Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Class I PI3K"”.
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The role of PTEN as a PI(3,4)P2 lipid phosphatase in Class I phosphoinositide 3-kinase signalling
… role of PTEN as a PI(3,4)P2 lipid phosphatase in Class I phosphoinositide 3-kinase signalling Abstract Class I phosphoinositide 3-kinases (Class I PI3Ks) are essential players involved in the signalling events in the cell and are critical promoters of cellular growth, survival and metabolism. Once …
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SGK3 activity and regulation in PI3K-Akt pathway inhibitor resistance in breast cancer
The PI3K-Akt signalling pathway is central to cell proliferation and growth, and hyperactivating mutations in this pathway are found in a large number of cancers. Downstream of PI3K, Akt is heavily studied, however the highly related SGK family of protein kinases have recently been identified as …
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A dissection of class I phosphoinositide 3-kinase signalling in mouse embryonic fibroblasts and prostate organoids
Class I PI3Ks are a family (α, β, δ and γ) of ubiquitous lipid kinases that can be activated by cell surface receptors to 3-phosphorylate PI(4,5)P2 (phosphatidylinositol(4,5)-bisphosphate) and generate the signalling lipid PI(3,4,5)P3. The PI(3,4,5)P3 signal then activates a diverse collection of …
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Pi3K- and Mtor-Dependent Mechanisms of Lapatinib Resistance and Resulting Therapeutic Opportunities
… resistance. We found that activation of PI3K, specifically the p110α catalytic subunit, was enhanced in two out of three LapR cell lines, through p110α activating mutations and/or upregulation. In a third LapR cell line, mTOR activation was enhanced in a manner independent of its usual …
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DNA Damage-dependent Regulation and Function of akt-1 in Caenorhabditis elegans
… single, conserved phosphatidylinositol 3-kinase (PI3K) signaling pathway that regulates somatic developmental decisions and lifespan through the Insulin-like receptor tyrosine kinase (RTK) DAF-2, the class I PI3K AGE-1 and the 3-phosphoinositide-dependent protein kinase 1 (PDK1) homologue PDK-1. …
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Genome-wide cross-cancer analysis reveals the importance of bimodal microRNA in predicting patient survival and drug response
… for genes in the phosphoinositide-3-kinase (PI3K) pathway, and a survey of over 200 cancer drugs found that cell lines with high miR-105 and miR-767 levels responded best to drugs targeting the same pathway. To mimic high miR-105 and miR-767-expressing tumors, the two miRNA were overexpressed …
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DISSECTING THE FUNCTION AND INTERACTOME OF PLEKHS1 IN PROSTATE TUMORIGENESIS
… the lipid product and key signalling output of Class I phosphoinositide 3-kinases (PI3Ks) and acts as a coordinator of a huge network that controls cellular processes such as metabolism, cell growth and movement. Mutations that augment the activity of this network are amongst the most common …