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Showing 1 to 20 of 56 for “"Claudin"”.

  1. Computational Modeling of Claudin-15 Paracellular Channels

    Sarah McGuinness (24399449)2026

    … permeability in epithelial tissues through claudin protein assemblies, yet the molecular basis of strand flexibility, pore architecture, and ion selectivity for cation-selective claudin-15 (Cldn-15) remains incompletely defined at atomic resolution. This dissertation employs molecular …

    uic

  2. NF-YA ISOFORMS ROLES IN CLAUDIN LOW CANCERS

    LONDERO, MICHELAUniversità degli Studi di Milano2024

    … is highly expressed in all subtypes except in Claudinlow in which NF-YAl isoform is predominant. Recently it has been identified a 158 genes signature defining Claudinlow tumor subclass common to BRCA and STAD, correlating with high NF-YAl/NF-YAs ratio. For the first part of my PhD project, I …

    milano Repository record

  3. The Hormonal Regulation of the Claudin Genes in the Ovary

    Gadson, Sean, Binder, April, Korach, Kenneth, Hamilton, Katherine2019

    … in the ovary and disrupt ovarian function. The Claudin (<em>Cldn</em>) 3 and <em>Cldn11</em> genes have been shown to be regulated by androgens in the testis, while studies in ovarian cancer cells suggests a coregulatory mechanism for the expressions of <em>Cldn3</em> and <em>Cldn4</em> in the …

    central-wash Repository record

  4. Mitochondrial respiratory defects induces claudin 1 expression via ROS-mediated HSF1 activation

    이, 종혁2014

    Claudin-1 (Cln-1) are tight junction components that have recently been reported to be involved in cancer metastasis. Interestingly, we found that SNU human hepatoma cells with mitochondrial dysfunction have high level of Cln-1 expression. In those HCC cells, Cln-1 played a key role in regulating …

    ajou Repository record

  5. The role of NEDD9 in TGFβ mediated tumour initiating cell dynamics in the Claudin-low breast cancer subtype

    Greenwood, WendyUniversity of Cambridge2021

    … breast tumour-initiating cells (BTICs). In the claudin-low breast cancer subtype, TGFβ increases the tumour initiating capacity through the ability of the scaffolding protein NEDD9 to unite the TGFβ/SMAD and Rho-Actin-SRF pathways. Previously, oncogenicity has been ascribed to the level of NEDD9 …

    cambridge Repository record

  6. SILVER NANOPARTICLES ARE EFFECTIVE FOR THE TREATMENT OF CLAUDIN LOW BREAST CANCER AND OTHER MESENCHYMAL CANCERS WITH HIGH ZEB1 EXPRESSION

    Swanner, Jessica LynnWake Forest University2017

    … luminal B, HER-2 overexpressing, basal-like, and claudin-low) that have distinct genetic aberrations, morphological features, prognoses, and therapeutic responses. Therefore, breast cancer should be treated with subtype specific therapies as these may provide the greatest therapeutic benefit.

    wfu Repository record

  7. Protektiver Effekt von 6-Shogaol, Ellagsäure und Myrrhe auf die intestinale epitheliale Barriere

    Lüttig, JuliaUniversität Potsdam

    … Proteinfamilie der Tight Junctions (TJs), der Claudine. Die Barrierefunktion wird durch Messung des transepithelialen Widerstands (TER) und der Fluxmessung in der Ussing-Kammer bestimmt. Dazu werden die HT-29/B6- und Caco-2-Monolayer mit den Pflanzenkomponenten (6-Shogaol, Ellagsäure, Myrrhe), …

    potsdam-diss Repository record

  8. MOLECULAR PHYSIOLOGY OF BLOOD-BRAIN BARRIER TIGHT JUNCTIONS

    Irudayanathan, Flaviyan Jerome

    … aspects of the pores that are feasible under claudin-5 tight junction assembly. We performed a mutation experiment that distinguished the dimeric interfaces between claudin-3 and claudin-5, further a biophysical investigation showed how the flexibility of the transmembrane domains affect the …

    syracuse-diss Repository record

  9. Einfluss des Flavonoids Quercetin auf die epitheliale Barrierefunktion der humanen Kolonkarzinom-Zelllinie Caco-2

    Schlichter, SusanneUniversität Potsdam

    … insbesondere durch die Proteine Occludin und die Claudine definiert. Ziel dieser Arbeit war es, die Effekte des am häufigsten vorkommenden Flavonoids Quercetin auf die Barrierefunktion der Kolonkarzinom-Zelllinie Caco-2 zu untersuchen. Hierbei zeigte sich, dass Quercetin konzentrationsabhängig …

    potsdam-diss Repository record

  10. Schlussleisten (Zonulae occludentes) und biochemisch verwandte Strukturen: Tight Junction-Proteine und -Funktionen in mehrschichtigen Epithelien, mit besonderer Berücksichtigung der Plattenepithelmetaplasie

