Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 25 for “"Clear Cell Renal Cell Carcinoma"”.
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SMARCB1 Maintains Lineage Fidelity in Clear Cell Renal Cell Carcinoma
… cancer types remain poorly understood. Using clear cell renal cell carcinoma (ccRCC) as a model, I characterise mechanisms that underlie lineage factor dependence in cancer. Using CRISPR/Cas9 loss-of-function screening coupled with in vitro and in vivo validation I show that the loss of …
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Prognostic Significance of Chromosome 9p Deletion in Clear Cell Renal Cell Carcinoma
… role of chromosomal copy number aberration in renal cell carcinoma (RCC) has been explored in several studies. Chromosome 9p deletion was reported as an independent prognostic factor in clear cell subtype (ccRCC). The findings from these studies initially appeared promising however they were of …
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Endogenous Reporter Systems for High-Throughput Functional Screening in Clear Cell Renal Cell Carcinoma
… the development of therapeutic approaches. In clear cell renal cell carcinoma (ccRCC), loss of von Hippel-Lindau tumour suppressor (VHL), seen in 90% of ccRCCs, leads to the stabilization of hypoxia inducible factor HIF2A and aberrant expression of its downstream targets such as the chemokine …
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Investigating the role of SWI/SNF chromatin remodelling complex in Clear Cell Renal Cell Carcinoma
… PBRM1 is mutated in approximately 40% of clear cell type renal cell carcinoma (ccRCC). In this study, we characterised the composition of SWI/SNF complexes in ccRCC cells finding that the PBRM1 and SMARCC1 subunits are frequently depleted in ccRCC cell lines. Furthermore, using a ccRCC …
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Autologous Proliferative and Immunobiological Modelling of Patient-Derived Clear Cell Renal Cell Carcinoma and Kidney Organoids
… emerged as the new standard of care for advanced clear cell Renal Cell Carcinoma (ccRCC), the deadliest urological malignancy. However, both efficacy and toxicity of immunotherapies is highly patient-specific and difficult to predict. This underscores the need for robust preclinical models of …
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Identification and characterisation of HNF1B as a pro-tumorigenic lineage factor in clear cell renal cell carcinoma
Clear cell renal cell carcinoma (ccRCC) is the most common subtype of renal cancer. ccRCCs exhibit considerable genetic intratumour heterogeneity, and current therapies lack long-term efficacy due to drug resistance. Novel therapeutic targets are thus required to combat this disease. The most …
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A KLF6-driven transcriptional network links lipid homeostasis and tumour growth in clear cell renal cell carcinoma
Clear cell renal cell carcinoma (ccRCC) is characterised by frequent inactivation of the VHL tumour suppressor gene and consequent accumulation of HIF2A that drives tumourigenesis. The current clinically-approved therapies for ccRCC are those targeting the angiogenesis and mTOR signalling pathways, …
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DEVELOPMENT OF BISPECIFIC T CELL ENGAGERS TARGETING CARBONIC ANHYDRASE 9 FOR THE IMMUNE THERAPY OF CLEAR CELL RENAL CELL CARCINOMA
Advanced clear cell renal cell carcinoma (ccRCC) is responsible for nearly 70% of kidney cancers and 10,000 yearly deaths in the Unites States. While immunotherapies have demonstrated potential, poor chances of long-term survival remain for advanced cases. Yet to reach patients are bispecific T …
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Prognostic significance of preoperative neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in patients with non-metastatic clear cell renal cell carcinoma
… for recurrence in patients with non-metastatic clear cell renal cell carcinoma (RCC). Material & Methods: We retrospectively reviewed the medical records of 341 patients (232 men and 109 women, mean age of 54.9 years) with non-metastatic clear cell RCC who underwent radical or partial …
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Diagnostic and prognostic DNA methylation biomarkers of renal clear cell carcinoma /
