Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 110 for “"Clathrin"”.
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Yeast Dynamin Functions with Clathrin at the Golgi
… dynamin family proteins work in concert with clathrin to facilitate not only receptor-mediated endocytosis, but also traffic from the Golgi to endosomes. In this study, the interdependency between Vps1 and clathrin was investigated. Subcellular localization of clathrin was at the Golgi, early …
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Regulation of Clathrin Mediated Endocytosis and Its Role in Cancer Progression
… to measure three different endocytic pathways: clathrin-mediated endocytosis, caveolae-mediated endocytosis, and clathrin-independent endocytosis and compared these activities in 29 independently isolated non-small cell lung cancer (NSCLC) cell lines to determine whether there were systematic …
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Conserved and Novel Properties of Clathrin-Mediated Endocytosis in Dictyostelium Discoideum
<p>The protein clathrin mediates one of the major pathways of endocytosis from the extracellular milieu and plasma membrane. Clathrin functions with a network of interacting accessory proteins, one of which is the adaptor complex AP-2, to co-ordinate vesicle formation. Disruption of genes involved …
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σ1-adaptin - the Small Subunit of the Clathrin Adaptor Complex AP-1
… Proteinkomplex, der an der Bildung von Clathrin-Vesikeln am trans-Golgi Netzwerk und an Endosomen mitwirkt. Durch die Bindung an Phosphatidylinositol-4-phosphat, an ARF-1 und an Sortierungssignale der transportierten Proteine gelangt der Komplex an die Membran. AP-1 selbst bindet …
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PI(4)P-Dependent Recruitment of Clathrin Adaptors to the Trans-Golgi Network
… 4 phosphate [PI(4)P] and that the clathrin adaptor AP-1 binds PI(4)P directly, suggesting that PI(4)P binding may specify the TGN-specific recruitment in conjunction with Arf1. My studies showed that another monomeric clathrin adaptor GGA also binds PI(4)P and Arf1 independently. …
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REGULATION AND PHYSIOLOGICAL ROLE OF NON-CLATHRIN ENDOCYTOSIS OF THE EPIDERMAL GROWTH FACTOR RECEPTOR
… a novel endocytic route of the EGFR, non-clathrin endocytosis (NCE), which is activated only after stimulation with high doses of the ligand epidermal growth factor (EGF). Unlike canonical clathrin-mediated endocytosis (CME) that directs receptor mainly to recycling, NCE leads mostly to …
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Recognition of basic sorting motifs within synaptic membrane cargo proteins by the clathrin-adaptor complex AP-2
… von synaptischen Proteinen mittels clathrin-umhüllter Vesikel spielt eine wichtige Rolle in der Regulierung von Prozessen an beiden synaptischen Seiten. An der Präsynapse werden synaptische Vesikel Proteine und überschüssige Membran durch Clathrin-vermittelte Endozytose …
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The rickettsial effector Sca4 has a conserved interaction with host clathrin and a tick cell specific role in infection
… Sca4 interacts with the host endocytic factor clathrin heavy chain. As previous work showed that Sca4 interacts with the host protein vinculin in mammalian cells, this discovery of the Sca4-clathrin interaction makes Sca4 one of the first multifunctional effectors to be identified in a …
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Distribution and targeting of CLC-3
… compartments. ClC-3 was associated with clathrin at the plasma membrane and in early endocytic vesicles. It also colocalized with transferrin-labelled endosomes. It dissociated from clathrin at later times to localize in large vesicles. GST pull-down assays demonstrated that the …
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Characterisation of the AP-3 adaptor-like complex
Clathrin coated vesicles were the first type of coated vesicle to be characterised. The coat consists of two components, clathrin and adaptor (or AP) complexes, the AP-1 complex is associated with the clathrin coated vesicles that bud from the TGN and the AP-2 complex is associated with the …
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Genetic analysis of stoned B/stonin 2 function in vivo
Clathrin-vermittelte Endozytose an der prä-synaptischen Membran ist ein regulierter Vorgang, der streng an die Exozytose synaptischer Vesikel gekoppelt ist und u. a. von Clathrin, Dynamin, AP2 und Synaptotagmin 1 abhängig ist. Stonin 2 ist ein Protein, das in Hirngewebe angereichert vorgefunden …
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Effect of uptake pathway on non-viral gene delivery in vitro and in vivo
… we have investigated the effects of clathrin-dependent endocytosis and caveolin-dependent endocytosis on the efficacy of PEI and PEI-derivative gene delivery in HeLa and MDA-MB-231 cell cultures and xenograft tumors. First, we attached transferrin and folate ligands to PEI to direct …
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The Effect of Endocytosis of Interferon-lambda and The Genotype of IL-10RB on The Cellular Responses to Cytokines
… 신호전달과 기능에 관련되므로 중요하게 연구 되고있다. Endocytosis는 크게 clathrin-dependent/-independent, caveolae-dependent /-independent pathway와 그 외의 다른 pathway들로 분류 된다. 또한 dynamin II 관련에 의해 endocytosis 경로가 세분화된다. Interferon (IFN)은 type I, type II, 그리고 type III의 세 그룹으로 분류되며, Interferon lambda는 IFN-1, IFN-2, IFN-3로 …
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Zelluläre Aufnahme und intrazelluläres Schicksal von partikulären Drug Delivery Systemen
… Trafficking bestimmt. Neben der "klassischen" Clathrin-vermittelten Endozytose existieren verschiedene Wege für die partikuläre Aufnahme in die Zelle, wie Phagocytose, Makropinocytose, Caveolae-vermittelte Endozytose und so genannte Non-Clathrin-non-Caveolae vermittelte Endozytose. Von diesen …
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cpg2 encodes a brain- and synapse-specific protein that regulates the endocytosis of glutamate receptors
… of excitatory synapses, often in the vicinity of clathrin-coated pits. I further show that, through its C-terminal coiled-coil motifs, CPG2 binds to the actin cytoskeleton and to endophilin B2, a member of a family of proteins involved in membrane trafficking. RNAi-mediated knock-down of CPG2 …
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Overcoming the plasma membrane barrier to improve the efficiency of therapeutic delivery to the cellular cytoplasm
… understanding of the mechanisms that drive clathrin-mediated endocytosis, I then investigated the curvature sensing abilities of clathrin, a critical question limiting our understanding of how nanoparticles and other molecular cargo are internalized. In particular, my findings demonstrate …
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Funktionelle Charakterisierung und ultrastrukturelle Lokalisierung der Isotypen des Hüllprotein-Komplexes Coatomer
… bei den a/b-Adaptinen, Bestandteile der Clathrin-Adaptorkomplexe (APs), identifiziert. Neben Aminosäuresequenz-Vergleichen zwischen AP-Komplexen und dem b/d/g/z-COPI Subkomplex (Schledzewski et al. 1999), der unter nicht physiologischen Salz-Bedingungen vom a/b’/e-COPI Subkomplex …
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Phosphorylation sites on specific neuronal proteins can control the mode of synaptic vesicle exocytosis and thereby regulate synaptic transmission
… This dynamin-dependent KR mode is independent of clathrin because this is not perturbed by the blockade of clathrin action using the drug, pitstop2TM and the HK5C evoked myosin-II-dependent KR is independent of both clathrin and dynamin. Therefore, the KR mechanism described, herein, is distinct …
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Odorant receptors: regulation, signaling, and expression
… complex, and targeting of this moiety to clathrin-coated pits. Dynamin initiates the formation of an endocytic vesicle from the clathrin-coated pit. Data are presented that identify and localize dynamin and clathrin to the dendritic extension of olfactory receptors where olfactory signal …
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