Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"Citrullination"”.
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The role of citrullination of central nervous system proteins in multiple sclerosis.
… (MBP) and other CNS-specific proteins, including citrullination of arginine residues, results in conformational changes in the protein. This leads to increased degradation by proteases and exposure of new epitopes, which may then cause the production of autoantibodies targeting the myelin sheath. …
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An investigation of Porphyromonas gingivalis peptidylarginine deiminase: a putative virulence factor in an animal model of inflammation.
… and arginine-containing peptides. The rates of citrullination of enolase, vimentin and fibrin by P. gingivalis cells were calculated. The influence of the gingipains on citrullination was measured by comparing the rate of citrullination of albumin in the presence and absence of the proteolytic …
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Characterisation of HP1γ in mammalian cells
… cells. Mass spectrometry analysis identified citrullination of residues R38 and R39 within the CD of HP1γ. I show that these residues are citrullinated by peptidyl arginine deiminase 4 (PADI4) in vitro and in vivo. Mutations in HP1γ (R38/9A), designed to mimic the loss of charge accompanied …
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The role of Human Endogenous Retrovirus K10 (HERV-K10) in the pathogenesis of rheumatoid arthritis via molecular mimicry
… Fc and HERV. We further explored how protein citrullination affects the cross-reactivity of autoantibody responses in RA. These experiments revealed that generation of neoepitopes through citrullination of HERV-K10 and autoantigens IgG1 Fc and fibrinogen enhanced the reactivity of RA sera to …
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Identification of Roles for Peptidylarginine Deiminases (PADs) In Models of Nervous System Regeneration, Assessing Capacities of Pharmacological PAD Inhibitor Application
… five isozymes (PAD1,2,3,4 and PAD6) performing citrullination (deimination) with distinct tissue localisation and target preferences. They are implicated in various inflammatory conditions, including those affecting the central nervous system (CNS). Although PAD2 and PAD4 are currently …
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Presentation Of Citrullinated Peptides Derived From Unmodified Protein By Antigen Presenting Cells.
… proteins is established or the biology of citrullination by cells of the immune system. We find that immunization of B10.BR mice with HEL in CFA gives rise to T cells that specifically recognize citrullinated epitopes. We generated T cell hybridomas by fusing these T cells. T cell …
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Characterising the Role of the Calcium-dependent Citrullinating Enzyme Peptidyl Arginine Deiminase 2 in Ovarian Cancer
… (34%) and autophagy (38%), in a Ca2+- and citrullination-dependent manner, at 72 hours. PADI2 overexpression also induced cisplatin cytotoxicity by 10% at 72 hours. In ID8-Luc2 cells, PADI2 overexpression significantly decreased cisplatin cytotoxicity by 24%, independently of exogenous Ca2+ …
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LL-37 and citrullinated LL-37: differential modulation of the oxylipin - chemokine axis
… LL-37 and oxylipins, and how that is altered by citrullination, in the context of airway inflammation. In this study, a lipidomics analysis was performed to profile oxylipins enhanced in the presence of LL-37 and citrullinated LL-37 (citLL-37) in in human bronchial epithelial cells (HBEC). …
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Kinetic Characterization of the Protein Arginine Deiminase Family: Mechanistic and Inhibition Studies
… PAD4 inhibitors in an effort to reduce protein citrullination in the joints as a potential RA therapeutic. Recently, the design and synthesis of PAD4 inhibitors, F- and Cl-amidine, has been described. Herein, we have characterized the catalytic mechanisms of PADs 1, 3, and 4 by kinetic analysis …
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Early and late events in NET formation
… incomplete. In this work, we report that histone citrullination (as determined by immunoblot) is an immediate-early event in NET generation (<5 min), that is under the control of the p38, MEK, and TAK1 signaling pathways, which govern the early phase of NET generation. Conversely, chromatin …
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Investigating the pathways involved in the progression of fibrosis in tuberculous pericarditis
… whether the post-translational modification citrullination is involved in autoantibody production. Thirteen autoantibodies were expressed in the TBP pericardial fluid samples. The levels of leucine-rich repeat flightless-interacting protein 2 (LRRFIP2) were increased in TBP samples compared …
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Vitamin D Inhibits Expression of Protein Arginine Deiminase 2 and 4 in Experimental Autoimmune Encephalomoyelitis Model Of Multiple Sclerosis
Multiple sclerosis (MS) is a disabling disease that afflicts an estimated two million people worldwide. The disease is characterized by degradation of the myelin sheath that insulates neurons of the central nervous system manifesting as a heterogeneous collection of symptoms. Two enzymes, protein …
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THE PHD FINGER OF SP140: A STRUCTURAL AND FUNCTIONAL STUDY
… (acetylation, methylation, phosphorylation and citrullination). Taken together these data suggest that Sp140 PHD finger is not a classical epigenetic reader and other functions might be attributed to this domain, such as a SUMO E3 ligase activity towards the adjacent bromodomain. This hypothesis …