Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Claudin-low"”.
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NF-YA ISOFORMS ROLES IN CLAUDIN LOW CANCERS
… is highly expressed in all subtypes except in Claudinlow in which NF-YAl isoform is predominant. Recently it has been identified a 158 genes signature defining Claudinlow tumor subclass common to BRCA and STAD, correlating with high NF-YAl/NF-YAs ratio. For the first part of my PhD project, I …
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The role of NEDD9 in TGFβ mediated tumour initiating cell dynamics in the Claudin-low breast cancer subtype
… breast tumour-initiating cells (BTICs). In the claudin-low breast cancer subtype, TGFβ increases the tumour initiating capacity through the ability of the scaffolding protein NEDD9 to unite the TGFβ/SMAD and Rho-Actin-SRF pathways. Previously, oncogenicity has been ascribed to the level of NEDD9 …
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SILVER NANOPARTICLES ARE EFFECTIVE FOR THE TREATMENT OF CLAUDIN LOW BREAST CANCER AND OTHER MESENCHYMAL CANCERS WITH HIGH ZEB1 EXPRESSION
… luminal B, HER-2 overexpressing, basal-like, and claudin-low) that have distinct genetic aberrations, morphological features, prognoses, and therapeutic responses. Therefore, breast cancer should be treated with subtype specific therapies as these may provide the greatest therapeutic benefit.
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Define The Epigenetic Profiles and Subtype-Specific Genes of Breast Cancer
… A, luminal B, HER2-enriched, basal-like, and claudin-low breast cancer. These 5 subtypes correlate with hormone response, patient prognosis, and response to therapy. Although steady state gene expression patterns have been explored using expression microarrays, very little is known about the …
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Oncoproteomic applications for detection of breast cancer. Proteomic profiling of breast cancer models and biopsies
… luminal A, luminal B, HER2, basal-like and claudin-low, on the basis of a single gene or protein. Therefore, a collection of markers is required that can serve as a signature for diagnosing different types of breast cancer. New developments in proteomics have provided the opportunity to look …
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Transcriptional regulators in stem cell biology
… stemness and tumorigenesis. Furthermore, human claudin-low breast cancer cells form primary cilia, and sequencing experiments demonstrated that GLIS2 is inactive in claudin-low breast tumors, indicating that GLIS2 regulation is relevant to normal and transformed mammary cells. Collectively, this …
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Context Dependent Roles of MDMX (MDM4) and MDM2 in Breast Cancer Proliferation and Circulating Tumor Cells
… expressing MDA-MB-231 cells, which belong to claudin-low/TNBC subtype, inducible MDM2 knockdown reduced migration without changing cell proliferation. This indicates a context dependent role of MDM2 in breast cancer progression.<em> </em>Co-overexpression of <em>mdm2</em> and <em>mdmx </em>has …