Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"Claudin 1"”.
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Mitochondrial respiratory defects induces claudin 1 expression via ROS-mediated HSF1 activation
Claudin-1 (Cln-1) are tight junction components that have recently been reported to be involved in cancer metastasis. Interestingly, we found that SNU human hepatoma cells with mitochondrial dysfunction have high level of Cln-1 expression. In those HCC cells, Cln-1 played a key role in regulating …
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Charakterisierung der Funktion des Tight Junction Proteins hu-CLDN1 und seine Bedeutung bei der Tumorgenese
… wichtigsten Tight Junction Proteine, Claudin-1 und -2 in der Maus beschrieben. An Hand von Sequenzhomologien konnten bis heute dieser 4 Transmembrandomänen Proteinfamilie 18 Mitglieder mit unterschiedlichen Gewebeverteilungen zugeordnet werden. Parallel zum murinen Claudin-1 wurde von …
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Protektiver Effekt von 6-Shogaol, Ellagsäure und Myrrhe auf die intestinale epitheliale Barriere
… Proteinfamilie der Tight Junctions (TJs), der Claudine. Die Barrierefunktion wird durch Messung des transepithelialen Widerstands (TER) und der Fluxmessung in der Ussing-Kammer bestimmt. Dazu werden die HT-29/B6- und Caco-2-Monolayer mit den Pflanzenkomponenten (6-Shogaol, Ellagsäure, Myrrhe), …
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Defining the mechanism(s) of Hepatitis C virus (HCV) entry
… BI (SR-BI), and the tight junction (TJ) proteins Claudin-1 and Occludin. Primary HCV strains cannot be efficiently cultured in vitro, making the evaluation of potential antiviral compounds in a biologically relevant context extremely difficult. Despite being suitable for high-throughput screening, …
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Effect of Diabetes Mellitus on Ocular Surface Tight Junctions and Glycocalyx
… protein expression of tight junction proteins: claudin-1, claudin-2, claudin-3, ZO-1, ZO-2, ZO-3, and occludin was quantified using real time PCR and western blotting. Type I diabetes was induced in mice by streptozotocin injection. Phenol red thread test, fluorescein staining and wheat-germ …
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Schlussleisten (Zonulae occludentes) und biochemisch verwandte Strukturen: Tight Junction-Proteine und -Funktionen in mehrschichtigen Epithelien, mit besonderer Berücksichtigung der Plattenepithelmetaplasie
… TJ-Proteine wie z.B. Occludin oder bestimmte Claudine angereichert waren. Diese neuartigen TJ-Protein-Strukturen wurden daher als „Stud Junctions“ (Puncta occludentia) bezeichnet und mit anderen TJ-verwandten, Claudin- bzw. Occludin-haltigen interdesmosomalen Strukturen wie den „Lamellated …
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Defect of Mitochondrial Translation Machinery Enhances Hepatoma Cell Invasiveness
… induced by doxycycline in SNU-387 cells 20 5. Claudin-1 regulates Mt-TMD-induced hepatoma cell invasiveness. 26 6. Impact of doxycycline on gene expression 30 IV. DISCUSSION 33 V. CONCLUSION 36 REFFERENCE 37 국문요약 43
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Characterizing various aspects of the male genital tract barrier function and immunity
… in vivo Oral Pre-Exposure Prophylaxis (PrEP) on claudin-1 expression and lymphoid/myeloid cells in the foreskin (Published manuscript chapter) Methods Male volunteers who were undergoing VMMC were recruited from community clinics in Retreat, TC-Newman and Mitchells Plain, Western Cape. Multiplex …
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The role of scavenger receptor B-I in hepatitis C virus attachment and entry.
