Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"Citrobacter rodentium"”.
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Studies on Citrobacter rodentium-enhanced colonic turmorigenesis in mice
Thesis (Ph. D.)--Massachusetts Institute of Technology, Division of Toxicology, 1996.
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Regulation of Host Immune Responses by Toll-Interacting Protein During Citrobacter rodentium Infection
… Escherichia coli (EPEC and EHEC). Citrobacter rodentium (CR), a murine A/E pathogen, mimics EPEC and EHEC infections, causing goblet cell depletion, crypt hyperplasia, and leukocyte infiltration into the colonic mucosa. Epithelial cells and innate immune cells detect CR through TLR …
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Citrobacter rodentium induced liver changes in C57BL/6 mice : animal model of acute inflammatory stress and injury
… composition and functions of the liver. Using Citrobacter rodentium, a well characterized rodent-specific enteric pathogen as a source of extrahepatic inflammatory stress; host liver responses, metabolic dysregulation, and susceptibility to injury in C57BL/6 mice were investigated. For the …
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Immunomodulation by subclinical persistent infection with Helicobacter hepaticus
… exposures, vaccines, as well as therapeutics. Citrobacter rodentium is a well-characterized model of infectious colitis with particular usefulness for modeling human diarrheal disease or inflammatory bowel disease. Infection with Helicobacter hepaticus is subclinical and persistent in C57BL/6 …
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Development, characterization and transcriptional profiling of a mouse model of fatal infectious diarrhea and colitis
Citrobacter rodentium is a naturally occurring murine bacterial pathogen which is used to model human diarrheagenic E. coli (EPEC and EHEC) infections in mice. C. rodentium causes colonic hyperplasia and a variable degree of colitis and mortality in the majority of inbred and outbred lines of mice. …
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Intestinal cancer : linking infection, inflammation and neoplasia
… analysis model was used to study infection with Citrobacter rodentium, an enteric bacterium that causes self-limiting hyperplasia and inflammation. Increased mutant frequency was observed in association with elevated levels of iNOS 13 days post infection. The second aim, to characterize a novel …
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The role of the inositol phosphatase, SHIP, in the innate immune response to Salmonella Typhimurium
… explored. ship⁻/⁻ mice were not susceptible to Citrobacter rodentium infection, yet developed severe inflammation of the ileum upon infection with this bacterium, with Salmonella, or when challenged orally with LPS. Increased collagen deposition was also observed at early time points …
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The Role of Host Hormones and Metabolites in the Regulation of Virulence in Enterohemorrhagic Escherichia coli (EHEC)
… human hormone, serotonin is sensed by EHEC, Citrobacter rodentium and uropathogenic E.coli. In EHEC and C.rodentium we showed that serotonin inhibits the transcription of the LEE PI. We also determined that the mechanism of LEE PI inhibition by serotonin is through the reduction of …
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Neutrophil localization during C. rodentium-induced colitis
… enteropathogenic colonization further, a murine Citrobacter rodentium (C. rodentium) model is used in this project to understand the activity of neutrophils, often the first cell line of defense, during infection. While it is known that neutrophils are involved in the eradication of C. rodentium, …
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Protein glycosylation by NleB and the secretion of therapeutic nanobody fusions
… FklB were not confirmed to be glycosylated in Citrobacter rodentium, S. enterica, enteropathogenic E. coli (EPEC), or enterohemorrhagic E. coli (EHEC). This could be due to the MinC and FklB bacterial proteins being false positives when the mass spectrometry experiments were completed. Despite …
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Small molecule inhibitors against enteric bacterial glycosyltransferases
… Escherichia coli, Salmonella enterica, and Citrobacter rodentium. T3SS resembles a molecular syringe structure to inject secreted effector proteins directly from the bacterial cell into the host cell. Our goal is to look for anti-bacterial virulence therapies by targeting important T3SS …
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Interplay Between Tryptophan Metabolites and the Virulence Factors of Enteric Pathogens
… E. coli (EHEC) and the mouse pathogen Citrobacter rodentium. We used multiple strategies including genetic manipulation, pharmacological inhibitors, and knock-out murine models to show that both indole and serotonin are inhibitory signals for virulence gene expression in EHEC and C. …
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Characterisation of bacteriophage dynamics associated with foodborne pathogens
… a new Listeria phage genus, Aquingentivirus. A Citrobacter rodentium mouse infection model was used to study the impact of phage treatment in vivo. C. rodentium is a widely used model for human enteropathogenic and enterohaemorrhagic E. coli. Interestingly, phage administration in vivo did not …