Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 32 for “"Cleaved Caspase-3"”.
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Microrna 21 targets B Cell Lymphoma 2 (Bcl2) Mrna to increase beta cell apoptosis and exosomal Microrna 21 could serve as a biomarker of developing Type 1 Diabetes Mellitus
… cell count and viability, and increased cleaved caspase-3 levels, suggesting increased cell death. In silico prediction tools identified the anti-apoptotic mRNA B Cell Lymphoma 2 (BCL2) as a conserved miR-21 target. Consistent with this, miR-21 overexpression decreased BCL2 transcript and …
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Avaliação imuno-histoquímica da proliferação e morte celular em neoplasias mamárias malignas caninas
… were used as primary antibodies, as well as cleaved anti-Caspase-3. Considering 61 samples, by means of the histopathology procedure, five carcinosarcomas, nine carcinomas in mixed tumors, six complex tubular adenocarcinomas, 12 primary tubular adenocarcinomas, 13 complex papilliferous …
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The intrinsic role of SOCS1 in intestinal epithelial cells
… ER stress response (spliced Xbp1) and apoptosis (cleaved caspase 3 protein), as well as EdU incorporation proliferation assays were then performed. Our results indicate that the loss of Ifng and Socs1 is not affecting colonoid growth and renewal capacity of stem cells, goblet cell differentiation, …
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The effect of doxorubicin on the U2OS cell cycle
… with PI. Apoptosis levels are monitored using cleaved Caspase 3 and cleaved PARP. The percentage of 10 [mu]M cells undergoing apoptosis increased steadily over 48 hours, while the 2 [mu]M and untreated cells maintained constant low levels of apoptosis. Both cellular senescence and apoptosis put …
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Role of ATG 5 in ER stress-induced apoptosis in meniscus.
… lipidation of LC3 and increased activation of Cleaved Caspase 3, which promoted meniscus cell apoptosis. Pretreatment of meniscus cells with 4-phenyl butyric acid (PBA), a small molecule chemical chaperone that alleviates ER stress or with MG-132, a proteasome inhibitor, restored normal levels …
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Expression of Survivin : Possible Predictor of Local Recurrence after Curative Resection for Rectal Cancer
… staining for p53, bcl-2, survivin and cleaved caspase-3 were performed on paraffin-embedded tissue sample of 46 rectal cancer. By clinicopathological data, risk factors for local recurrence were positive nodes (45% vs 69.6%, P<0.046) and lateral margin invasion(1.7% vs 30.4%, P<0.000). …
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APPLICATION OF COMPLEMENTARY METHODS BEYOND STANDARD PATHOLOGY TO INVESTIGATE KETAMINE NEUROTOXICITY IN MODELS OF PEDIATRIC ANESTHESIA
… and immunohistochemical markers (H&E, Cleaved Caspase-3, γH2AX, GFAP, Iba-1, Olig2, NeuN). A preliminary study compared whole-area analysis with standardized microscopic field sampling, demonstrating that 12 fields per region provided quantitative results comparable to whole-area …
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Compound 49b: A Novel Beta-Adrenergic Receptor Agonist in the Treatment of Diabetic Retinopathy
… factor!alpha (TNF-!) levels, and cleavage of caspase 3 were analyzed after 2- and 8-months or 2- and 6-months of treatment.</p> <p>Results. Protein levels of TNF-! and cleaved caspase 3 were increased in the retinas of diabetic rats, but were returned to normal values following 1mM Compound …
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Differential effects of epidermal growth factor receptor inhibitors on glioblastoma multiforme
… signaling molecules showed a greater presence of cleaved caspase 3, a hallmark of apoptosis, in gefitinib treated cells expressing PTEN than in those cells treated with CI-1033. Cells deficient in both Ink4A/ARF and PTEN did not demonstrate any induction of cleaved caspase 3 following either …
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Yap1 Expression Predicts Sensitivity to Dual Akt/P70S6K Inhibition In Ovarian and Uterine Malignancies
… (CD31) indices and increased cell death (cleaved caspase-3) markers. Synergy between MSC2363318A and paclitaxel was observed <em>in vitro </em>in protected (IC50 ≥ 5 µM) cell lines. RPPA identified YAP1 as a candidate marker to predict cell lines that were most sensitive to MSC2363318A …
