Quarantine
<p>As a public health measure quarantine has both historical and contemporary significance both in the United States and abroad. On the surface it represents a low-cost, low-tech way in which the spread of disease can be mitigated as its core requirement is that those who may have been exposed to …
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Improving Patient Care Outcomes to Reduce Recurrent Admissions of Patients with Chronic Obstructive Pulmonary Disease
… stays (Miravitlles et al., 2002). Access to clinical excellence for the successful transition from the hospital, across settings, prevented readmissions. The impact of reducing recurrent admissions for patients discharged with chronic obstructive pulmonary disease improved patient care …
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