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Showing 1 to 18 of 18 for “"Click reactions"”.
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Transformation of biomass carbohydrates by transition metal catalysts
… the attached azide group becomes important for click reactions. Click reactions involve two small functional groups that selectively combine. In this case the azide is clicked to an alkyne group to form a triazole. The alkyne group is part of a naphthalimide compound that has strong fluorescent …
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Design, Synthesis, and Characterization of Glycodendrons Through Small Molecule and Linear Polymer Models
… of glycopolymer-dendron thiol-ene coupling reactions with the long-term goal of increasing biocompatibility of near infrared (NIR) fluorophores for bioimaging applications. A design of experiments was used with small molecule model compounds to determine the parameters for successful …
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Synthetic polypeptide-based hydrogel systems for biomaterials
… with modified side chains available for click chemistry at quantitative grafting efficiencies. Herein, new schemes for hydrolytically stable versions of the polymer system with click functionality are introduced. Additionally, a new random copolymer, …
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Bioorthogonal Reactions: Synthesis and Evaluation of Different Ligands in Copper Catalyzed Azide-Alkyne1,3-Dipolar Cycloaddition (CuAAC)
… features that qualify it to be one of the best click reactions. Its applications have been shown in different aspects and for multiple purposes. The oxidative degradation of biological systems (labile proteins and live cells) is, however, generally recognized as the major problem when using this …
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Single-chain nanoparticle based catalysts
… alkyne–azide cycloaddition (CuAAC), “click” reactions, or the photoreduction of azido groups to amines. The nanoparticles are shown to have significantly higher activity when compared to analogous small molecule catalysts. Structure-activity relationships and reaction mechanisms are …
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From the Making to the Tuning to the Use of Chlorins for Biomedical Applications
… endeavor, we demonstrate that three successive click reactions yield multifunctional chlorin platforms appended with either S-linked or O-linked polyethyleneglycol chains (S-PEG or O-PEG, respectively) and a carboxylate-linker to a free base of a pyrrolidine ring form from a 1,3-dipolar …
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Design and synthesis of cyclometalated transition metal complexes as functional phosphorescent materials
… derivatives, referred to as the "click" ligands, are used to build phosphorescent Ir(III) and Pt(II) compounds. The robust and tolerant nature of the copper mediated 1,3-dipolar cycloaddition reactions offers great flexibility in the molecular design. Chapter 1 and Chapter 2 focus …
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Enzymatic acylation of starch
… with azide containing molecules, through "click" reactions (dipolar cycloaddition). Investigation of other reaction systems for enzymatic starch acylation, revealed nonenzymatic transesterification of vinyl decanoate with starch in DMSO. On the other hand, the ionic liquid …
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Chemical tools to probe carbohydrate recognition and glycoconjugate biosynthesis
… (4.07) utilising Cu(I)-catalysed click reactions. These compounds were used to mimic authentic substrates for Trypanosoma cruzi trans-sialidases in order to block Trypanosoma cruzi macrophage invasion.
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Functional polymer layers with protected amines
… reaction using one of the most efficient click reactions, the Cu(I) catalyzed Huisgen 1,3-dipolar cycloaddition between terminal acetylenes and azides to attach further functionalities through the formation of a stable 1,4-disubstituted 1,2,3-triazol ring . The combination of nitroxide …
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Step-growth thiol-ene photopolymerization to form degradable, cytocompatible and multi-structural hydrogels
… gel systems, it was found that thiol-ene click reactions formed hydrogels with higher crosslinking efficiency. However, thiol-ene hydrogels still contained significant network non-ideality, demonstrated by a high dependency of hydrogel swelling on macromer contents. In addition, the …
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Adiciones 1,4-conjugadas a deshidroalaninas quirales para la síntesis de aminoácidos no naturales
… new type of reactivity based on the 1,4-addition reactions is presented; however, in this case we employed radicals to form C-C bonds, which is known as the Giese reaction. Moreover, these radicals are generated by blue light photocatalyzed reactions. This reactivity allows the synthesis of …
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Micro- and millifluidic platforms for imaging agent synthesis
… radiometal-based PET radiotracer synthesis. “Click chemistry”, or more specifically Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC), was utilized to address the concern regarding site-specific attachment of BFCs to BMs. CuAAC, like other “click reactions”, yields products with few side …
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Kinetics of Polymer Interfacial Reactions
… different challenges were addressed to explore click reaction kinetics of end functional reactants (small molecules and polymers) reacting to self-assembled monolayers (SAMs) on solid substrates: first of all, functional surfaces modified with azide SAMs are presented in Chapter 3. Secondly, a …
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Click Chemistry on DNA and Targeting RNA structure with Peptide Boronic Acids
The utilization of click chemistry to perform inter- and intramolecular ligation on DNA has become ubiquitous in the literature. Advances in copper (I) stabilizing ligands that prevent DNA degradation via redox pathways have provided nucleic acid researchers access to the efficiency and …
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Synthesis of fluorinated polymers in supercritical carbon dioxide (scCO₂)
… and VDF concentration. To allow for isothermal reactions high CO₂ contents ranging from 61 to 83 wt.% were used. The high-temperature, high-pressure conditions were required for homogeneous phase polymerization. These conditions did not alter the amount of defects in VDF chaining. Scanning …
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SYNTHESIS AND CHARACTERISATION OF NOVEL BIOPOLYMERS VIA CLICK CHEMISTRY
… azide–alkyne cycloaddition, as an efficient Click reaction, for the synthesis of novel biopolymers with a broad range of potential medical/industrial applications. The strategy is to develop a powerful tool for the synthesis of libraries of materials, which will be discussed in separate …
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Design, Synthesis and Biological Evaluation of Novel Cannabinoid Antagonist
… were synthesized via a one-pot regiospecific click/acylation reaction sequence from 1-azido-2,4-dichlorobenzene and commercially available arylacetylenes. From the structure-activity studies the 5-(4-chlorophenyl) congeners exhibited the most potent CB1 receptor affinities relative to other …