… CD81, Scavenger Receptor B-I (SR-BI) and Claudin-1. SR-BI is a receptor for high density lipoprotein (HDL), it is predominantly expressed in the liver and steroidogenic tissue. HCV is believed to interact with SR-BI via the viral envelope protein E2, interestingly the SR-BI ligand HDL …
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Placental co-culture model reveals Listeria monocytogenes utilization of monocytes for vertical transmission
… revealed severe disruption of occludin and claudin-1 tight junctions. This study demonstrates Listeria usage of the Trojan horse mechanism to reach and translocate the human placental barrier. Thus, Listeria infection can utilize both extracellular and intracellular forms of the pathogen to …
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Dissecting the Entry Pathways of Hepatitis C and Bovine Viral Diarrhea Viruses
… scavenger receptor class B type 1 (SR-BI), and claudin-1 (CLDN1), in mediating HCV entry and their modulation during persistent HCV replication were also investigated. This work highlights common features shared between BVDV and HCV and provides insight into the cellular environment required for …
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Einfluss des Flavonoids Quercetin auf die epitheliale Barrierefunktion der humanen Kolonkarzinom-Zelllinie Caco-2
… insbesondere durch die Proteine Occludin und die Claudine definiert. Ziel dieser Arbeit war es, die Effekte des am häufigsten vorkommenden Flavonoids Quercetin auf die Barrierefunktion der Kolonkarzinom-Zelllinie Caco-2 zu untersuchen. Hierbei zeigte sich, dass Quercetin konzentrationsabhängig …
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Molecular Analysis of Hepatitis C Virus Envelope Glycoprotein E2 Binding and Entry
… B type 1 (SR-B1). The critical incorporation of claudin-1 receptor (CLDN-1) and occludin receptor (OCLN) (indirect interaction) has been reported. Then, fusion process is intiated between viral and cellular membranes following acidification of endosomes. All known HCV-receptor interactions are …
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Characterizing Changes in the Brain During Hydrocephalic Development and Exploring Potential Treatment Strategies
… proteins expressed in choroid plexus (CP); claudin-1 (Cl-1) and zona occludin 1 (ZO-1) fluorescent intensity increased in P15 hydrocephalic animals compared to wildtype (Tmem67+/+). These cells also contain aquaporins (AQP), aquaporin-1 (AQP1) and aquaporin-4 (AQP4), important in regulating …
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Influence of infant milk formula processing on protein digestion and gut barrier health in vitro and in vivo
… the gut lumen, higher mRNA transcript levels of claudin-1 in the mucosal scrapings and higher lactase activity in brush border membrane vesicles compared to those pigs fed HT-IMF (P < 0.05). To further investigate these gut responses, in vitro gut barrier models were employed (i.e. polarised …
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Immunoprotective effects of lipopolysaccharide detoxification by a novel microbial-derived alkaline phosphatase
… ZO-1 and inflammation-induced increases in claudin-1. IAP is known to be downregulated post-weaning due to increased inflammatory mediators which inhibit gene expression. Therefore, we sought to determine the effects of exogenous MAP supplementation on endogenous IAP gene expression and …
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Inhibition of pancreatic cancer progression through EMT inhibition and induction of ER stress
… it increased the epithelial markers ZO-1 and Claudin-1. Findings from this first part of the study suggested that C150 is a novel EMT inhibitor with the potential of inhibiting pancreatic cancer growth and metastasis. The enhanced proteasome-mediated degradation of Snail by C150 intrigued our …
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Investigating Novel Inhibitors of Epithelial - Mesenchymal Transition (EMT) and Cancer Stem Cells (CSCs) in Pancreatic Cancer
… of EMT by upregulating epithelium marker Claudin-1 and downregulating mesenchymal marker Vimentin and Snail. Restoration of HuR in HuR deleted (KO) pancreatic cancer cells enhanced migration and enriched CSC population. RNP-IP assay and dual-luciferase reporter assay identified that SNAI1 …
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Roles of Neutrophil Activation in Asthma
… and tight junction protein (occludin and claudin-1) expression levels in airway epithelial cells (AECs) were evaluated by CCK8 assay and Western blot analysis. Peripheral blood eosinophils (PBEs) were isolated from peripheral blood of human donors using MACS system. Secretion levels of …