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The Role of Wnt3a in Ischemic Stroke
… increased FOXM1 survival protein and reduced Cleaved Caspase-3 levels. In summary, wnt3a decreases neuronal apoptosis and improves neurological deficits through Frizzled-1/PIWI1a/FOXM1 pathway after MCAO in rats. Therefore, wnt3a is a novel intranasal approach to decrease apoptosis after …
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Harnessing the Immunomodulatory Potential of Radiofrequency Ablation to Improve Therapeutic Outcomes in Pancreatic Ductal Adenocarcinoma
… increase in apoptotic cell death as measured by cleaved caspase-3 expression, significant increase in collagen deposition, a decrease in the expression of macrophage migration inhibitory factor (MIF) levels, and elevated hypoxia-inducible factor 2-alpha (HIF2α) expression were among the important …
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Induction of Caspase-Dependent Death By Proteasome Targeted Therapy In Glioblastoma
… I then determined that both BTZ and MRZ induced caspase-dependent death in GBM cells that was dependent upon activation of caspase 9. Using an orthotopic xenograft model of GBM, I found that both BTZ and MRZ increased levels of the proteasome substrates p21 and p27 in intracranial tumors, with …
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Elucidating the role of bone morphogenetic protein-4 in regulating secondary injury mechanisms following traumatic spinal cord injury
… first time, we demonstrate that BMP4 promotes cleaved caspase-3 expression in cultured neurons and oligodendrocytes and that acute BMP inhibition attenuates apoptosis and lipid peroxidation after SCI. We also show that BMP4 directly inhibits oligodendrocyte differentiation in NPCs and OPCs in …
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The role of CysLT1R in animal models of colorectal cancer
… expression, increased expression of p21WAF/Cip1, cleaved caspase 3 and caspase-cleaved keratin 18. An impaired tumor angiogenesis was also demonstrated by detection of increased levels of VEGF and reduced vessel size. We also investigated the role of CysLT1R in 1) FAP/sporadic colorectal cancer by …
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Impacts of dietary obesity on muscle stem cell behaviors
… events as revealed by the expression of cleaved caspase 3 (P < 0.001). To investigate further the impact of obesity on SC quiescence and cycling properties in vivo, we used an inducible H2B-GFP mouse model to trace the turnover rate of GFP and thus cell division under normal and obese …
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Neuroprotective effects of PACAP, VIP and NAP against hyperglycaemic retinal damage
… levels of the pro-apoptotic elements, such as cleaved caspase-3. These results raise the opportunity for the use of these peptides as a possible therapeutic or preventive methods in treating diabetes.
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Therapeutic targeting of DGKA-mediated macropinocytosis in lymphangioleiomyomatosis
… the expression levels of TSC2, tS6R, pS6R, Cleaved PARP, Cleaved Caspase 3 and Actin. siRNA induced Htr2a knockdown and shRNA induced DGKA knockdown cell culture models were used to define the dual functions of ritanserin and observe their effects on macropinocytosis and cell proliferation. …
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Glioma: A Tale of Corticosteroids, Thiopurines and Proposed Novel AntiGlioma Small Molecules
… significant decrease in PCNA and Ki67 but not in cleaved caspase-3 staining. Decreased tumor cell growth could compromise the responsiveness of tumor cells to chemotherapy and/or radio-therapy, because cancer therapeutics often target rapidly growing cells. In addition, we found that …
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Identification of a Novel Regulator of ER Stress-Induced Apoptosis
… conditions and analyzed for differential cleaved caspase 3 activity. CG8108 was identified in the screen as a strong loss-of-function suppressor of ER stress-induced apoptosis and the gene was selected for further study. This thesis shows that CG8108 is necessary for efficient splicing of …
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