    Schlüter, HolgerUniversität Heidelberg

    … TJ-Proteine wie z.B. Occludin oder bestimmte Claudine angereichert waren. Diese neuartigen TJ-Protein-Strukturen wurden daher als „Stud Junctions“ (Puncta occludentia) bezeichnet und mit anderen TJ-verwandten, Claudin- bzw. Occludin-haltigen interdesmosomalen Strukturen wie den „Lamellated …

    heid-diss Repository record

  11. The Effects of Onion and Yuzu Extracts against Ischemia/Hypoxia-Induced Dysfunction of Blood-Brain Barrier

    현, 수왕2015

    … of ZO-1 and FoxO3a-mediated degradation of claudin-5 during ischemia/hypoxia using the mouse middle cerebral artery occlusion (MCAO) model and hypoxia model. The possible underlying mechanisms are also investigated, especially those linked to the oxidative stresses. Onion extract (OE) and …

    ajou Repository record

  12. Effect of Diabetes Mellitus on Ocular Surface Tight Junctions and Glycocalyx

    Alfuraih, Saleh M2022

    … protein expression of tight junction proteins: claudin-1, claudin-2, claudin-3, ZO-1, ZO-2, ZO-3, and occludin was quantified using real time PCR and western blotting. Type I diabetes was induced in mice by streptozotocin injection. Phenol red thread test, fluorescein staining and wheat-germ …

    chapman Repository record

  13. A Role for Fenugreek in Altering the Osmoregulatory Capacity in Rainbow Trout (Oncorhynchus Mykiss)

    Mckee, Sean Dylan2015

    … decreased. Fenugreek resulted in an increase in claudin-7 and -30, and a decrease in claudin-33b. While it was demonstrated that fenugreek can impact salt-water balance, and affect changes similar to freshwater acclimation, it is unlikely that these changes were brought about via prolactin.

    york Repository record

  14. Define The Epigenetic Profiles and Subtype-Specific Genes of Breast Cancer

    Li, Wenqian2017

    … A, luminal B, HER2-enriched, basal-like, and claudin-low breast cancer. These 5 subtypes correlate with hormone response, patient prognosis, and response to therapy. Although steady state gene expression patterns have been explored using expression microarrays, very little is known about the …

    uthsc Repository record

  15. Charakterisierung der Funktion des Tight Junction Proteins hu-CLDN1 und seine Bedeutung bei der Tumorgenese

    Hövel, ThorstenUniversität Würzburg

    … wichtigsten Tight Junction Proteine, Claudin-1 und -2 in der Maus beschrieben. An Hand von Sequenzhomologien konnten bis heute dieser 4 Transmembrandomänen Proteinfamilie 18 Mitglieder mit unterschiedlichen Gewebeverteilungen zugeordnet werden. Parallel zum murinen Claudin-1 wurde von …

    wurz-thes Repository record

  16. The effects of ethanol and aspalathus linearis on immortalized mouse brain endothelial cells (bEnd5)

    Thomas, Kelly AngeliqueUniversity of the Western Cape2015

    … rate of cell division (iv) cell toxicity (v) claudin-5 transcription (vi) permeability across a monolayer of bEnd5 ECs and (vii) morphology, for a selected experimental timeline of 24, 48, 72, and 96hrs. We then investigated if the simultaneous exposure of Rf and EtOH could reverse or …

    western-cape Repository record

  17. Defining the mechanism(s) of Hepatitis C virus (HCV) entry

    Schwarz, Anne-KatrinUniversity of Birmingham2009

    … BI (SR-BI), and the tight junction (TJ) proteins Claudin-1 and Occludin. Primary HCV strains cannot be efficiently cultured in vitro, making the evaluation of potential antiviral compounds in a biologically relevant context extremely difficult. Despite being suitable for high-throughput screening, …

    birmingham Repository record

  18. Oncoproteomic applications for detection of breast cancer. Proteomic profiling of breast cancer models and biopsies

    Shaheed, Sadr-ulUniversity of Bradford2017

    … luminal A, luminal B, HER2, basal-like and claudin-low, on the basis of a single gene or protein. Therefore, a collection of markers is required that can serve as a signature for diagnosing different types of breast cancer. New developments in proteomics have provided the opportunity to look …

    bradford Repository record

  19. Coregulatory Transcription Factors and Spermatogenesis

    Morrow, Carla K.University of Illinois at Urbana-Champaign2015

    … in Etv5 -/- mice, and that this was mediated by Claudin 5 (CLD5). In both Etv5-/- and W/Wnu mice, the BTB was leaky. Examination of CLD5 expression among mice of various ages and phenotypes revealed the following: both ETV5 and germ cells were necessary for seminiferous epithelial CLD5 …

    uiuc Repository record

  20. Characterizing various aspects of the male genital tract barrier function and immunity

    Rametse, CosnetDepartment of Clinical Laboratory Sciences2024

    … in vivo Oral Pre-Exposure Prophylaxis (PrEP) on claudin-1 expression and lymphoid/myeloid cells in the foreskin (Published manuscript chapter) Methods Male volunteers who were undergoing VMMC were recruited from community clinics in Retreat, TC-Newman and Mitchells Plain, Western Cape. Multiplex …

    cape-town Repository record

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