Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 308 for “"Cisplatin"”.
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Cannabinoid Modulation Of Cisplatin Induced Neuropathy
… or preventing tactile allodynia associated with cisplatin-administration. Mice (c57bl/6) were given eight doses of 2.3 mg/kg cisplatin or saline solution ip every second day to induce tactile allodynia (ringers on alternate days). Tactile responses to hind-paws were quantified in g of force using …
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Mechanism-based rational design of cisplatin analogues
The success of cisplatin as an anticancer drug is attributed to the ability of the platinum compound to damage DNA and subsequently induce apoptosis. Details of the cellular processing of cisplatin-damaged DNA can provide invaluable insight into the rational design of cisplatin analogues or …
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Sustained-release implants for intraperitoneal cisplatin delivery
… materials for continuous low-dose delivery of cisplatin directly into the abdomen, also known as intraperitoneal (IP) chemotherapy. IP chemotherapy can help treat peritoneal metastasis in many advanced gynecologic and gastrointestinal cancers and has shown particular promise in treating …
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Investigation into ubiquitin signalling in response to cisplatin
Cisplatin is an anti-cancer drug that acts by introducing toxic DNA interstrand crosslinks into proliferating cells, causing both cytostatic and cytotoxic effects. Although various models of the interstrand crosslink (ICL) response have been proposed, none of them are complete and much still …
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Understanding and improving the anticancer activity of cisplatin
… of action of cis-diamminedichloroplatinum(II) (cisplatin), one of the most effective anticancer drugs. Since its serendipitous discovery in 1970, cisplatin has served to help cure testicular cancer and treat a variety of human malignancies. It is widely accepted that DNA is the cellular target …
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TARGETING COCHLEAR INFLAMMATION FOR THE TREATMENT OF CISPLATIN OTOTOXICITY
… to damage to the ear (-oto) due to xenobiotics. Cisplatin is the most widely used antineoplastic agent in the treatment of various solid tumors. Cisplatin toxicity can lead to severe effects on the kidneys, nervous system and auditory system which significantly reduce the quality of life of …
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Enhancing Cisplatin Delivery and Anti-tumor Efficacy Using Hyperthermia
… of numerous chemotherapeutic agents, including cisplatin, resulting in increased cytotoxicity. In addition to these biological responses, hyperthermia can be used as a drug-release trigger for temperature-sensitive nanoparticles, resulting in an improved and more targeted drug delivery system. …
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The responses of cellular proteins to cisplatin-damaged DNA
The anticancer drug cisplatin is a small inorganic molecule that forms several types of covalent adducts on DNA. There is evidence that at least some of the consequences of this genetic damage are mediated by proteins that bind to the cisplatin-DNA cross-links or influence cellular pathways in …
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Astrocytes Rescue Neuronal Health After Cisplatin Treatment Through Mitochondrial Transfer.
… <p>Astrocytes rescue neuronal health after cisplatin treatment through mitochondrial transfer.</p> <p>Author: Krystal English</p> <p>Advisory Professor: Dr. Cobi J. Heijnen, Ph.D.</p> <p>Chemotherapy-induced cognitive impairments are associated with neuronal mitochondrial dysfunction. …
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HPLC analysis to assess efficacy of cisplatin, nedaplatin, and oxaliplatin
… most widely used agents against cancerous cells. Cisplatin’s chemotherapeutic efficacy is limited by the increase of tumor resistivity and unwanted side effects. Cisplatin’s cytotoxicity is linked to its ability of forming 1,2-intrastrand adducts with adjacent guanine (G) bases. An analytical …
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Cisplatin cytotoxicity associated with tetracycline resistance determinants in Escherichia coli
… destruction by the DNA-damaging anti-cancer drug cisplatin. Tetracycline-resistant bacteria grown in tetracycline and subsequently treated with cisplatin in the presence of tetracycline were killed about 10⁵-fold more effectively than wild-type bacteria and tetracycline-resistant bacteria not …
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Effects of Cisplatin Analog Size on the Reaction with DNA Bases
… leading cause of death in the United States. Cisplatin is one of the well-known anti-cancer agents used to treat testicular and ovarian cancers. It mainly binds to the DNA bases, which leads to cell death. The cytotoxic activity of the cisplatin analogs is due to the interaction of platinum …
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Synthesis, Characterization, And Rna Reactivity Of Amino-Acid-Linked Cisplatin Analogues
… diversity. The well-known anticancer drug cisplatin was previously applied as a chemical probe of rRNA structure to determine solvent accessible purines (guanosine) in vivo and in vitro. Cisplatin accumulates faster on RNA than DNA, with less chance of repair. As such, designing new …
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Contribution of Organic Cation Transporter 2 (OCT2) to Cisplatin-Induced Nephrotoxicity
<p>Cisplatin is the most widely used anticancer agent; however, the cellular pharmacokinetics are poorly understood. Cisplatin is predominantly eliminated through the urine via active secretion and is associated with nephrotoxicity. Currently, prehydration therapy is employed to prevent toxic renal …
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FLUOXETINE AS A NOVEL TREATMENT TO ATTENUATE CISPLATIN-INDUCED COGNITIVE IMPAIRMENT
<p>Cisplatin, a chemotherapeutic agent, initiates cell death through various methods that include mtDNA damage during cell replication and produces damaging pro-inflammatory cytokines. This can result in long-term chemotherapy-related cognitive impairment (CRCI). Fluoxetine (FLX) is a selective …
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The role of TREX1 and TREX2 in cellular responses to cisplatin
Cisplatin is a platinum-based chemotherapeutic agent that is used in the treatment of multiple cancer types including hepatocellular carcinoma, osteosarcoma and ovarian cancer, yet the development of resistance remains a significant barrier to therapy success. Resistance to cisplatin is commonly …
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Exploring the effects of maternal immune activation on cisplatin-induced toxicities.
… we wanted to determine if MIA would exacerbate cisplatin-induced fatigue and affective problems in adulthood. On gestational. Day 12.5, dams were injected with 20 mg/kg Poly(I:C) or vehicle. At six weeks old, offspring were single housed with running wheels and 14 days later were injected with …
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Crystal structure of the anticancer drug cisplatin bound to duplex DNA
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1996.
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Multi-cycle cisplatin treatment alters spermatogonial functional stem cell behavior and niche
… clinical cis-diamminedichloroplatinum (II) (cisplatin) dosing regimen consists of repeated cycles of five to seven daily low dose treatments followed by a one to two week recovery period. While effective, this dosing structure results in a prolonged, and sometimes permanent, infertility in …
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