Clear cell renal cell carcinoma (ccRCC) is the most common type of kidney tumor with the highest incidence rates in Lithuania. CcRCC is characterized by the highest mortality rate of genitourinary cancers, therefore, new diagnostic and/or prognostic biomarkers are urgently needed. Considering this, …
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Von Hippel-Lindau Syndrome: Characterization of a Potentially Novel VEGF-A Isoform and Elucidation of Molecular and Vascular Mechanisms of Observed Phenotypic Changes
… cancer in neurological tissues, the kidneys, adrenal glands, pancreas, and liver, including neurological hemangioblastoma (HB), pheochromocytoma (PCC), pancreatic neuroendocrine tumors (PNET), pancreatic and renal cysts, and clear cell renal cell carcinoma (ccRCC). The disease process follows …
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Ageing and regeneration-associated transcriptional state transitions and tumour-stroma interaction in early renal carcinogenesis
… most common cancers in the world, among which clear cell renal cell carcinoma (ccRCC) is the most common subtype. VHL inactivation is the most common mutation seen in ccRCC with more than 90% of tumours had clonal disruption of the VHL pathway. Although it is the initial oncogenic insult in …
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Role of PBRM1 in regulation of the HIF pathway
… cancer types such as pancreatic, breast, and renal. Interestingly, PBRM1 and VHL are the most frequently mutated genes in clear cell Renal Cell Carcinoma (ccRCC). Mutations or loss of VHL leads to upregulation of both HIF1α and HIF2α. However, recent studies indicate that HIF1α and HIF2α play …
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Comparative Analysis of Radiologically Measured Size and True Size of Renal Tumors
… radiologically measured size and true size of renal tumors. MATERIALS AND METHODS: The data from 238 patients who underwent radical or partial nephrectomy for a renal tumor at our institution were reviewed. Radiologic tumor size defined as the largest diameter on a CT scan was compared to …
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Notch Signaling in Neuroblastoma and Renal Cell Carcinoma
The Notch signaling pathway governs cell functions essential for normal development and organogenesis. Aberrant Notch signaling has been implicated in tumorigenesis by perturbing control of proliferation, differentiation, apoptosis, migration and angiogenesis. Neuroblastoma is an embryonal tumor …
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Role of Hypoxia-inducible Factor in Kidney Cancer
Cellular adaptation to conditions of stress is critical to the survival of all organisms. In mammalian cells, reduced oxygen availability, or hypoxia, triggers a myriad of alterations within molecular pathways aimed at ensuring sustained viability and functionality of vital organs. The master …
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HIF2a regulates ccRCC tumorigenesis through activation of cell cycle regulators
Clear cell renal cell carcinoma (ccRCC) is the most frequent type of kidney cancer, with 50% 5-year survival. Genetically, ccRCCs are characterised by inactivation of VHL which is lost in 90% of cases. Inactivating mutations of VHL lead to stabilisation of HIF2α which in turn drives the expression …
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Mechanisms of Synthetic Lethality in Renal Cell Carcinoma
Clear cell renal cell carcinoma (ccRCC), the most common subtype of kidney cancer, is characterised by biallelic inactivation of the von Hippel-Lindau (*VHL*) tumour suppressor gene, and inherited loss-of-heterozygosity of *VHL* underlies the eponymous hereditary cancer syndrome. The *VHL* protein …
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Using Tissue Morphology to Infer Intra-Tumor Variation in Molecular State and Response
… These approaches are applied to two cancer types clear-cell renal cell carcinoma (ccRCC) and colorectal cancer (CRC). In ccRCC, we aim to understand the extent to which intra-tumor variation in key driver genes, BAP1, PBRM1, and SETD2, can be inferred purely from the analysis of histopathology …
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Prolyl Isomerase Pin1 Is a Conditional Tumor Suppressor
… function of numerous Pin1 substrates involved in cell cycle and tumorigenesis. During cell cycle progression, the timely synthesis and degradation of key regulatory proteins is required to maintain genomic integrity. Previously, we determined that Pin1 binds to and promotes the degradation of the …
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