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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Claudins"”.
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The Role of Claudins in Bone Metabolism
<p>Osteoporosis, a major public health problem in the U.S., is characterized by low bone mass and structural deterioration of bone tissue. Since the imbalance between bone formation and bone resorption during bone remodeling has been documented to be a major factor in the pathogenesis of …
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A Tale of Breast Cancer, Behavior and Brains as Affected by Diet and Claudins
North Carolina State University Theses Zoology.
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Claudins and tight junction-associated MARVEL proteins at the blood-brain barrier – contribution to paracellular barrier formation
Claudin (Cldn)-5 is thought to dominate the tight junctions (TJs) of the blood-brain barrier (BBB) with minor contribution of Cldn3, -12 and occludin (Ocln). However, in Cldn5 knockout mice the BBB appears ultrastructurally normal (Nitta et al., 2003). Therefore, the involvement of further Cldns …
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Direct and indirect interaction mechanisms of immune cells and tight junction proteins
… evidence that certain APCs express different claudins, immune cells transmigrate predominantly trough the tTJ. Therefore, the hypothesis was postulated that im-mune cells express (t)TJ proteins to interact with the tTJ to transmigrate through the paracel-lular space. To investigate this, …
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MOLECULAR PHYSIOLOGY OF BLOOD-BRAIN BARRIER TIGHT JUNCTIONS
… transmembrane domains affect the dimerization of claudins. Chapter 4 extends upon the discoveries from chapters 2 and 3 to other claudins that are relevant for the tight junction biology. There is an inherent need to compare different members of the claudin family of proteins to enhance the …
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Mechanistic insight into the role of dietary fibers and short chain fatty acids in the regulation of metabolism and inflammation in the pig
… from increased expression of tight junction claudins. Butyrate restored LPS-induced reduction in Akt and 4E-BP1 expression levels, accounting for its effect in enhancing tight junction intergrity. In addition, butyrate also acted as energy source fueling epithelial cell recovery, evidenced by …
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Regulation of COX-2 and PGE2-Dependent Recovery of Intestinal Barrier Function
… there were no changes in occludin or claudins-3 and -5. Immunoflourescence demonstrated that PGE2 increased accumulation of claudin-1 at the apical lateral membrane. Additionally, we showed that PGE2 increased tyrosine phosphorylation of claudin-1 within 30 min, an effect prevented by …
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Έκφραση των κλωντινών-1,4,5,7 και αποφραξίνης σε ασθενείς με ηπατοκυτταρικό καρκίνωμα και συσχέτιση αυτών με κλινικοπαθολογοανατομικούς παράγοντες και με την επιβίωση των ασθενών
Οι κλωντίνες και η αποφραξίνη αποτελούν δομικά συστατικά των πρωτεϊνών διακυτταρικών συνάψεων, οι οποίες αποδιοργανώνονται λειτουργικά σε διάφορα κακοήθη νεοπλάσματα, συμπεριλαμβανομένου και του ηπατοκυτταρικού καρκινώματος (ΗΚΚ). Σκοπός: Στην μελέτη μας, διερευνήσαμε το κατά πόσο είναι εφικτή η …