Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Cis-regulatory element"”.
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Characterisation of a conserved motif found within the Dlx cis-regulatory element URE2 and its effect on mouse URE2-lacZ activity in transgenic mice
… as well as their migration to the cortex. The cis-regulatory element URE2 (enhancer) is located upstream of Dlx1 and is thought to regulate the transcription of Dlx1 and/or Dlx2. The objective of this study was to examine a short conserved sequence within the URE2 element, corresponding to …
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Sex-specific expression of CYP2C2 in transgenic mice and phenobarbital regulation of CYP2B by in situ injection
… contains the basal transcriptional regulation elements for tissue-specific and developmental expression. This transgene may include the cis-regulatory element for sexual dimorphic expression or a nearby enhancer in the mouse genome may be responsible (position effect).
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Tracing the evolution of lineage-specific transcription factor binding sites in a birth-death framework
Changes in cis-regulatory element composition that result in novel patterns of gene expression are thought to be a major contributor to the evolution of lineage-specific traits. Although transcription factor binding events show substantial variation across species, most computational approaches to …
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Appendage development and early Distal-less regulation in arthropods: A study of the chelicerate Tetranychus urticae (Acarida)
… is to compare signalling mediated by early Dll regulatory genes activity along antero-posterior and dorso-ventral embryonic axes during limb specification in Drosophila, with the activity of their orthologs in the widely disparate chelicerate, the spider mite Tetranychus urticae – interpreting …
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Genome-wide prediction of developmental enhancers and analysis of evolutionary plasticity in Drosophila
… the development of the Drosophila embryo is a precise and coordinated control of gene expression, both spatially and temporally. This process of complex transcription regulation is thought to be achieved by the combinatorial action of multiple transcription factors binding to modular units of …
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Regulation of segment polarity genes in the head region of different arthropods
… based on anterior head segment-specific cross-regulatory interactions among segment polarity genes (Gallitano-Mendel and Finkelstein, 1997). So far it remains unclear how the establishment of the procephalic segment polarity gene expression is controlled, although a functional input from the …
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The study of transcriptional regulation of necrotrophic effector genes ToxA and Tox3 in the wheat pathogen Parastagonospora nodorum
… deletion analysis, I was unable to identify a cis-regulatory element other than TATA box on the ToxA promoter. DNase I footprinting and yeast one-hybrid assay also did not identify protein candidates interacting with the ToxA promoter. Interestingly, the ToxA promoter showed ability to induce …
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The study of transcriptional regulation of necrotrophic effector genes ToxA and Tox3 in the wheat pathogen Parastagonospora nodorum
… deletion analysis, I was unable to identify a cis-regulatory element other than TATA box on the ToxA promoter. DNase I footprinting and yeast one-hybrid assay also did not identify protein candidates interacting with the ToxA promoter. Interestingly, the ToxA promoter showed ability to induce …
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Disease susceptibility and phenotypic adaptations as seen through the lens of comparative functional genomics
… the genome, which can affect gene function and regulatory elements, ultimately influencing the phenotype. This thesis investigates how evolutionary changes in genomic background and selection events at the expression and regulation levels impact cancer susceptibility and phenotypic adaptation. …
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Genetic Mechanisms of Transcriptional Regulation in Childhood Acute Lymphoblastic Leukemia
… variants contribute to the transcriptional regulatory circuitries of ALL is still poorly understood. We tested these hypotheses: 1) A low ARID5B expression will increase the relapse risk of ALL, 2) Genetic variants of ARID5B will affect its expression and thus influence susceptibility to …