Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 36 for “"Clamps"”.
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Mitigation of simultaneous switching noise by active rail clamps
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2025-10-20 without embargo terms
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Nucleic acid clamp-mediated transcriptional and translational modulation of oncogenes via the stabilization of G-quadruplexes
… expression. In this body of work, we designed clamps specific for both the MYC promoter G4 and the NRAS 5’-UTR G4. we examined the binding specificity and G4 stabilizing capability of the designed clamps to their corresponding target using electromobility shift assay, electronic circular …
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Synthesis towards synthetic adenosine receptor
… Multistep synthesis was done to synthesize two clamps, namely the [pi]-[pi] stacking clamp and the hydrogen bonding clamp for the proposed tweezer. These two clamps in coordination with Zn^{+2} ions intended to form a pre-organized tweezers molecule for more favorable complexation with adenosine.
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Systemic Insulin Sensitivity and Skeletal Muscle Akt Signaling in Rats Artificially Selected for Low and High Aerobic Capacity
… (n=7 per group). Euglycemic-hyperinsulinemic clamps on catheterized rats tested insulin sensitivity while sham LCR and HCR were used for basal tissue analysis. Plasma insulin levels did not differ during the clamps, but LCR required lower glucose infusion rates than HCR (p<0.05). Upon insulin …
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A kinematic coupling based 6 degrees of freedom dynamometer
… a three groove kinematic coupling. Three toggle clamps are used to preload the machine, so that it does not come apart. The device was designed, analyzed, built and tested. The error will mainly depend on frictional forces, load cells error and the toggle clamps. Frictional forces affect …
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The Roles of Free Fatty Acids and Inflammation in β-Cell Dysfunction
… fat infusion in mice followed by hyperglycemic clamps or islet secretion studies ex vivo, and in vitro models of 48h exposure to oleate and palmitate in islets. The first study showed the proinflammatory kinase IKKβ is causally involved in fat-induced β-cell dysfunction during hyperglycemic …
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Structural Studies of DNA Replication Proteins by X-Ray Crystallography and Molecular Dynamics
… simulations were performed on the sliding clamps from Escherichia coli and Streptococcus pyogenes. The studies demonstrated that one subunit of the dimeric clamp, when the other subunit is absent, would relax to a structure of reduced curvature ("open" state) when compared to its structure …
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Design of clamping mechanism for securing sections of unmanned submarine
… sections. An angled interface between the clamps and the sections, with an angle of 250, transmits the clamp tension into axial tension, which pulls the sections together and apply force on the gaskets and bulkhead that divides them. Within this paper, the design requirements and details …
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Comparative Studies of Processivity Clamp Loader ATP Site Function
<p>DNA replicases utilize ring-shaped sliding clamps to ensure polymerase processivity. An ATP-dependent clamp loader topologically links the clamp around DNA in a multi-step mechanism. Clamp loaders are ring-shaped pentamers of AAA+ subunits. The pentamer complex contains 3-4 ATP sites, each …
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The Kinematics of Rigid Body Contact in the Design and Analysis of Machining Fixtures
… both the optimal positions and forces of the clamps. For cylindrical faces we show a solution based on a nonlinear convex program. Next, we show a new linear algebraic method for computing the dependent and independent regions of form closure of a workpart. The former are regions where the …
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The molecular, hormonal and symptomatic responses to hypoglycaemia in mice
… test this hypothesis, I used hyperinsulinaemic clamps to create carefully controlled experimental manipulations of blood glucose. It is well established that the hypothalamus plays a fundamental role in glucose sensing and coordination of the concerted effort to maintain blood glucose within a …
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Energy efficiency of non-face brick production with particular reference to the drying process
… present all non-face plaster bricks are fired in clamps and only a few factories use dryers. Hollow ware rather than solid bricks find favour in South America, Asia and Europe, with the exceptions of the United Kingdom and the Netherlands, (the Netherlands use the soft mud process which does not …
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Characterization, Design, and Modeling of on -Chip Electrostatic Discharge Protection Devices
… techniques of RC-triggered, MOSFET based power clamps are discussed. A compact, timed-shutoff power clamp is proposed for area reduction and performance improvement.
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Improving a Low-Cost Intravenous Infusion Flow Rate Monitoring Device for Paediatric Care in Humanitarian Healthcare Settings
… being reliant on manual counting or mechanical clamps without safeguards. This particularly poses risks to the health outcomes of paediatric patients. This work builds upon the previous development of a low-cost flow rate monitor. An improved electrical design using open source software tools …
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A numerical study of the response of blast loaded thin circular plates, with both clamped and integral boundary conditions
… and a simple friction condition between the clamps and the plate surface. The inclusion of fillet radii at the integral boundary, and an edge radius at the clamped boundary, have been reported in additional experiments. These modifications are also modelled in the current investigation. The …
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Genetische und metabolische Regulation von Adiponectin : Resultate von in vitro und humanen in vivo Studien
… von hyperinsulinämischen euglykämischen Clamps führte eine akute Hyperinsulinämie zu einer Abnahme der Adiponectinspiegel. Adiponectin zirkuliert im Serum als hochmolekulare (HMW), mittelmolekulare (MMW) und niedrigmolekulare (LMW) Spezies. Mit zunehmendem Körpergewicht konnte eine …
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A clamp ligation method for point mutational spectrometry : marked increase in scanning range for the human genome
… was analyzed using both the natural and ligated clamps. A sensitivity of 2 x 10-5 in human cells was demonstrated using the ligated clamp as opposed to 5 x 10-6 using the natural clamp.
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MOBILITY ANALYSIS AND TOPOLOGY SYNTHESIS OF COMPLIANT MECHANISM USING COMPLIANCE NUMBER AND PSEUDO-RIGID-BODY MODEL (PRBM)
… concepts for constant-force-based surgical clamps and retractors to minimize tissue trauma during surgical procedures, caused by the application of excessive tool-tissue interaction forces"--Abstract, p. iii</p>
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The role of brown adipose tissue on substrate metabolism and insulin sensitivity in humans
… isotopic tracers, hyperinsulinemic-euglycemic clamps, indirect calorimetry, and positron emission tomography-computed tomography. A novel method was established to sample the supraclavicular BAT depot and white adipose tissue biopsies were collected from the subcutaneous abdominal area. During …
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Surface characterization of LDEF materials
… characterization of anodized aluminum tray clamps, which were located at regular intervals over the entire LDEF frame, has provided the first results to evaluate the extent of contamination with respect to position on the LDEF. The XPS results clearly showed that the amount and state of both …
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